Entity Details

Primary name TLK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ86UE8
EntryNameTLK2_HUMAN
FullNameSerine/threonine-protein kinase tousled-like 2
TaxID9606
Evidenceevidence at protein level
Length772
SequenceStatuscomplete
DateCreated2003-08-22
DateModified2021-06-02

Ontological Relatives

GenesTLK2

GO terms

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GOName
GO:0001672 regulation of chromatin assembly or disassembly
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005882 intermediate filament
GO:0006325 chromatin organization
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0007059 chromosome segregation
GO:0010507 negative regulation of autophagy
GO:0018105 peptidyl-serine phosphorylation
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0035556 intracellular signal transduction
GO:0042802 identical protein binding
GO:0048471 perinuclear region of cytoplasm
GO:0071480 cellular response to gamma radiation
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR027086 Serine/threonine-protein kinase TOUSLED-like 2FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

26 interactions

InteractorPartnerSourcesPublicationsLink
TLK2_HUMANASF1B_HUMANBioGRID, HPRD, IntAct, MINT11470414 17353931 17940067 20016786 24981860 28514442 details
TLK2_HUMANIRF4_HUMANBioGRID, IntAct21903422 details
TLK2_HUMANIRF7_HUMANBioGRID, IntAct21903422 details
TLK2_HUMANASF1A_HUMANBioGRID, HPRD, IntAct, MINT11470414 20016786 24981860 26496610 28514442 34079125 details
TLK2_HUMANPAX6_HUMANBioGRID, IntAct32296183 details
TLK2_HUMANTLK2_HUMANBioGRID, HPRD, IntAct10523312 32296183 details
TLK2_HUMANCEP70_HUMANBioGRID, IntAct32296183 details
TLK2_HUMANGMCL1_HUMANBioGRID, IntAct32296183 details
TLK2_HUMANFRMD6_HUMANBioGRID, IntAct32296183 details
TLK2_HUMANPAX5_HUMANBioGRID, IntAct32296183 details
TLK2_HUMANDMAP1_HUMANBioGRID, IntAct32296183 details
TLK2_HUMANFEZ1_HUMANBioGRID, HPRD16484223 details
TLK2_HUMANFEZ2_HUMANBioGRID16484223 details
TLK2_HUMANAURKA_HUMANBioGRID17940067 details
TLK2_HUMANUBC9_HUMANBioGRID32296183 details
TLK2_HUMANDYL1_HUMANBioGRID, IntAct26496610 27173435 unassigned1312 details
TLK2_HUMANDYL2_HUMANBioGRID, IntAct27173435 unassigned1312 details
TLK2_HUMANIFFO1_HUMANBioGRID, IntAct27173435 unassigned1312 details
TLK2_HUMANCOBL1_HUMANBioGRID, IntAct27173435 unassigned1312 details
TLK2_HUMANAMOL1_HUMANBioGRID, IntAct27173435 unassigned1312 details
TLK2_HUMANCDAC1_HUMANBioGRID, IntAct27173435 unassigned1312 details
TLK2_HUMANSCML1_HUMANBioGRID, IntAct27173435 unassigned1312 details
TLK2_HUMANTLK1_HUMANBioGRID, HPRD, IntAct10523312 28514442 details
TLK2_HUMANTULP3_HUMANBioGRID33187986 details
TLK2_HUMAN1433Z_HUMANHPRD10455159 details
TLK2_HUMANMBP_HUMANHPRD10523312 details