Entity Details

Primary name PRGC2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ86YN6
EntryNamePRGC2_HUMAN
FullNamePeroxisome proliferator-activated receptor gamma coactivator 1-beta
TaxID9606
Evidenceevidence at protein level
Length1023
SequenceStatuscomplete
DateCreated2006-06-13
DateModified2021-06-02

Ontological Relatives

GenesPPARGC1B

GO terms

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GOName
GO:0001503 ossification
GO:0003712 transcription coregulator activity
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006390 mitochondrial transcription
GO:0007015 actin filament organization
GO:0008134 transcription factor binding
GO:0010694 positive regulation of alkaline phosphatase activity
GO:0016592 mediator complex
GO:0030331 estrogen receptor binding
GO:0030374 nuclear receptor coactivator activity
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0034614 cellular response to reactive oxygen species
GO:0042327 positive regulation of phosphorylation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045780 positive regulation of bone resorption
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050682 AF-2 domain binding
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051384 response to glucocorticoid
GO:0051591 response to cAMP
GO:0060346 bone trabecula formation
GO:0120162 positive regulation of cold-induced thermogenesis

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000504 RNA recognition motif domainDomainDomain
IPR012677 Nucleotide-binding alpha-beta plait domain superfamilyFamilyHomologous superfamily
IPR034177 PPARGC1B, RNA recognition motifDomainDomain
IPR034605 PGC-1FamilyFamily
IPR034621 Peroxisome proliferator-activated receptor gamma coactivator 1-betaFamilyFamily
IPR035979 RNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01118 AmiodaroneDrugbanksmall molecule