Entity Details

Primary name OCLN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16625
EntryNameOCLN_HUMAN
FullNameOccludin
TaxID9606
Evidenceevidence at protein level
Length522
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesOCLN

GO terms

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GOName
GO:0001933 negative regulation of protein phosphorylation
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005923 bicellular tight junction
GO:0010592 positive regulation of lamellipodium assembly
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010827 regulation of glucose transmembrane transport
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0016327 apicolateral plasma membrane
GO:0016328 lateral plasma membrane
GO:0019904 protein domain specific binding
GO:0030054 cell junction
GO:0030139 endocytic vesicle
GO:0031116 positive regulation of microtubule polymerization
GO:0031252 cell leading edge
GO:0031410 cytoplasmic vesicle
GO:0032991 protein-containing complex
GO:0035633 maintenance of blood-brain barrier
GO:0045216 cell-cell junction organization
GO:0046326 positive regulation of glucose import
GO:0065003 protein-containing complex assembly
GO:0070160 tight junction
GO:0070673 response to interleukin-18
GO:0070830 bicellular tight junction assembly
GO:0071356 cellular response to tumor necrosis factor
GO:0090303 positive regulation of wound healing
GO:1902463 protein localization to cell leading edge
GO:1905605 positive regulation of blood-brain barrier permeability
GO:2000810 regulation of bicellular tight junction assembly

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR002958 OccludinFamilyFamily
IPR008253 Marvel domainDomainDomain
IPR010844 Occludin homology domainDomainDomain
IPR031176 ELL/occludin familyFamilyFamily
IPR036259 MFS transporter superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
251290 OMIMPseudo-TORCH syndrome 1 (PTORCH1)An autosomal recessive neurologic disorder with characteristic clinical and neuroradiologic features that mimic intrauterine TORCH infection in the absence of evidence of infection. Affected individuals have congenital microcephaly, intracranial calcifications, and severe developmental delay. The disease is caused by variants affecting the gene represented in this entry.

Interactions

37 interactions

InteractorPartnerSourcesPublicationsLink
OCLN_HUMANKC1E_HUMANBioGRID, HPRD, IntAct, MINT16616143 25241761 28514442 details
OCLN_HUMANULK1_HUMANBioGRID, MINT16616143 details
OCLN_HUMANSNW1_HUMANBioGRID, MINT16616143 details
OCLN_HUMANKC1A_HUMANBioGRID, HPRD, MINT16616143 details
OCLN_HUMANZO1_HUMANBioGRID, HPRD, Molecular Connections10575001 10601346 11700038 12169098 18662404 19017651 23758859 26090670 33100129 34079125 7798316 9792688 details
OCLN_HUMANSYNE4_HUMANBioGRID, IntAct25416956 26186194 28514442 details
OCLN_HUMANCLC7A_HUMANBioGRID, IntAct25416956 details
OCLN_HUMANGPX8_HUMANBioGRID, IntAct32296183 details
OCLN_HUMANCATS_HUMANDIP25086747 details
OCLN_HUMANKPCL_HUMANDIP19114660 details
OCLN_HUMANDYN2_HUMANIntAct32814053 details
OCLN_HUMANNDUV2_HUMANIntAct32814053 details
OCLN_HUMANZO2_HUMANBioGRID, HPRD10026224 10575001 14512431 23758859 34079125 details
OCLN_HUMANITCH_HUMANBioGRID, HPRD11782481 19478092 33100129 34079125 details
OCLN_HUMANTNAP3_HUMANBioGRID22031828 details
OCLN_HUMANFATE1_HUMANBioGRID21516116 details
OCLN_HUMANPTN2_HUMANBioGRID26090670 details
OCLN_HUMANCSK21_HUMANBioGRID23758859 details
OCLN_HUMANOCLN_HUMANBioGRID, HPRD10026224 23758859 details
OCLN_HUMANOGT1_HUMANBioGRID32994395 details
OCLN_HUMANPLS1_HUMANMINT21806988 details
OCLN_HUMANNED4L_HUMANBioGRID, IntAct20504882 28514442 details
OCLN_HUMANRAB8B_HUMANBioGRID12639940 details
OCLN_HUMANYES_HUMANBioGRID, HPRD11950934 34079125 details
OCLN_HUMANCXB1_HUMANBioGRID, HPRD10581193 details
OCLN_HUMANEPN1_HUMANBioGRID19478092 details
OCLN_HUMANEPS15_HUMANBioGRID19478092 details
OCLN_HUMANHGS_HUMANBioGRID19478092 details
OCLN_HUMANTGFR1_HUMANBioGRID, HPRD15761153 details
OCLN_HUMANTGFR2_HUMANBioGRID15761153 details
OCLN_HUMANKPCA_HUMANHPRD11502742 details
OCLN_HUMANKPCB_HUMANHPRD11502742 details
OCLN_HUMANKPCG_HUMANHPRD11502742 details
OCLN_HUMANCSK2B_HUMANHPRD12804768 details
OCLN_HUMANSMAD4_HUMANHPRD15761153 details
OCLN_HUMANSMUF1_HUMANHPRD15761153 details
OCLN_HUMANACTS_HUMANHPRD10575001 9792688 details