Entity Details

Primary name SPHK1
Entity type gene
Source Source Link

Details

PrimaryID8877
RefseqGene
SymbolSPHK1
Namesphingosine kinase 1
Chromosome17
Location17q25.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-01-29
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsSPHK1_HUMAN

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0001568 blood vessel development
GO:0001727 lipid kinase activity
GO:0003677 DNA binding
GO:0003951 NAD+ kinase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0006457 protein folding
GO:0006473 protein acetylation
GO:0006665 sphingolipid metabolic process
GO:0006670 sphingosine metabolic process
GO:0006954 inflammatory response
GO:0007420 brain development
GO:0008289 lipid binding
GO:0008481 sphinganine kinase activity
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0016020 membrane
GO:0016310 phosphorylation
GO:0016407 acetyltransferase activity
GO:0017050 D-erythro-sphingosine kinase activity
GO:0019722 calcium-mediated signaling
GO:0030100 regulation of endocytosis
GO:0030139 endocytic vesicle
GO:0030148 sphingolipid biosynthetic process
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0031398 positive regulation of protein ubiquitination
GO:0031901 early endosome membrane
GO:0032651 regulation of interleukin-1 beta production
GO:0032740 positive regulation of interleukin-17 production
GO:0034612 response to tumor necrosis factor
GO:0035556 intracellular signal transduction
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0038036 sphingosine-1-phosphate receptor activity
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0045766 positive regulation of angiogenesis
GO:0045840 positive regulation of mitotic nuclear division
GO:0045931 positive regulation of mitotic cell cycle
GO:0045987 positive regulation of smooth muscle contraction
GO:0046512 sphingosine biosynthetic process
GO:0046521 sphingoid catabolic process
GO:0048146 positive regulation of fibroblast proliferation
GO:0050764 regulation of phagocytosis
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051721 protein phosphatase 2A binding
GO:0070301 cellular response to hydrogen peroxide
GO:0071363 cellular response to growth factor stimulus
GO:0071897 DNA biosynthetic process
GO:0098793 presynapse
GO:0150077 regulation of neuroinflammatory response
GO:1900060 negative regulation of ceramide biosynthetic process
GO:1900745 positive regulation of p38MAPK cascade
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1903978 regulation of microglial cell activation
GO:1905364 regulation of endosomal vesicle fusion

Diseases

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Interactions

85 interactions

InteractorPartnerSourcesPublicationsLink
SPHK1FYNHPRD, IntAct16316995 details
SPHK1CTSBHPRD, MINT15710602 17064696 details
SPHK1FHL2IntAct16888242 details
SPHK1SPHKAPHPRD, UniProt12080051 details
SPHK1EEF1A1I2D20838377 details
SPHK1RARGBioGRID, IntAct21988832 details
SPHK1EP300BioGRID, IntAct22227192 24759103 details
SPHK1LAMP2IntAct32814053 details
SPHK1SH3GLB1IntAct32814053 details
SPHK1RPS6KC1BioGRID, HPRD12077123 details
SPHK1TRAF2BioGRID, HPRD11777919 25716317 28521610 details
SPHK1MBTPS1BioGRID17124500 details
SPHK1BIRC3BioGRID24464131 details
SPHK1CTNND2HPRD15193146 details
SPHK1TRAF6BioGRID, HPRD, MINT17124500 details
SPHK1BECN1BioGRID28521610 details
SPHK1KLHL5BioGRID31652307 details
SPHK1LYNHPRD16316995 details
SPHK1HUWE1IntAct25216046 details
SPHK1CITIntAct25216046 details
SPHK1SQSTM1IntAct25216046 details
SPHK1OATIntAct25216046 details
SPHK1ACTG1IntAct25216046 details
SPHK1GRB2IntAct25216046 details
SPHK1MYO1DIntAct25216046 details
SPHK1MAD2L1IntAct25216046 details
SPHK1PSMB2IntAct25216046 details
SPHK1PSMA3IntAct25216046 details
SPHK1ACTBIntAct25216046 details
SPHK1STAU1IntAct25216046 details
SPHK1TAF4IntAct25216046 details
SPHK1ROCK2IntAct25216046 details
SPHK1MARCKSL1IntAct25216046 details
SPHK1DPM1IntAct25216046 details
SPHK1ARPC3IntAct25216046 details
SPHK1PSMA8IntAct25216046 details
SPHK1LTBP1IntAct25216046 details
SPHK1PSMB6IntAct25216046 details
SPHK1DPP7IntAct25216046 details
SPHK1ARPC5LIntAct25216046 details
SPHK1DCXRBioGRID, IntAct25216046 26186194 28514442 details
SPHK1BAG2IntAct25216046 details
SPHK1PPM1GBioGRID, IntAct25216046 26186194 details
SPHK1AIF1LIntAct25216046 details
SPHK1DBN1IntAct25216046 details
SPHK1MYO1BIntAct25216046 details
SPHK1SVILIntAct25216046 details
SPHK1HSPA8IntAct25216046 details
SPHK1GALK1IntAct25216046 details
SPHK1PPP2R2AIntAct25216046 details
SPHK1PRMT1IntAct25216046 details
SPHK1RAB35IntAct25216046 details
SPHK1TUFMIntAct25216046 details
SPHK1HNRNPA2B1IntAct25216046 details
SPHK1PCK2IntAct25216046 details
SPHK1HP1BP3IntAct25216046 details
SPHK1MYO1CIntAct25216046 details
SPHK1RBM3IntAct25216046 details
SPHK1MYH9IntAct25216046 details
SPHK1LAD1IntAct25216046 details
SPHK1DSTNIntAct25216046 details
SPHK1TMOD3IntAct25216046 details
SPHK1PDZK1IntAct25216046 details
SPHK1CSRP1IntAct25216046 details
SPHK1LLGL2IntAct25216046 details
SPHK1ACACAIntAct25216046 details
SPHK1ARMCX3IntAct25216046 details
SPHK1CYLDBioGRID, IntAct26186194 28514442 details
SPHK1DHPSBioGRID, IntAct26186194 28514442 details
SPHK1H4-16IntAct24759103 details
SPHK1H4C15IntAct24759103 details
SPHK1H4C9IntAct24759103 details
SPHK1H4C1IntAct24759103 details
SPHK1H4C4IntAct24759103 details
SPHK1H4C6IntAct24759103 details
SPHK1H4C12IntAct24759103 details
SPHK1H4C11IntAct24759103 details
SPHK1H4C3IntAct24759103 details
SPHK1H4C8IntAct24759103 details
SPHK1H4C2IntAct24759103 details
SPHK1H4C5IntAct24759103 details
SPHK1H4C13IntAct24759103 details
SPHK1H4C14IntAct24759103 details
SPHK1SP6IntAct24759103 details
SPHK1DDX58BioGRID32513696 details