Entity Details

Primary name SERPINE1
Entity type gene
Source Source Link

Details

PrimaryID5054
RefseqGeneNG_013213
SymbolSERPINE1
Nameserpin family E member 1
Chromosome7
Location7q22.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-11-03
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsPAI1_HUMAN

GO terms

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GOName
GO:0001525 angiogenesis
GO:0002020 protease binding
GO:0002576 platelet degranulation
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0007623 circadian rhythm
GO:0010469 regulation of signaling receptor activity
GO:0010757 negative regulation of plasminogen activation
GO:0010951 negative regulation of endopeptidase activity
GO:0014912 negative regulation of smooth muscle cell migration
GO:0030194 positive regulation of blood coagulation
GO:0030195 negative regulation of blood coagulation
GO:0030198 extracellular matrix organization
GO:0030336 negative regulation of cell migration
GO:0031093 platelet alpha granule lumen
GO:0032757 positive regulation of interleukin-8 production
GO:0033629 negative regulation of cell adhesion mediated by integrin
GO:0035491 positive regulation of leukotriene production involved in inflammatory response
GO:0042730 fibrinolysis
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0050729 positive regulation of inflammatory response
GO:0050829 defense response to Gram-negative bacterium
GO:0051918 negative regulation of fibrinolysis
GO:0061044 negative regulation of vascular wound healing
GO:0061045 negative regulation of wound healing
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0071222 cellular response to lipopolysaccharide
GO:0090026 positive regulation of monocyte chemotaxis
GO:0090399 replicative senescence
GO:0097187 dentinogenesis
GO:1901331 positive regulation of odontoblast differentiation
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000098 negative regulation of smooth muscle cell-matrix adhesion
GO:2000352 negative regulation of endothelial cell apoptotic process

Diseases

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Interactions

37 interactions

InteractorPartnerSourcesPublicationsLink
SERPINE1UBQLN4BioGRID, HPRD, IntAct16713569 details
SERPINE1ORM1BioGRID, HPRD, IntAct11418606 16272158 details
SERPINE1VTNBioGRID, HPRD, IntAct11113116 11796824 12808446 8830783 9065424 details
SERPINE1PLAUBioGRID, HPRD, MINT2161846 22449964 2544876 3090045 9184208 details
SERPINE1PLATBioGRID, HPRD, MINT2110366 22449964 3090045 8607113 details
SERPINE1SGTABioGRID, IntAct25416956 32296183 details
SERPINE1SGTBBioGRID, IntAct25416956 32296183 details
SERPINE1UBQLN1BioGRID, IntAct25416956 details
SERPINE1UBQLN2BioGRID, IntAct32296183 details
SERPINE1TLX3BioGRID, IntAct32296183 details
SERPINE1HSD17B11BioGRID, IntAct32296183 details
SERPINE1PITX1BioGRID, IntAct32296183 details
SERPINE1TMEM237BioGRID, IntAct32296183 details
SERPINE1F2BioGRID, HPRD10543954 12709053 details
SERPINE1PLGBioGRID, HPRD11113116 details
SERPINE1LMNABioGRID24623722 details
SERPINE1ACTN4HPRD15493875 details
SERPINE1KRT18HPRD15493875 details
SERPINE1LRP1BioGRID, HPRD15001579 details
SERPINE1SERPINE1BioGRID, HPRD10731421 details
SERPINE1IGFBP5BioGRID, HPRD9202242 details
SERPINE1PSMA3BioGRID21135093 details
SERPINE1PSMB1BioGRID21135093 details
SERPINE1USF2BioGRID23991099 details
SERPINE1MMP3HPRD10967118 details
SERPINE1LRP2HPRD8344937 details
SERPINE1LRP1BHPRD11384978 details
SERPINE1ELANEHPRD7521069 details
SERPINE1KLK2HPRD10209959 details
SERPINE1PTBP3MINT22575643 details
SERPINE1GANABBioGRID, IntAct30833792 details
SERPINE1ANP32ABioGRID, IntAct30833792 details
SERPINE1ERP29BioGRID, IntAct30833792 details
SERPINE1HSP90B1BioGRID, IntAct30833792 details
SERPINE1CFTRIntAct29924966 details
SERPINE1NOS2BioGRID23438482 details
SERPINE1ASS1BioGRID31536960 details