Entity Details

Primary name SGK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00141
EntryNameSGK1_HUMAN
FullNameSerine/threonine-protein kinase Sgk1
TaxID9606
Evidenceevidence at protein level
Length431
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesSGK1

GO terms

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GOName
GO:0001558 regulation of cell growth
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0005246 calcium channel regulator activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006814 sodium ion transport
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007616 long-term memory
GO:0008217 regulation of blood pressure
GO:0015459 potassium channel regulator activity
GO:0016607 nuclear speck
GO:0017080 sodium channel regulator activity
GO:0017081 chloride channel regulator activity
GO:0018105 peptidyl-serine phosphorylation
GO:0030334 regulation of cell migration
GO:0032411 positive regulation of transporter activity
GO:0034220 ion transmembrane transport
GO:0035556 intracellular signal transduction
GO:0042127 regulation of cell population proliferation
GO:0042981 regulation of apoptotic process
GO:0048812 neuron projection morphogenesis
GO:0050790 regulation of catalytic activity
GO:0051090 regulation of DNA-binding transcription factor activity
GO:0060453 regulation of gastric acid secretion
GO:0070294 renal sodium ion absorption
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1904045 cellular response to aldosterone

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Endoplasmic reticulum membrane
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR017892 Protein kinase, C-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB03247 Flavin mononucleotideDrugbanksmall molecule
DB07837 [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acidDrugbanksmall molecule
DB08191 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acidDrugbanksmall molecule

Interactions

90 interactions

InteractorPartnerSourcesPublicationsLink
SGK1_HUMANCREB1_HUMANHPRD, MINT15733869 details
SGK1_HUMANTAU_HUMANBioGRID, MINT15650334 16982696 17512525 details
SGK1_HUMANPDPK1_HUMANBioGRID, HPRD, IntAct10191262 10357815 12387817 17314099 17916563 details
SGK1_HUMANMAGA1_HUMANBioGRID, IntAct20368287 details
SGK1_HUMANPRAF1_HUMANBioGRID, IntAct21988832 details
SGK1_HUMANT184C_HUMANBioGRID, IntAct21988832 details
SGK1_HUMANGA45G_HUMANBioGRID, IntAct21988832 details
SGK1_HUMANNEMO_HUMANBioGRID, IntAct20098747 details
SGK1_HUMANCETN3_HUMANBioGRID, IntAct32296183 details
SGK1_HUMANMAL2_HUMANBioGRID, IntAct32296183 details
SGK1_HUMANNDRG4_HUMANBioGRID, IntAct32296183 details
SGK1_HUMANMTOR_HUMANBioGRID, IntAct18570873 27451907 details
SGK1_HUMANTSC2_HUMANIntAct27451907 details
SGK1_HUMANFANCA_HUMANBioGRID14499622 details
SGK1_HUMANNEDD4_HUMANBioGRID, HPRD11696533 12729930 19953087 20730100 details
SGK1_HUMANIMA1_HUMANBioGRID, HPRD12631736 details
SGK1_HUMANMK07_HUMANBioGRID, HPRD11254654 details
SGK1_HUMANNHRF2_HUMANBioGRID, HPRD11751930 12387817 details
SGK1_HUMANCHSP1_HUMANBioGRID15910284 details
SGK1_HUMANPK3CA_HUMANBioGRID10357815 details
SGK1_HUMANPP2AA_HUMANBioGRID10357815 details
SGK1_HUMANAF9_HUMANBioGRID17332896 details
SGK1_HUMANPDK1_HUMANBioGRID17314099 details
SGK1_HUMANRICTR_HUMANBioGRID20832730 details
SGK1_HUMANNED4L_HUMANBioGRID, HPRD11742982 12729930 12911626 16006511 16716084 19917253 20525693 20730100 23589291 details
SGK1_HUMANWNK4_HUMANBioGRID20525693 details
SGK1_HUMANUBC_HUMANBioGRID23314748 details
SGK1_HUMANCDN1B_HUMANBioGRID18570873 details
SGK1_HUMANNDRG1_HUMANBioGRID19402821 details
SGK1_HUMANSGK1_HUMANBioGRID25384981 details
SGK1_HUMANPIN1_HUMANBioGRID25667458 details
SGK1_HUMANLPP60_HUMANBioGRID21063096 details
SGK1_HUMANSIN1_HUMANBioGRID28264193 details
SGK1_HUMANMOB1A_HUMANIntAct17353931 details
SGK1_HUMANEIF3I_HUMANIntAct17353931 details
SGK1_HUMANRS3A_HUMANIntAct17353931 details
SGK1_HUMANPIP_HUMANIntAct17353931 details
SGK1_HUMANHNRPL_HUMANIntAct17353931 details
SGK1_HUMANPSA6_HUMANIntAct17353931 details
SGK1_HUMANFSCN1_HUMANIntAct17353931 details
SGK1_HUMANPAL4D_HUMANIntAct17353931 details
SGK1_HUMANMYH1_HUMANIntAct17353931 details
SGK1_HUMANG3P_HUMANIntAct17353931 details
SGK1_HUMANFA98B_HUMANIntAct17353931 details
SGK1_HUMANPABP1_HUMANIntAct17353931 details
SGK1_HUMANDDX6_HUMANIntAct17353931 details
SGK1_HUMANGDIB_HUMANIntAct17353931 details
SGK1_HUMANHYOU1_HUMANIntAct17353931 details
SGK1_HUMANEIF3F_HUMANIntAct17353931 details
SGK1_HUMANPUR6_HUMANIntAct17353931 details
SGK1_HUMANIPO4_HUMANIntAct17353931 details
SGK1_HUMANHNRPM_HUMANIntAct17353931 details
SGK1_HUMANSYVC_HUMANIntAct17353931 details
SGK1_HUMANOLA1_HUMANIntAct17353931 details
SGK1_HUMANCBR3_HUMANIntAct17353931 details
SGK1_HUMANPUR4_HUMANIntAct17353931 details
SGK1_HUMANPSMD6_HUMANIntAct17353931 details
SGK1_HUMANSF3B2_HUMANIntAct17353931 details
SGK1_HUMANATPD_HUMANIntAct17353931 details
SGK1_HUMANLETM1_HUMANIntAct17353931 details
SGK1_HUMANCISY_HUMANIntAct17353931 details
SGK1_HUMANNASP_HUMANIntAct17353931 details
SGK1_HUMANRL3_HUMANIntAct17353931 details
SGK1_HUMANEZRI_HUMANIntAct17353931 details
SGK1_HUMANGANAB_HUMANIntAct17353931 details
SGK1_HUMANHS90B_HUMANIntAct22939624 details
SGK1_HUMANKKCC2_HUMANBioGRID12628440 details
SGK1_HUMANSYVN1_HUMANBioGRID20947508 details
SGK1_HUMANCHIP_HUMANBioGRID16895519 20947508 details
SGK1_HUMANT22D3_HUMANBioGRID19380724 20947508 details
SGK1_HUMANRAF1_HUMANBioGRID19380724 20947508 details
SGK1_HUMANCOMD1_HUMANBioGRID20237237 details
SGK1_HUMANSCNNB_HUMANBioGRID20237237 details
SGK1_HUMANHSP74_HUMANBioGRID16895519 details
SGK1_HUMANWNK1_HUMANBioGRID16006511 20525693 details
SGK1_HUMANWNK2_HUMANBioGRID20525693 details
SGK1_HUMANHS90A_HUMANBioGRID22939624 details
SGK1_HUMAN1433Z_HUMANBioGRID15650334 details
SGK1_HUMAN1433T_HUMANBioGRID15650334 details
SGK1_HUMANRPTOR_HUMANBioGRID18570873 details
SGK1_HUMANAKTS1_HUMANBioGRID18570873 details
SGK1_HUMANEAA1_HUMANHPRD12911626 details
SGK1_HUMANFOXO3_HUMANHPRD11154281 details
SGK1_HUMANNEK6_HUMANHPRD10191262 12023960 details
SGK1_HUMANKKCC1_HUMANHPRD12628440 details
SGK1_HUMANPDK2_HUMANHPRD10191262 details
SGK1_HUMANKCNJ1_HUMANHPRD12684516 details
SGK1_HUMANGSK3B_HUMANHPRD16543730 details
SGK1_HUMANGSK3A_HUMANHPRD16543730 details
SGK1_HUMANBRAF_HUMANHPRD10869359 11410590 details