Entity Details

Primary name SORL1
Entity type gene
Source Source Link

Details

PrimaryID6653
RefseqGeneNG_023313
SymbolSORL1
Namesortilin related receptor 1
Chromosome11
Location11q24.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-17
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsSORL_HUMAN

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001540 amyloid-beta binding
GO:0002024 diet induced thermogenesis
GO:0004888 transmembrane signaling receptor activity
GO:0005041 low-density lipoprotein particle receptor activity
GO:0005615 extracellular space
GO:0005641 nuclear envelope lumen
GO:0005768 endosome
GO:0005769 early endosome
GO:0005771 multivesicular body
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006605 protein targeting
GO:0006622 protein targeting to lysosome
GO:0006892 post-Golgi vesicle-mediated transport
GO:0006898 receptor-mediated endocytosis
GO:0007218 neuropeptide signaling pathway
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0010897 negative regulation of triglyceride catabolic process
GO:0014910 regulation of smooth muscle cell migration
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030169 low-density lipoprotein particle binding
GO:0030514 negative regulation of BMP signaling pathway
GO:0030658 transport vesicle membrane
GO:0031267 small GTPase binding
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031901 early endosome membrane
GO:0031985 Golgi cisterna
GO:0032091 negative regulation of protein binding
GO:0032585 multivesicular body membrane
GO:0034067 protein localization to Golgi apparatus
GO:0038020 insulin receptor recycling
GO:0042923 neuropeptide binding
GO:0043407 negative regulation of MAP kinase activity
GO:0045053 protein retention in Golgi apparatus
GO:0045732 positive regulation of protein catabolic process
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0050768 negative regulation of neurogenesis
GO:0051604 protein maturation
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
GO:0070062 extracellular exosome
GO:0070863 positive regulation of protein exit from endoplasmic reticulum
GO:0097356 perinucleolar compartment
GO:1900168 positive regulation of glial cell-derived neurotrophic factor production
GO:1901215 negative regulation of neuron death
GO:1902430 negative regulation of amyloid-beta formation
GO:1902771 positive regulation of choline O-acetyltransferase activity
GO:1902948 negative regulation of tau-protein kinase activity
GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport
GO:1902955 positive regulation of early endosome to recycling endosome transport
GO:1902960 negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902963 negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902966 positive regulation of protein localization to early endosome
GO:1902997 negative regulation of neurofibrillary tangle assembly
GO:1904179 positive regulation of adipose tissue development
GO:1990000 amyloid fibril formation
GO:1990845 adaptive thermogenesis
GO:2001137 positive regulation of endocytic recycling

Diseases

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Interactions

78 interactions

InteractorPartnerSourcesPublicationsLink
SORL1GGA1BioGRID, HPRD, MINT, UniProt11821067 17855360 20015111 26053850 30679749 details
SORL1GGA2BioGRID, HPRD, IntAct, MINT, UniProt11821067 30679749 32814053 details
SORL1PPP1CABioGRID, IntAct22321011 details
SORL1LRPAP1bhf-ucl, BioGRID, HPRD, IntAct11294867 11557679 17326667 26858303 28514442 8940146 details
SORL1APOEbhf-ucl, BioGRID11294867 17326667 details
SORL1DDIT4LIntAct32296183 details
SORL1RHOHBioGRID, IntAct32296183 details
SORL1POU6F2BioGRID, IntAct32296183 details
SORL1APPBioGRID, IntAct, UniProt16174740 16407538 17855360 23283322 32814053 details
SORL1HSPA12ABioGRID, UniProt30679749 details
SORL1CRLF1IntAct26858303 details
SORL1CNTFRIntAct26858303 details
SORL1IL6IntAct28265003 details
SORL1IL6RIntAct28265003 details
SORL1GDNFIntAct23333276 details
SORL1GFRA1IntAct23333276 details
SORL1CHRNA4IntAct32814053 details
SORL1NDUFV2IntAct32814053 details
SORL1CBX1IntAct32814053 details
SORL1PNPIntAct32814053 details
SORL1EIF2S2IntAct32814053 details
SORL1KAT5IntAct32814053 details
SORL1SORT1BioGRID11294867 details
SORL1SORL1BioGRID11294867 details
SORL1CEP97BioGRID, IntAct27173435 unassigned1312 details
SORL1RETIntAct23333276 details
SORL1PACS1BioGRID17855360 details
SORL1FURINHPRD11294867 details
SORL1CFTRBioGRID, IntAct17110338 details
SORL1DYRK3BioGRID, IntAct23602568 details
SORL1CUL1BioGRID, IntAct21145461 details
SORL1COPS5BioGRID, IntAct21145461 details
SORL1COPS6BioGRID, IntAct21145461 details
SORL1FOXI2BioGRID, MINT25609649 details
SORL1HLA-DPA1BioGRID, IntAct26186194 28514442 details
SORL1LGALS8BioGRID, IntAct26186194 28514442 details
SORL1SCGB1D1BioGRID, IntAct28514442 details
SORL1TAFA3BioGRID, IntAct28514442 details
SORL1ZNF169BioGRID, IntAct28514442 details
SORL1EGFL6BioGRID, IntAct28514442 details
SORL1GCNT3BioGRID, IntAct28514442 details
SORL1SOSTBioGRID, IntAct28514442 details
SORL1LGALS9BioGRID, IntAct26186194 28514442 details
SORL1AURKABioGRID, IntAct23443559 26186194 28514442 details
SORL1OS9BioGRID, IntAct28514442 details
SORL1ZFP41BioGRID, IntAct26186194 28514442 details
SORL1ZNF408BioGRID, IntAct28514442 details
SORL1TYW3BioGRID, IntAct28514442 details
SORL1DLDBioGRID, IntAct26186194 28514442 details
SORL1ZNF331BioGRID, IntAct28514442 details
SORL1TAFA4BioGRID, IntAct28514442 details
SORL1PSG1BioGRID, IntAct28514442 details
SORL1MDKBioGRID, IntAct28514442 details
SORL1ZNF264BioGRID, IntAct28514442 details
SORL1ZNF354CBioGRID, IntAct28514442 details
SORL1ZBBXBioGRID, IntAct28514442 details
SORL1FOSL2BioGRID, IntAct26186194 28514442 details
SORL1ZNF816BioGRID, IntAct28514442 details
SORL1ZNF563BioGRID, IntAct28514442 details
SORL1ZNF224BioGRID, IntAct28514442 details
SORL1ZNF517BioGRID, IntAct28514442 details
SORL1CDHR5BioGRID, IntAct28514442 details
SORL1SREBF1BioGRID, IntAct28514442 details
SORL1SP6BioGRID, IntAct26186194 28514442 details
SORL1ZNF549BioGRID, IntAct28514442 details
SORL1FAM76BBioGRID, IntAct26186194 28514442 details
SORL1FRMD6IntAct28514442 details
SORL1CD177UniProt21193407 details
SORL1DISC1BioGRID, MINT29961565 details
SORL1FBXO6BioGRID22268729 32409323 details
SORL1POP1BioGRID24778252 details
SORL1RSPO1BioGRID26186194 details
SORL1FGL1BioGRID26186194 details
SORL1CCN6BioGRID26186194 details
SORL1DUSP10BioGRID28675297 details
SORL1SLX4IPBioGRID31495888 details
SORL1BRWD3BioGRID31753913 details
SORL1SP110BioGRID31753913 details