Entity Details

Primary name PDGFB
Entity type gene
Source Source Link

Details

PrimaryID5155
RefseqGeneNG_012111
SymbolPDGFB
Nameplatelet derived growth factor subunit B
Chromosome22
Location22q13.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1988-12-05
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsPDGFB_HUMAN

GO terms

Show/Hide Table
GOName
GO:0000139 Golgi membrane
GO:0000165 MAPK cascade
GO:0001892 embryonic placenta development
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002548 monocyte chemotaxis
GO:0002576 platelet degranulation
GO:0003104 positive regulation of glomerular filtration
GO:0005161 platelet-derived growth factor receptor binding
GO:0005518 collagen binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0006468 protein phosphorylation
GO:0007507 heart development
GO:0008083 growth factor activity
GO:0008284 positive regulation of cell population proliferation
GO:0009611 response to wounding
GO:0009986 cell surface
GO:0010512 negative regulation of phosphatidylinositol biosynthetic process
GO:0010544 negative regulation of platelet activation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010811 positive regulation of cell-substrate adhesion
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016176 superoxide-generating NADPH oxidase activator activity
GO:0016323 basolateral plasma membrane
GO:0018105 peptidyl-serine phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0031093 platelet alpha granule lumen
GO:0031954 positive regulation of protein autophosphorylation
GO:0032091 negative regulation of protein binding
GO:0032147 activation of protein kinase activity
GO:0032148 activation of protein kinase B activity
GO:0035655 interleukin-18-mediated signaling pathway
GO:0035793 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0038001 paracrine signaling
GO:0042056 chemoattractant activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045840 positive regulation of mitotic nuclear division
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046982 protein heterodimerization activity
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048146 positive regulation of fibroblast proliferation
GO:0048407 platelet-derived growth factor binding
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050921 positive regulation of chemotaxis
GO:0051781 positive regulation of cell division
GO:0051897 positive regulation of protein kinase B signaling
GO:0060326 cell chemotaxis
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0062023 collagen-containing extracellular matrix
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070528 protein kinase C signaling
GO:0070851 growth factor receptor binding
GO:0071363 cellular response to growth factor stimulus
GO:0071506 cellular response to mycophenolic acid
GO:0072126 positive regulation of glomerular mesangial cell proliferation
GO:0072255 metanephric glomerular mesangial cell development
GO:0072593 reactive oxygen species metabolic process
GO:0090280 positive regulation of calcium ion import
GO:1900127 positive regulation of hyaluronan biosynthetic process
GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1904754 positive regulation of vascular associated smooth muscle cell migration
GO:1905064 negative regulation of vascular associated smooth muscle cell differentiation
GO:1905176 positive regulation of vascular associated smooth muscle cell dedifferentiation
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000573 positive regulation of DNA biosynthetic process
GO:2000591 positive regulation of metanephric mesenchymal cell migration

Diseases

Show/Hide Table

Interactions

86 interactions

InteractorPartnerSourcesPublicationsLink
PDGFBPDGFRBBioGRID, DIP, HPRD, IntAct10806482 11297552 11903042 17981115 18593464 20534510 20577048 7679113 details
PDGFBMDFIBioGRID, IntAct19060904 details
PDGFBPDGFBBioGRID, DIP, HPRD, IntAct1396586 23139410 7679113 details
PDGFBPDGFAIntAct7679113 details
PDGFBPDGFRABioGRID, DIP, HPRD, IntAct10806482 11297552 15767546 2544881 7679113 9677323 details
PDGFBBCCIPBioGRID, IntAct32296183 details
PDGFBLRP1BioGRID, HPRD11854294 details
PDGFBSPARCBioGRID1311092 details
PDGFBTHBS1BioGRID, HPRD9334164 details
PDGFBHSPG2BioGRID, HPRD9692901 details
PDGFBCOL1A1BioGRID, HPRD10446987 8900172 details
PDGFBCOL1A2BioGRID8900172 details
PDGFBCOL2A1BioGRID8900172 details
PDGFBCOL3A1BioGRID8900172 details
PDGFBCOL4A1BioGRID8900172 details
PDGFBCOL5A1BioGRID8900172 details
PDGFBCOL6A1BioGRID8900172 details
PDGFBLYVE1BioGRID7829517 details
PDGFBFBXO7BioGRID27503909 details
PDGFBPIK3R1BioGRID1372091 details
PDGFBPDAP1BioGRID, HPRD8780057 details
PDGFBADIPOQBioGRID12070119 details
PDGFBNRP1BioGRID16847823 20577048 details
PDGFBHRASHPRD10485711 details
PDGFBART1HPRD11498506 details
PDGFBA2MHPRD10681572 details
PDGFBHNRNPCHPRD10409733 details
PDGFBVEGFAbhf-ucl17470632 details
PDGFBMYBBP1ABioGRID, IntAct28514442 details
PDGFBADGRV1BioGRID, IntAct28514442 details
PDGFBDHX30BioGRID, IntAct28514442 details
PDGFBMRPL51BioGRID, IntAct28514442 details
PDGFBNOC2LBioGRID, IntAct28514442 details
PDGFBMRPS18CBioGRID, IntAct28514442 details
PDGFBMRPS33BioGRID, IntAct28514442 details
PDGFBZC3H4BioGRID, IntAct28514442 details
PDGFBRPL26L1BioGRID, IntAct28514442 details
PDGFBMRPL27BioGRID, IntAct28514442 details
PDGFBNOP53BioGRID, IntAct28514442 details
PDGFBTEX10BioGRID, IntAct28514442 details
PDGFBRBM28BioGRID, IntAct28514442 details
PDGFBUTP3BioGRID, IntAct28514442 details
PDGFBPPANIntAct28514442 details
PDGFBPPAN-P2RY11BioGRID, IntAct28514442 details
PDGFBMRPL47BioGRID, IntAct28514442 details
PDGFBRPF2BioGRID, IntAct28514442 details
PDGFBMRPL13BioGRID, IntAct28514442 details
PDGFBNOC4LBioGRID, IntAct28514442 details
PDGFBUTP23BioGRID, IntAct28514442 details
PDGFBBUD13BioGRID, IntAct28514442 details
PDGFBEBNA1BP2BioGRID, IntAct28514442 details
PDGFBPTCD3BioGRID, IntAct28514442 details
PDGFBMRPS24BioGRID, IntAct28514442 details
PDGFBMALSU1BioGRID, IntAct28514442 details
PDGFBRPL36ALBioGRID, IntAct28514442 details
PDGFBMRPS31BioGRID, IntAct28514442 details
PDGFBNOC3LBioGRID, IntAct28514442 details
PDGFBFAT3BioGRID, IntAct28514442 details
PDGFBBRIX1BioGRID, IntAct28514442 details
PDGFBDDX54BioGRID, IntAct28514442 details
PDGFBMRPL30BioGRID, IntAct28514442 details
PDGFBKRI1BioGRID, IntAct28514442 details
PDGFBSRRM1BioGRID, IntAct28514442 details
PDGFBNKAPD1BioGRID, IntAct28514442 details
PDGFBFAT4BioGRID, IntAct28514442 details
PDGFBFREM2BioGRID, IntAct28514442 details
PDGFBRRP12BioGRID, IntAct28514442 details
PDGFBGLYR1BioGRID, IntAct28514442 details
PDGFBPUM3BioGRID, IntAct28514442 details
PDGFBBMS1BioGRID, IntAct28514442 details
PDGFBFAT1BioGRID, IntAct28514442 details
PDGFBGNL2BioGRID, IntAct28514442 details
PDGFBC1QBPBioGRID, IntAct28514442 details
PDGFBCEBPZBioGRID, IntAct28514442 details
PDGFBMDM2BioGRID, IntAct28514442 details
PDGFBMRPS9BioGRID, IntAct28514442 details
PDGFBMRPS5BioGRID, IntAct28514442 details
PDGFBMRPS35BioGRID, IntAct28514442 details
PDGFBRPS15BioGRID, IntAct28514442 details
PDGFBRPL15BioGRID, IntAct28514442 details
PDGFBRBM34BioGRID, IntAct28514442 details
PDGFBRPS3BioGRID, IntAct28514442 details
PDGFBNSA2BioGRID, IntAct28514442 details
PDGFBMYCBP2BioGRID, IntAct28514442 details
PDGFBDKC1BioGRID, IntAct28514442 details
PDGFBSOCS1BioGRID29991678 details