Entity Details

Primary name C1TM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ6UB35
EntryNameC1TM_HUMAN
FullNameMonofunctional C1-tetrahydrofolate synthase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length978
SequenceStatuscomplete
DateCreated2008-07-01
DateModified2021-06-02

Ontological Relatives

GenesMTHFD1L

GO terms

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GOName
GO:0001843 neural tube closure
GO:0004329 formate-tetrahydrofolate ligase activity
GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006760 folic acid-containing compound metabolic process
GO:0009257 10-formyltetrahydrofolate biosynthetic process
GO:0015942 formate metabolic process
GO:0016020 membrane
GO:0035999 tetrahydrofolate interconversion
GO:0042803 protein homodimerization activity
GO:0046655 folic acid metabolic process
GO:0048702 embryonic neurocranium morphogenesis
GO:0048703 embryonic viscerocranium morphogenesis

Subcellular Location

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Subcellular Location
Mitochondrion

Domains

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DomainNameCategoryType
IPR000559 Formate-tetrahydrofolate ligase, FTHFSFamilyFamily
IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolaseFamilyFamily
IPR020628 Formate-tetrahydrofolate ligase, FTHFS, conserved siteSiteConserved site
IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domainDomainDomain
IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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