Entity Details

Primary name HMGA2
Entity type gene
Source Source Link

Details

PrimaryID8091
RefseqGeneNG_016296
SymbolHMGA2
Namehigh mobility group AT-hook 2
Chromosome12
Location12q14.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-11-07
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsHMGA2_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000228 nuclear chromosome
GO:0000976 transcription cis-regulatory region binding
GO:0001837 epithelial to mesenchymal transition
GO:0002062 chondrocyte differentiation
GO:0003131 mesodermal-endodermal cell signaling
GO:0003680 minor groove of adenine-thymine-rich DNA binding
GO:0003712 transcription coregulator activity
GO:0003714 transcription corepressor activity
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006284 base-excision repair
GO:0006325 chromatin organization
GO:0006355 regulation of transcription, DNA-templated
GO:0007095 mitotic G2 DNA damage checkpoint signaling
GO:0007275 multicellular organism development
GO:0008134 transcription factor binding
GO:0008301 DNA binding, bending
GO:0009615 response to virus
GO:0010564 regulation of cell cycle process
GO:0010628 positive regulation of gene expression
GO:0030261 chromosome condensation
GO:0031052 chromosome breakage
GO:0031492 nucleosomal DNA binding
GO:0031507 heterochromatin assembly
GO:0032993 protein-DNA complex
GO:0035497 cAMP response element binding
GO:0035500 MH2 domain binding
GO:0035501 MH1 domain binding
GO:0035978 histone H2A-S139 phosphorylation
GO:0035985 senescence-associated heterochromatin focus
GO:0035986 senescence-associated heterochromatin focus assembly
GO:0035987 endodermal cell differentiation
GO:0035988 chondrocyte proliferation
GO:0040008 regulation of growth
GO:0042769 DNA damage response, detection of DNA damage
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0043922 negative regulation by host of viral transcription
GO:0045444 fat cell differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046332 SMAD binding
GO:0048333 mesodermal cell differentiation
GO:0048762 mesenchymal cell differentiation
GO:0048863 stem cell differentiation
GO:0051301 cell division
GO:0051575 5'-deoxyribose-5-phosphate lyase activity
GO:0070742 C2H2 zinc finger domain binding
GO:0071141 SMAD protein complex
GO:0071864 positive regulation of cell proliferation in bone marrow
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090402 oncogene-induced cell senescence
GO:2000036 regulation of stem cell population maintenance
GO:2000648 positive regulation of stem cell proliferation
GO:2000685 positive regulation of cellular response to X-ray
GO:2000773 negative regulation of cellular senescence
GO:2000774 positive regulation of cellular senescence
GO:2001022 positive regulation of response to DNA damage stimulus
GO:2001033 negative regulation of double-strand break repair via nonhomologous end joining
GO:2001038 regulation of cellular response to drug

Diseases

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Interactions

60 interactions

InteractorPartnerSourcesPublicationsLink
HMGA2PRMT6BioGRID, IntAct16293633 details
HMGA2RELABioGRID, HPRD12693954 details
HMGA2NFKB1BioGRID, HPRD12693954 details
HMGA2PIAS3BioGRID, HPRD11390395 details
HMGA2RB1BioGRID16766265 details
HMGA2NPM1BioGRID16293633 18850631 details
HMGA2PRKCABioGRID10889043 details
HMGA2PTBP1BioGRID18850631 details
HMGA2APEX1BioGRID18850631 details
HMGA2SYNCRIPBioGRID18850631 details
HMGA2XRCC6BioGRID18850631 details
HMGA2PSIP1BioGRID18850631 details
HMGA2PA2G4BioGRID18850631 details
HMGA2PCBP2BioGRID18850631 details
HMGA2E4F1BioGRID14645522 details
HMGA2TP53BioGRID30175854 details
HMGA2MDM2BioGRID30175854 details
HMGA2KAT2BBioGRID32313942 details
HMGA2RUNX1IntAct29391048 details
HMGA2SMAD1BioGRID18425117 details
HMGA2SMAD5BioGRID18425117 details
HMGA2SMAD9BioGRID18425117 details
HMGA2CSNK2A1HPRD11034995 details
HMGA2CSNK2A2HPRD11034995 details
HMGA2CDK1HPRD10636877 details
HMGA2SMAD3HPRD18832382 details
HMGA2PRMT1IntAct16293633 details
HMGA2H2AXIntAct26045162 details
HMGA2ATMIntAct26045162 details
HMGA2CREB1BioGRID, MINT25609649 details
HMGA2NFATC1BioGRID, MINT25609649 details
HMGA2DUX4BioGRID, IntAct26816005 details
HMGA2DLSTBioGRID, IntAct29128334 details
HMGA2H1-5BioGRID, IntAct30021884 details
HMGA2H3C1BioGRID, MINT25281560 34079125 details
HMGA2H3C4MINT25281560 details
HMGA2H3C3MINT25281560 details
HMGA2H3C6MINT25281560 details
HMGA2H3C11MINT25281560 details
HMGA2H3C8MINT25281560 details
HMGA2H3C12MINT25281560 details
HMGA2H3C10MINT25281560 details
HMGA2H3C2MINT25281560 details
HMGA2H3C7MINT25281560 details
HMGA2SYDE1BioGRID, IntAct32203420 details
HMGA2HDGFBioGRID21907836 details
HMGA2OBSL1BioGRID24711643 details
HMGA2PCGF1BioGRID26687479 details
HMGA2POU5F1BioGRID26687479 details
HMGA2EZH2BioGRID27634302 details
HMGA2SUZ12BioGRID27634302 details
HMGA2MYCBioGRID29467282 details
HMGA2VRK1BioGRID28927264 details
HMGA2PRKAG2BioGRID31900314 details
HMGA2ARHGAP21BioGRID32203420 details
HMGA2ARHGAP39BioGRID32203420 details
HMGA2ZNF263BioGRID32051553 details
HMGA2MAFBBioGRID31822558 details
HMGA2H2BC8BioGRID34079125 details
HMGA2LMNB1BioGRID34079125 details