Entity Details

Primary name MAP2K1
Entity type gene
Source Source Link

Details

PrimaryID5604
RefseqGeneNG_008305
SymbolMAP2K1
Namemitogen-activated protein kinase kinase 1
Chromosome15
Location15q22.31
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-09-14
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsMP2K1_HUMAN

GO terms

Show/Hide Table
GOName
GO:0000165 MAPK cascade
GO:0000186 obsolete activation of MAPKK activity
GO:0000187 obsolete activation of MAPK activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005078 MAP-kinase scaffold activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006468 protein phosphorylation
GO:0006935 chemotaxis
GO:0007165 signal transduction
GO:0007507 heart development
GO:0008022 protein C-terminus binding
GO:0008285 negative regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0018107 peptidyl-threonine phosphorylation
GO:0021697 cerebellar cortex formation
GO:0030182 neuron differentiation
GO:0030216 keratinocyte differentiation
GO:0030878 thyroid gland development
GO:0032872 regulation of stress-activated MAPK cascade
GO:0043539 protein serine/threonine kinase activator activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0047485 protein N-terminus binding
GO:0048538 thymus development
GO:0048679 regulation of axon regeneration
GO:0048870 cell motility
GO:0050772 positive regulation of axonogenesis
GO:0060020 Bergmann glial cell differentiation
GO:0060324 face development
GO:0060440 trachea formation
GO:0060502 epithelial cell proliferation involved in lung morphogenesis
GO:0060674 placenta blood vessel development
GO:0060711 labyrinthine layer development
GO:0070371 ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090170 regulation of Golgi inheritance
GO:0090398 cellular senescence
GO:0097110 scaffold protein binding
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:2000641 regulation of early endosome to late endosome transport

Diseases

Show/Hide Table

Interactions

217 interactions

InteractorPartnerSourcesPublicationsLink
MAP2K1MAPK1BioGRID, HPRD, MINT10757792 11134045 11266467 11279118 11352917 11741894 11823456 12594221 12697810 12788955 17255949 19058874 21336309 21675959 23241949 24623782 27884160 8157000 details
MAP2K1BRAFBioGRID, DIP, HPRD, IntAct16810323 16888650 17979178 18332145 19371126 20212043 23934108 24746704 25155755 25437913 25600339 26496610 27034005 27684187 28514442 31015455 31980649 7731720 8157000 8394352 8621729 9733801 details
MAP2K1RAF1BioGRID, DIP, HPRD, IntAct, MINT10757792 10958680 11604401 15485920 15866172 16093354 17724343 17979178 18556463 19058874 19197339 20212043 21336309 23934108 24746704 25155755 26496610 27703006 31980649 7527398 7731720 8157000 8394352 8621729 9311917 9733801 details
MAP2K1ARAFBioGRID, HPRD, IntAct17979178 24114843 24746704 26496610 31980649 7731720 8157000 8394352 8621729 details
MAP2K1PEBP4BioGRID, HPRD, MINT15302887 19197339 details
MAP2K1MAPK3BioGRID, HPRD, MINT10748187 19058874 19197339 8226933 8626767 9006895 9733512 details
MAP2K1WNK1BioGRID, IntAct20936779 details
MAP2K1APCBioGRID, MINT24412244 details
MAP2K1AURKABioGRID, MINT24412244 details
MAP2K1BAXBioGRID, MINT24412244 details
MAP2K1BMPR1ABioGRID, MINT24412244 details
MAP2K1BUB1BioGRID, MINT24412244 details
MAP2K1CDH1BioGRID, MINT24412244 details
MAP2K1CDKN2ABioGRID, MINT24412244 details
MAP2K1CTNNA1BioGRID, MINT24412244 details
MAP2K1ERBB2BioGRID, MINT24412244 details
MAP2K1FBXW7BioGRID, MINT24412244 details
MAP2K1MLH3BioGRID, MINT24412244 details
MAP2K1MSH6BioGRID, MINT24412244 details
MAP2K1ODC1BioGRID, MINT24412244 details
MAP2K1PDGFRLBioGRID, MINT24412244 details
MAP2K1PIK3CABioGRID, MINT24412244 details
MAP2K1PTPRJBioGRID, MINT24412244 details
MAP2K1SMAD2BioGRID, MINT24412244 details
MAP2K1SRCBioGRID, MINT24412244 details
MAP2K1STK11BioGRID, MINT24412244 details
MAP2K1TGFBR2BioGRID, MINT24412244 details
MAP2K1TLR2BioGRID, MINT24412244 details
MAP2K1MAP3K8BioGRID, IntAct12832462 16291755 8631303 details
MAP2K1BANPBioGRID, IntAct25416956 32296183 details
MAP2K1TCP11BioGRID, IntAct32296183 details
MAP2K1PLEKHF2BioGRID, IntAct32296183 details
MAP2K1PIN1UniProt20179161 details
MAP2K1PEBP1BioGRID, HPRD10757792 details
MAP2K1MAPK8IP3BioGRID, HPRD10523642 11044439 details
MAP2K1LAMTOR3BioGRID, HPRD11266467 9733512 details
MAP2K1GRB10BioGRID, HPRD9553107 details
MAP2K1MAP2K1BioGRID, HPRD12697810 17979178 31980649 8226933 9733512 details
MAP2K1MAP3K4BioGRID, HPRD9841871 details
MAP2K1MAPK8BioGRID16533805 details
MAP2K1HNRNPDBioGRID15231747 details
MAP2K1PPARGBioGRID17101779 21690289 details
MAP2K1UBE2IBioGRID21336309 details
MAP2K1KAT7BioGRID23319590 details
MAP2K1BMI1BioGRID27878292 details
MAP2K1MBPBioGRID8617731 details
MAP2K1ITCHBioGRID31015455 details
MAP2K1TRIB1HPRD, IntAct15299019 details
MAP2K1TRIB3IntAct15299019 details
MAP2K1HLA-BIntAct17353931 details
MAP2K1CFLARMINT17110930 details
MAP2K1MAP3K1BioGRID, MINT10969079 14500727 17110930 details
MAP2K1KSR1BioGRID, HPRD, IntAct11741534 11940661 15090600 15520859 17979178 18332145 26496610 27086506 31980649 details
MAP2K1YWHABBioGRID, IntAct10409742 17979178 24255178 31980649 details
MAP2K1BIRC6HPRD, IntAct18329369 details
MAP2K1VRK2IntAct20679487 22752157 details
MAP2K1CALRIntAct22752157 details
MAP2K1YAP1BioGRID, MINT24211253 27684187 details
MAP2K1BTRCBioGRID, MINT24211253 details
MAP2K1MYCBioGRID, HPRD, IntAct26496610 7957875 details
MAP2K1KSR2BioGRID, HPRD, IntAct12975377 27086506 details
MAP2K1MAP2K2BioGRID, IntAct10409742 28514442 details
MAP2K1LAMTOR2BioGRID11266467 details
MAP2K1VAV1BioGRID8900182 details
MAP2K1HRASBioGRID, HPRD7969158 details
MAP2K1ARRB2BioGRID11226259 details
MAP2K1BRAPBioGRID18332145 details
MAP2K1WDR83BioGRID15118098 details
MAP2K1LSP1BioGRID15090600 details
MAP2K1IQGAP1BioGRID24639526 27684187 details
MAP2K1NFE2L2BioGRID24704364 details
MAP2K1ZC3H7ABioGRID29395067 details
MAP2K1RPS6KA2HPRD8939914 details
MAP2K1TRAF3HPRD8626767 details
MAP2K1CASP9HPRD12792650 details
MAP2K1PAK1HPRD9351825 details
MAP2K1RPS6KA4HPRD10806207 details
MAP2K1CPNE1HPRD12522145 details
MAP2K1CPNE4HPRD12522145 details
MAP2K1PARVAHPRD15353548 details
MAP2K1PLK3HPRD15021912 details
MAP2K1EGFRHPRD12556561 details
MAP2K1PRKCZHPRD11535599 details
MAP2K1PRKCIHPRD10848576 details
MAP2K1ELK1HPRD10716983 10997882 details
MAP2K1MAPK14HPRD12697810 details
MAP2K1TRAF6HPRD16313339 details
MAP2K1EP300HPRD11278389 details
MAP2K1CDK5HPRD11684694 details
MAP2K1YWHAZBioGRID, IntAct17979178 27684187 31980649 details
MAP2K1HSPA1ABioGRID, IntAct17979178 details
MAP2K1HSPA1BIntAct17979178 details
MAP2K1HSPA8BioGRID, IntAct17979178 27684187 details
MAP2K1YWHAEBioGRID, IntAct17979178 31980649 details
MAP2K1PKMIntAct24606918 details
MAP2K1THOC2BioGRID, IntAct26496610 details
MAP2K1SKA3BioGRID, IntAct26496610 details
MAP2K1DCP1ABioGRID, IntAct26496610 details
MAP2K1ZNF277BioGRID, IntAct26496610 details
MAP2K1RBM33BioGRID, IntAct26496610 details
MAP2K1TCTN1BioGRID, IntAct26638075 details
MAP2K1POC5BioGRID, IntAct26638075 details
MAP2K1HSCBBioGRID, IntAct28380382 details
MAP2K1NUFIP1BioGRID, IntAct26186194 28514442 details
MAP2K1FGBBioGRID, IntAct28514442 details
MAP2K1RNASE9BioGRID, IntAct28514442 details
MAP2K1YWHAGBioGRID, IntAct28514442 31980649 details
MAP2K1YWHAHBioGRID, IntAct28514442 31980649 details
MAP2K1BLVRADIP18463290 details
MAP2K1PSMD10BioGRID, IntAct24338975 details
MAP2K1LRRK2IntAct31046837 details
MAP2K1HNRNPDLBioGRID, IntAct31980649 details
MAP2K1RRP9BioGRID, IntAct31980649 details
MAP2K1NPM3BioGRID, IntAct31980649 details
MAP2K1NDUFA10BioGRID, IntAct31980649 details
MAP2K1KRASBioGRID, IntAct27684187 31980649 details
MAP2K1H1-0BioGRID, IntAct31980649 details
MAP2K1TPRBioGRID, IntAct31980649 details
MAP2K1UQCRBBioGRID, IntAct31980649 details
MAP2K1HMGA1BioGRID, IntAct31980649 details
MAP2K1VARS1BioGRID, IntAct31980649 details
MAP2K1YWHAQBioGRID, IntAct31980649 details
MAP2K1MCM4BioGRID, IntAct31980649 details
MAP2K1NOP2BioGRID, IntAct31980649 details
MAP2K1RPL29BioGRID, IntAct31980649 details
MAP2K1UQCRFS1BioGRID, IntAct31980649 details
MAP2K1RBM25BioGRID, IntAct31980649 details
MAP2K1CBX1BioGRID, IntAct31980649 details
MAP2K1AKAP12BioGRID, IntAct31980649 details
MAP2K1TARDBPBioGRID, IntAct31980649 details
MAP2K1CBX3BioGRID, IntAct31980649 details
MAP2K1SRSF5BioGRID, IntAct31980649 details
MAP2K1FKBP5BioGRID, IntAct31980649 details
MAP2K1KRR1BioGRID, IntAct31980649 details
MAP2K1CDC37BioGRID, IntAct31980649 details
MAP2K1TOR1AIP1BioGRID, IntAct31980649 details
MAP2K1GNL3BioGRID, IntAct31980649 details
MAP2K1NAT10BioGRID, IntAct31980649 details
MAP2K1TOMM22BioGRID, IntAct31980649 details
MAP2K1ATAD3ABioGRID, IntAct31980649 details
MAP2K1DDX18BioGRID, IntAct31980649 details
MAP2K1RALYBioGRID, IntAct31980649 details
MAP2K1NOP58BioGRID, IntAct31980649 details
MAP2K1NOC2LBioGRID, IntAct31980649 details
MAP2K1RAC1BioGRID, IntAct31980649 details
MAP2K1SLC16A3BioGRID, IntAct31980649 details
MAP2K1DNAJA2BioGRID, IntAct31980649 details
MAP2K1PLPBPBioGRID, IntAct31980649 details
MAP2K1HSPB1BioGRID, IntAct27684187 31980649 details
MAP2K1CD9BioGRID, IntAct31980649 details
MAP2K1FBLBioGRID, IntAct31980649 details
MAP2K1ITGA3BioGRID, IntAct31980649 details
MAP2K1CADBioGRID, IntAct31980649 details
MAP2K1NT5C2BioGRID, IntAct31980649 details
MAP2K1RAB5CBioGRID, IntAct31980649 details
MAP2K1SLC7A5BioGRID, IntAct31980649 details
MAP2K1FAT1BioGRID, IntAct31980649 details
MAP2K1STK38BioGRID, IntAct31980649 details
MAP2K1RCN1BioGRID, IntAct31980649 details
MAP2K1TCF25BioGRID, IntAct31980649 details
MAP2K1CAMSAP3BioGRID, IntAct31980649 details
MAP2K1SLAIN2BioGRID, IntAct31980649 details
MAP2K1DPP7BioGRID, IntAct31980649 details
MAP2K1ZDHHC5UniProt31402609 details
MAP2K1VCPBioGRID23383273 27684187 details
MAP2K1DGUOKBioGRID26186194 details
MAP2K1PDLIM5BioGRID26344197 details
MAP2K1PLIN3BioGRID26344197 details
MAP2K1RPEBioGRID26344197 details
MAP2K1PTPN11BioGRID26344197 details
MAP2K1CSNK1A1BioGRID27684187 details
MAP2K1HSP90AB1BioGRID27684187 details
MAP2K1RACK1BioGRID27684187 details
MAP2K1CLTCBioGRID27684187 details
MAP2K1TMPOBioGRID27684187 details
MAP2K1IGF1RBioGRID27684187 details
MAP2K1CAPN1BioGRID27684187 details
MAP2K1HNRNPA1BioGRID27684187 details
MAP2K1MCM3BioGRID27684187 details
MAP2K1PPP6CBioGRID27684187 details
MAP2K1JUPBioGRID27684187 details
MAP2K1PRDX6BioGRID27684187 details
MAP2K1RPS23BioGRID27684187 details
MAP2K1HSPH1BioGRID27684187 details
MAP2K1RPL8BioGRID27684187 details
MAP2K1PSMA1BioGRID27684187 details
MAP2K1RPL10BioGRID27684187 details
MAP2K1RPL7BioGRID27684187 details
MAP2K1HMGB1BioGRID27684187 details
MAP2K1SRPK1BioGRID27684187 details
MAP2K1PCNABioGRID27684187 details
MAP2K1CAND1BioGRID27684187 details
MAP2K1RPL35ABioGRID27684187 details
MAP2K1ATP5F1ABioGRID27684187 details
MAP2K1EEF1DBioGRID27684187 details
MAP2K1RPL7ABioGRID27684187 details
MAP2K1DNAH1BioGRID27684187 details
MAP2K1HNRNPKBioGRID27684187 details
MAP2K1DDX3XBioGRID27684187 details
MAP2K1HSP90AA1BioGRID27684187 details
MAP2K1RAB7ABioGRID27684187 details
MAP2K1PSMB6BioGRID27684187 details
MAP2K1RPS6BioGRID27684187 details
MAP2K1KPNB1BioGRID27684187 details
MAP2K1PSMD14BioGRID27684187 details
MAP2K1G6PDBioGRID27684187 details
MAP2K1PSAT1BioGRID27684187 details
MAP2K1ABCF1BioGRID27684187 details
MAP2K1SNAI1BioGRID29331416 details
MAP2K1TPT1BioGRID28846114 details
MAP2K1NR2C2BioGRID30463901 details
MAP2K1PLEKHA4BioGRID31091453 details
MAP2K1FAM20CBioGRID32149426 details
MAP2K1DNAJC1BioGRID33957083 details
MAP2K1RHOBBioGRID34079125 details
MAP2K1ELAVL1BioGRID19322201 details
MAP2K1TRIM25BioGRID29117863 details