Entity Details

Primary name TLR2
Entity type gene
Source Source Link

Details

PrimaryID7097
RefseqGeneNG_016229
SymbolTLR2
Nametoll like receptor 2
Chromosome4
Location4q31.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-12-15
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsTLR2_HUMAN

GO terms

Show/Hide Table
GOName
GO:0001530 lipopolysaccharide binding
GO:0001540 amyloid-beta binding
GO:0001666 response to hypoxia
GO:0001774 microglial cell activation
GO:0001775 cell activation
GO:0001875 lipopolysaccharide immune receptor activity
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0004888 transmembrane signaling receptor activity
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006691 leukotriene metabolic process
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007252 I-kappaB phosphorylation
GO:0007612 learning
GO:0008285 negative regulation of cell population proliferation
GO:0009636 response to toxic substance
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0014005 microglia development
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030667 secretory granule membrane
GO:0030670 phagocytic vesicle membrane
GO:0031226 intrinsic component of plasma membrane
GO:0032289 central nervous system myelin formation
GO:0032570 response to progesterone
GO:0032613 interleukin-10 production
GO:0032722 positive regulation of chemokine production
GO:0032728 positive regulation of interferon-beta production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032741 positive regulation of interleukin-18 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032868 response to insulin
GO:0034123 positive regulation of toll-like receptor signaling pathway
GO:0034134 toll-like receptor 2 signaling pathway
GO:0035325 Toll-like receptor binding
GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex
GO:0038023 signaling receptor activity
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0038187 pattern recognition receptor activity
GO:0042495 detection of triacyl bacterial lipopeptide
GO:0042496 detection of diacyl bacterial lipopeptide
GO:0042497 triacyl lipopeptide binding
GO:0042802 identical protein binding
GO:0042834 peptidoglycan binding
GO:0042995 cell projection
GO:0043312 neutrophil degranulation
GO:0044297 cell body
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046209 nitric oxide metabolic process
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0050135 NAD(P)+ nucleosidase activity
GO:0050729 positive regulation of inflammatory response
GO:0050765 negative regulation of phagocytosis
GO:0050830 defense response to Gram-positive bacterium
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051607 defense response to virus
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0051964 negative regulation of synapse assembly
GO:0052031 modulation by symbiont of host defense response
GO:0061809 NAD+ nucleotidase, cyclic ADP-ribose generating
GO:0070542 response to fatty acid
GO:0071221 cellular response to bacterial lipopeptide
GO:0071223 cellular response to lipoteichoic acid
GO:0071346 cellular response to interferon-gamma
GO:0071726 cellular response to diacyl bacterial lipopeptide
GO:0071727 cellular response to triacyl bacterial lipopeptide
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1903974 positive regulation of cellular response to macrophage colony-stimulating factor stimulus
GO:1904466 positive regulation of matrix metallopeptidase secretion

Diseases

Show/Hide Table

Interactions

52 interactions

InteractorPartnerSourcesPublicationsLink
TLR2MYD88BioGRID, HPRD, IntAct, MINT, UniProt15107846 16293622 16482509 17126326 29990310 details
TLR2EGFRBioGRID, IntAct, MINT17126326 24658140 25402006 31980649 details
TLR2CXCR4DIP, I2D18765807 20802527 details
TLR2PIK3R1HPRD, MINT15007072 23247210 details
TLR2ATG16L1BioGRID, MINT23376921 27273576 29634390 details
TLR2AKT1BioGRID, MINT24412244 details
TLR2ANP32BBioGRID, MINT24412244 details
TLR2FBP1BioGRID, MINT24412244 details
TLR2HEMGNBioGRID, MINT24412244 details
TLR2MAP2K1BioGRID, MINT24412244 details
TLR2NANSBioGRID, MINT24412244 details
TLR2SMAD1BioGRID, MINT24412244 details
TLR2STX17BioGRID, MINT24412244 details
TLR2TGFB1BioGRID, MINT24412244 details
TLR2TMOD1BioGRID, MINT24412244 details
TLR2BGNmatrixdb24480070 details
TLR2TIRAPBioGRID, IntAct17258210 18221795 details
TLR2CD14BioGRID, DIP, HPRD10395652 18765807 details
TLR2SIGLEC5IntAct25187624 details
TLR2SIGLEC9IntAct25187624 details
TLR2TLR10HPRD, IntAct15728506 23155421 details
TLR2TLR2BioGRID, IntAct10395652 23155421 details
TLR2TLR1BioGRID, HPRD, IntAct12077222 23155421 details
TLR2TLR6HPRD, IntAct, MINT12077222 20067962 23155421 details
TLR2TOLLIPBioGRID, HPRD11751856 details
TLR2TRIM58BioGRID31383741 details
TLR2HMGB1HPRD, MINT16267105 20067962 details
TLR2LY96BioGRID, HPRD11160242 details
TLR2IRAK1BioGRID, HPRD10395652 details
TLR2CLEC4MBioGRID21899704 details
TLR2CLEC7ABioGRID21899704 details
TLR2CREBBPBioGRID17126870 details
TLR2IRF3BioGRID17126870 details
TLR2PIK3AP1BioGRID27909057 details
TLR2RIPK2BioGRID, HPRD11894098 32909611 details
TLR2HSP90B1HPRD11912201 details
TLR2SFTPA1HPRD11724772 details
TLR2HRASHPRD15496409 details
TLR2RAC1HPRD11101877 details
TLR2TRIP6HPRD15657077 details
TLR2TICAM1HPRD12471095 details
TLR2MAPK8IP3HPRD12941697 details
TLR2AP1M1BioGRID, IntAct28514442 details
TLR2LGR4BioGRID, IntAct28514442 details
TLR2USP33BioGRID, IntAct28514442 details
TLR2STK11IPBioGRID, IntAct28514442 details
TLR2ITPRIPBioGRID, IntAct28514442 details
TLR2TMEM214BioGRID, IntAct28514442 details
TLR2STAT5ABioGRID, IntAct28514442 details
TLR2BMPR1ABioGRID, IntAct28514442 details
TLR2ACVR2ABioGRID, IntAct28514442 details
TLR2HSPD1MINT20067962 details