Entity Details

Primary name NLRC3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ7RTR2
EntryNameNLRC3_HUMAN
FullNameNLR family CARD domain-containing protein 3
TaxID9606
Evidenceevidence at protein level
Length1065
SequenceStatuscomplete
DateCreated2007-07-24
DateModified2021-06-02

Ontological Relatives

GenesNLRC3

GO terms

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GOName
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032687 negative regulation of interferon-alpha production
GO:0032688 negative regulation of interferon-beta production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0034451 centriolar satellite
GO:0035556 intracellular signal transduction
GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding
GO:0042110 T cell activation
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043231 intracellular membrane-bounded organelle
GO:0045824 negative regulation of innate immune response
GO:0048147 negative regulation of fibroblast proliferation
GO:0048471 perinuclear region of cytoplasm
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050728 negative regulation of inflammatory response
GO:1900016 negative regulation of cytokine production involved in inflammatory response
GO:1900226 negative regulation of NLRP3 inflammasome complex assembly
GO:1901223 negative regulation of NIK/NF-kappaB signaling

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001611 Leucine-rich repeatRepeatRepeat
IPR007111 NACHT nucleoside triphosphataseDomainDomain
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR041075 NOD2, winged helix domainDomainDomain
IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2DomainDomain

Diseases

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Interactions

3 interactions