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Entity Details
Primary name
SHC4_HUMAN
Entity type
UniProt
Source
Source Link
Details
Accession
Q6S5L8
EntryName
SHC4_HUMAN
FullName
SHC-transforming protein 4
TaxID
9606
Evidence
evidence at protein level
Length
630
SequenceStatus
complete
DateCreated
2008-05-20
DateModified
2021-06-02
Ontological Relatives
Genes
SHC4
GO terms
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GO
Name
GO:0005886
plasma membrane
GO:0006915
apoptotic process
GO:0007169
transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284
positive regulation of cell population proliferation
GO:0010468
regulation of gene expression
GO:0019901
protein kinase binding
GO:0019904
protein domain specific binding
GO:0030971
receptor tyrosine kinase binding
GO:0035556
intracellular signal transduction
GO:0045211
postsynaptic membrane
GO:0048863
stem cell differentiation
Subcellular Location
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Subcellular Location
Cell junction
Domains
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Domain
Name
Category
Type
IPR000980
SH2 domain
Domain
Domain
IPR006019
Phosphotyrosine interaction domain, Shc-like
Domain
Domain
IPR006020
PTB/PI domain
Domain
Domain
IPR011993
PH-like domain superfamily
Family
Homologous superfamily
IPR029596
SHC-transforming protein 4
Family
Family
IPR035676
SH2 adaptor protein C, SH2 domain
Domain
Domain
IPR036860
SH2 domain superfamily
Family
Homologous superfamily
Diseases
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Drugs
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Interactions
13 interactions
Interactor
Partner
Sources
Publications
Link
SHC4_HUMAN
ANDR_HUMAN
BioGRID, IntAct
24728074
details
SHC4_HUMAN
KIT_HUMAN
BioGRID, IntAct
24728074
details
SHC4_HUMAN
MET_HUMAN
BioGRID, IntAct
24728074
details
SHC4_HUMAN
EGFR_HUMAN
BioGRID, IntAct
22973453
24430869
24658140
25402006
28724758
31980649
details
SHC4_HUMAN
RET_HUMAN
BioGRID
28213521
details
SHC4_HUMAN
ERBB2_HUMAN
BioGRID
22973453
details
SHC4_HUMAN
ERBB3_HUMAN
BioGRID
22973453
details
SHC4_HUMAN
ERBB4_HUMAN
BioGRID
22973453
details
SHC4_HUMAN
GRB2_HUMAN
BioGRID, HPRD
17409413
24430869
28213521
details
SHC4_HUMAN
CBL_HUMAN
BioGRID
28724758
details
SHC4_HUMAN
NTRK2_HUMAN
BioGRID
28213521
details
SHC4_HUMAN
NTRK1_HUMAN
BioGRID
28213521
details
SHC4_HUMAN
PTN11_HUMAN
BioGRID
28213521
details
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