Entity Details

Primary name TIMP1
Entity type gene
Source Source Link

Details

PrimaryID7076
RefseqGeneNG_008437
SymbolTIMP1
NameTIMP metallopeptidase inhibitor 1
ChromosomeX
LocationXp11.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-24
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsTIMP1_HUMAN

GO terms

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GOName
GO:0001775 cell activation
GO:0002020 protease binding
GO:0002248 connective tissue replacement involved in inflammatory response wound healing
GO:0002576 platelet degranulation
GO:0004857 enzyme inhibitor activity
GO:0005125 cytokine activity
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0007568 aging
GO:0008083 growth factor activity
GO:0008191 metalloendopeptidase inhibitor activity
GO:0008270 zinc ion binding
GO:0008284 positive regulation of cell population proliferation
GO:0009725 response to hormone
GO:0010033 response to organic substance
GO:0010951 negative regulation of endopeptidase activity
GO:0019221 cytokine-mediated signaling pathway
GO:0022617 extracellular matrix disassembly
GO:0030414 peptidase inhibitor activity
GO:0031012 extracellular matrix
GO:0031093 platelet alpha granule lumen
GO:0034097 response to cytokine
GO:0043066 negative regulation of apoptotic process
GO:0043086 negative regulation of catalytic activity
GO:0043434 response to peptide hormone
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0051045 negative regulation of membrane protein ectodomain proteolysis
GO:0051216 cartilage development
GO:0070062 extracellular exosome
GO:0071492 cellular response to UV-A
GO:1901164 negative regulation of trophoblast cell migration
GO:1905049 negative regulation of metallopeptidase activity
GO:2001044 regulation of integrin-mediated signaling pathway

Diseases

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Interactions

19 interactions

InteractorPartnerSourcesPublicationsLink
TIMP1ECH1BioGRID, HPRD, IntAct16169070 details
TIMP1EEF1B2BioGRID, HPRD, IntAct16169070 details
TIMP1RECQL5BioGRID, HPRD, IntAct16169070 details
TIMP1CD63BioGRID, HPRD, IntAct, MINT16917503 24635319 28030805 29523123 details
TIMP1CD82IntAct28030805 details
TIMP1TIMP1IntAct28030805 details
TIMP1MMP9BioGRID, IntAct24330623 28514442 details
TIMP1COL5A1matrixdb20979576 details
TIMP1MMP14BioGRID, IntAct26264872 32814053 8804434 details
TIMP1MMP1BioGRID, HPRD9063449 details
TIMP1MYOCBioGRID, HPRD16289162 details
TIMP1ZBTB16BioGRID17340613 details
TIMP1SUMO2IntAct16169070 details
TIMP1MMP3BioGRID, HPRD12834347 9288970 details
TIMP1MMP2HPRD12475252 details
TIMP1FGFR2BioGRID, IntAct28514442 details
TIMP1IGFBP1BioGRID, IntAct28514442 details
TIMP1MMP10BioGRID, IntAct28514442 details
TIMP1FBXO6BioGRID22268729 32409323 details