Entity Details

Primary name TOP3A
Entity type gene
Source Source Link

Details

PrimaryID7156
RefseqGene
SymbolTOP3A
NameDNA topoisomerase III alpha
Chromosome17
Location17p11.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-07-21
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsTOP3A_HUMAN

GO terms

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GOName
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005759 mitochondrial matrix
GO:0006260 DNA replication
GO:0006265 DNA topological change
GO:0008270 zinc ion binding
GO:0016605 PML body
GO:0032042 mitochondrial DNA metabolic process
GO:0051304 chromosome separation
GO:0051321 meiotic cell cycle
GO:1901796 regulation of signal transduction by p53 class mediator

Diseases

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Interactions

67 interactions

InteractorPartnerSourcesPublicationsLink
TOP3ARMI1BioGRID, DIP, IntAct, MINT, UniProt15775963 16537486 20064461 20360068 20711169 20826342 24509834 26186194 28514442 details
TOP3ABLMBioGRID, HPRD, IntAct, MINT, UniProt10734115 10825162 11406610 11470874 12724401 15775963 20360068 20711169 23509288 24239288 26496610 30279242 details
TOP3AFANCMBioGRID16116422 20064461 24699063 details
TOP3ATSNAXBioGRID21466675 details
TOP3ATDRD3BioGRID28176834 details
TOP3ATERF2BioGRID, MINT18418389 details
TOP3APMLMINT18418389 details
TOP3ATINF2MINT18418389 details
TOP3AFANCABioGRID, MINT12724401 12973351 21240188 22343915 22705371 details
TOP3ARPA2BioGRID, MINT24126761 24332808 30279242 details
TOP3ARPA1BioGRID, MINT12724401 24126761 24332808 details
TOP3ARECQL5BioGRID, HPRD10710432 details
TOP3ACENPSBioGRID20347429 24699063 details
TOP3AFANCGBioGRID12724401 details
TOP3AMIB1BioGRID24239288 details
TOP3AFANCD2BioGRID25659033 31180492 details
TOP3AHERC2BioGRID30279242 details
TOP3AETAA1BioGRID27723720 details
TOP3AERCC6LIntAct20360068 details
TOP3APLK1IntAct20360068 details
TOP3ARIF1MINT20711169 details
TOP3ATP53MINT22653443 details
TOP3ARPA3BioGRID, MINT24126761 24332808 details
TOP3AEGLN3BioGRID, IntAct26972000 details
TOP3ACEP162BioGRID, IntAct26638075 details
TOP3ABPNT1BioGRID, IntAct28514442 details
TOP3AMECP2BioGRID, IntAct28514442 details
TOP3AODAPHBioGRID, IntAct28514442 details
TOP3AOXLD1BioGRID, IntAct26186194 28514442 details
TOP3ANIT1BioGRID, IntAct28514442 details
TOP3AYBEYBioGRID, IntAct28514442 details
TOP3AATP5F1DBioGRID, IntAct28514442 details
TOP3AECHDC2BioGRID, IntAct26186194 28514442 details
TOP3AMRPL21BioGRID, IntAct28514442 details
TOP3ASLX1ABioGRID, IntAct28514442 details
TOP3ASLX1BIntAct28514442 details
TOP3ATHEM4BioGRID, IntAct28514442 details
TOP3AMARCKSL1BioGRID, IntAct28514442 details
TOP3AMETTL2ABioGRID, IntAct28514442 details
TOP3ALIG3BioGRID, IntAct26186194 28514442 details
TOP3ASDHBBioGRID, IntAct28514442 details
TOP3ACOX7A2BioGRID, IntAct28514442 details
TOP3ATMEM70BioGRID, IntAct28514442 details
TOP3ARMI2BioGRID, DIP, IntAct20826341 20826342 26186194 28514442 details
TOP3ABRCA1BioGRID, UniProt29656893 details
TOP3ASHLD2UniProt29789392 details
TOP3ASPIDRBioGRID, UniProt23509288 details
TOP3ARAD21BioGRID22145905 details
TOP3ALSM11BioGRID22939629 details
TOP3AFAAP100BioGRID22343915 details
TOP3AMRM1BioGRID26186194 details
TOP3ADCUN1D4BioGRID26344197 details
TOP3ATTF2BioGRID26344197 details
TOP3ANTRK1BioGRID25921289 details
TOP3ACCDC69BioGRID28514442 details
TOP3ASNAI1BioGRID29331416 details
TOP3AFBXO38BioGRID30804394 details
TOP3AH4C1BioGRID30804502 details
TOP3APLEKHA4BioGRID31091453 details
TOP3AMETTL17BioGRID32877691 details
TOP3AMTIF2BioGRID32877691 details
TOP3AMTRF1BioGRID32877691 details
TOP3ASSBP1BioGRID32877691 details
TOP3ATSFMBioGRID32877691 details
TOP3ATMEM79BioGRID32924931 details
TOP3AAARS2BioGRID34079125 details
TOP3APDHA1BioGRID34079125 details