Entity Details

Primary name UBR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8IWV8
EntryNameUBR2_HUMAN
FullNameE3 ubiquitin-protein ligase UBR2
TaxID9606
Evidenceevidence at protein level
Length1755
SequenceStatuscomplete
DateCreated2005-08-16
DateModified2021-06-02

Ontological Relatives

GenesUBR2

GO terms

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GOName
GO:0000151 ubiquitin ligase complex
GO:0000209 protein polyubiquitination
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006342 chromatin silencing
GO:0007131 reciprocal meiotic recombination
GO:0007140 male meiotic nuclear division
GO:0007141 male meiosis I
GO:0007283 spermatogenesis
GO:0008270 zinc ion binding
GO:0010529 negative regulation of transposition
GO:0016567 protein ubiquitination
GO:0032007 negative regulation of TOR signaling
GO:0033522 histone H2A ubiquitination
GO:0061630 ubiquitin protein ligase activity
GO:0070728 leucine binding
GO:0071233 cellular response to leucine
GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR003126 Zinc finger, UBR-typeDomainDomain
IPR003769 Adaptor protein ClpS, coreDomainDomain
IPR014719 Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-likeFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR039164 E3 ubiquitin-protein ligase UBR1-likeFamilyFamily
IPR044046 E3 ubiquitin-protein ligase UBR-like, C-terminalDomainDomain

Diseases

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