Entity Details

Primary name VEGFA
Entity type gene
Source Source Link

Details

PrimaryID7422
RefseqGeneNG_008732
SymbolVEGFA
Namevascular endothelial growth factor A
Chromosome6
Location6p21.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-25
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsVEGFA_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001525 angiogenesis
GO:0001541 ovarian follicle development
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001570 vasculogenesis
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001822 kidney development
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001968 fibronectin binding
GO:0002040 sprouting angiogenesis
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0002052 positive regulation of neuroblast proliferation
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002092 positive regulation of receptor internalization
GO:0002575 basophil chemotaxis
GO:0002576 platelet degranulation
GO:0002687 positive regulation of leukocyte migration
GO:0003007 heart morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003169 coronary vein morphogenesis
GO:0005125 cytokine activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005172 vascular endothelial growth factor receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005912 adherens junction
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007399 nervous system development
GO:0007498 mesoderm development
GO:0007595 lactation
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0008284 positive regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0009986 cell surface
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010749 regulation of nitric oxide mediated signal transduction
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0030141 secretory granule
GO:0030224 monocyte differentiation
GO:0030225 macrophage differentiation
GO:0030324 lung development
GO:0030335 positive regulation of cell migration
GO:0030855 epithelial cell differentiation
GO:0031012 extracellular matrix
GO:0031077 post-embryonic camera-type eye development
GO:0031093 platelet alpha granule lumen
GO:0031334 positive regulation of protein-containing complex assembly
GO:0031954 positive regulation of protein autophosphorylation
GO:0032147 activation of protein kinase activity
GO:0032793 positive regulation of CREB transcription factor activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035148 tube formation
GO:0035767 endothelial cell chemotaxis
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0036303 lymph vessel morphogenesis
GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway
GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0038084 vascular endothelial growth factor signaling pathway
GO:0038089 positive regulation of cell migration by vascular endothelial growth factor signaling pathway
GO:0038091 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0038190 VEGF-activated neuropilin signaling pathway
GO:0038191 neuropilin binding
GO:0042056 chemoattractant activity
GO:0042327 positive regulation of phosphorylation
GO:0042462 eye photoreceptor cell development
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0043117 positive regulation of vascular permeability
GO:0043129 surfactant homeostasis
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043183 vascular endothelial growth factor receptor 1 binding
GO:0043184 vascular endothelial growth factor receptor 2 binding
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045766 positive regulation of angiogenesis
GO:0045785 positive regulation of cell adhesion
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048018 receptor ligand activity
GO:0048469 cell maturation
GO:0048593 camera-type eye morphogenesis
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048842 positive regulation of axon extension involved in axon guidance
GO:0048844 artery morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050840 extracellular matrix binding
GO:0050918 positive chemotaxis
GO:0050927 positive regulation of positive chemotaxis
GO:0050930 induction of positive chemotaxis
GO:0051272 positive regulation of cellular component movement
GO:0051781 positive regulation of cell division
GO:0051894 positive regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0060319 primitive erythrocyte differentiation
GO:0060749 mammary gland alveolus development
GO:0060754 positive regulation of mast cell chemotaxis
GO:0060948 cardiac vascular smooth muscle cell development
GO:0060982 coronary artery morphogenesis
GO:0061042 vascular wound healing
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071456 cellular response to hypoxia
GO:0071542 dopaminergic neuron differentiation
GO:0071679 commissural neuron axon guidance
GO:0090037 positive regulation of protein kinase C signaling
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:0090259 regulation of retinal ganglion cell axon guidance
GO:0097475 motor neuron migration
GO:0097533 cellular stress response to acid chemical
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation
GO:1900745 positive regulation of p38MAPK cascade
GO:1901165 positive regulation of trophoblast cell migration
GO:1901727 positive regulation of histone deacetylase activity
GO:1902336 positive regulation of retinal ganglion cell axon guidance
GO:1902966 positive regulation of protein localization to early endosome
GO:1903141 negative regulation of establishment of endothelial barrier
GO:1903392 negative regulation of adherens junction organization
GO:1903572 positive regulation of protein kinase D signaling
GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:1903672 positive regulation of sprouting angiogenesis
GO:1905278 positive regulation of epithelial tube formation
GO:1905604 negative regulation of blood-brain barrier permeability
GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin
GO:2000573 positive regulation of DNA biosynthetic process

Diseases

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Interactions

67 interactions

InteractorPartnerSourcesPublicationsLink
VEGFAKDRbhf-ucl, BioGRID, DIP, HPRD, IntAct, matrixdb, MINT12716911 1417831 16423422 16763549 16901919 17318185 18325345 19818105 20145116 20660291 21596751 22897854 23374253 23583373 25644401 28303365 30236477 31932617 8621427 details
VEGFANRP1BioGRID, HPRD, IntAct, MINT10409677 11886873 11986311 16423422 16763549 17222790 18325345 20363638 21939755 22318724 22897854 26804163 30236477 9529250 details
VEGFAFLT1bhf-ucl, BioGRID, HPRD, IntAct, matrixdb10543948 1312256 17051153 18593464 20660291 21596751 21939755 28514442 8621427 9393862 details
VEGFAU2AF1L5IntAct21988832 details
VEGFAU2AF1BioGRID, IntAct21988832 details
VEGFAVPS35BioGRID, IntAct21988832 details
VEGFAPRRG4BioGRID, IntAct21988832 details
VEGFAHIF1ABioGRID, I2D, IntAct11901189 17413038 21602890 21620138 22952674 23549086 23928995 23991099 24434214 24656772 details
VEGFAVEGFAbhf-ucl, BioGRID, HPRD, IntAct, MINT10748121 12086892 12207021 1312256 22897854 25132001 30236477 8631822 9207067 details
VEGFAUBIAD1BioGRID, UniProt23169578 details
VEGFALCN2IntAct32296183 details
VEGFAGJB1BioGRID, IntAct32296183 details
VEGFASLC35C2BioGRID, IntAct32296183 details
VEGFATMEM237BioGRID, IntAct32296183 details
VEGFAADAMTS1BioGRID, HPRD12716911 details
VEGFACCN2BioGRID, HPRD11744618 details
VEGFAIGFBP7BioGRID, HPRD12407018 details
VEGFASPARCBioGRID, HPRD25921830 9792673 details
VEGFAVTNBioGRID, HPRD11796824 details
VEGFAGPC1BioGRID, HPRD10196157 details
VEGFACRYABBioGRID17487982 21984182 details
VEGFALYVE1BioGRID7829517 details
VEGFANRP2BioGRID, HPRD10748121 17595163 details
VEGFAFN1BioGRID12114318 details
VEGFASP1BioGRID15342781 details
VEGFASP3BioGRID15342781 details
VEGFATFAP2ABioGRID15342781 details
VEGFASLC16A2BioGRID32296183 details
VEGFAVEGFBBioGRID, HPRD, IntAct25241761 26186194 28514442 8702615 details
VEGFAPGFBioGRID, HPRD, IntAct12086892 12796773 25241761 details
VEGFASTAT3BioGRID, IntAct23750211 23991099 details
VEGFATHBS1DIP19805200 details
VEGFAHSP90AA1BioGRID18211808 details
VEGFAHSPA4BioGRID18211808 23109422 details
VEGFAHGSBioGRID17445799 details
VEGFAPTPRBBioGRID25644401 details
VEGFAPTPRZ1BioGRID25644401 details
VEGFACLUBioGRID26716898 details
VEGFAUSF2BioGRID23991099 details
VEGFAFOSBioGRID23549086 details
VEGFAARNTBioGRID17413038 25879517 details
VEGFASEMA3FHPRD12845630 details
VEGFATNXBHPRD11122379 details
VEGFAEPHB2HPRD17318185 details
VEGFAAKT1HPRD17318185 details
VEGFAYBX3HPRD16198352 details
VEGFAYBX1HPRD16198352 details
VEGFAANGPT2IntAct20708158 details
VEGFAPDGFBbhf-ucl17470632 details
VEGFAPDGFRAbhf-ucl17470632 details
VEGFAPDGFRBbhf-ucl17470632 details
VEGFAACTBL2BioGRID, IntAct28514442 details
VEGFANCBP3IntAct26382858 details
VEGFAEP300IntAct20609350 details
VEGFAEPAS1IntAct21620138 details
VEGFACREBBPI2D21602890 details
VEGFACBX4IntAct24434214 details
VEGFARELAIntAct24413684 details
VEGFACREB1IntAct26350463 details
VEGFAELAVL1BioGRID16170373 22086907 details
VEGFAHNRNPDBioGRID22086907 23109422 details
VEGFAHNRNPLBioGRID23976881 details
VEGFAILF3BioGRID23976881 details
VEGFAMDM2BioGRID28274247 details
VEGFAAPEX1BioGRID28986522 details
VEGFAHNRNPH1BioGRID26760575 details
VEGFADDX58BioGRID32513696 details