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Entity Details
Primary name
HACE1_HUMAN
Entity type
UniProt
Source
Source Link
Details
Accession
Q8IYU2
EntryName
HACE1_HUMAN
FullName
E3 ubiquitin-protein ligase HACE1
TaxID
9606
Evidence
evidence at protein level
Length
909
SequenceStatus
complete
DateCreated
2007-03-20
DateModified
2021-06-02
Ontological Relatives
Genes
HACE1
GO terms
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GO
Name
GO:0000139
Golgi membrane
GO:0000209
protein polyubiquitination
GO:0004842
ubiquitin-protein transferase activity
GO:0005634
nucleus
GO:0005737
cytoplasm
GO:0005783
endoplasmic reticulum
GO:0006511
ubiquitin-dependent protein catabolic process
GO:0007030
Golgi organization
GO:0007049
cell cycle
GO:0016567
protein ubiquitination
GO:0016601
Rac protein signal transduction
GO:0016604
nuclear body
GO:0030334
regulation of cell migration
GO:0031267
small GTPase binding
GO:0032580
Golgi cisterna membrane
GO:0043161
proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045732
positive regulation of protein catabolic process
GO:0061025
membrane fusion
GO:0061630
ubiquitin protein ligase activity
GO:0070936
protein K48-linked ubiquitination
Subcellular Location
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Subcellular Location
Cytoplasm
Endoplasmic reticulum
Golgi apparatus
Domains
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Domain
Name
Category
Type
IPR000569
HECT domain
Domain
Domain
IPR002110
Ankyrin repeat
Repeat
Repeat
IPR020683
Ankyrin repeat-containing domain
Domain
Domain
IPR035983
HECT, E3 ligase catalytic domain
Family
Homologous superfamily
IPR036770
Ankyrin repeat-containing domain superfamily
Family
Homologous superfamily
Diseases
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Drugs
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Interactions
15 interactions
Interactor
Partner
Sources
Publications
Link
HACE1_HUMAN
PLXA2_HUMAN
HPRD, IntAct
12421765
unassigned5
details
HACE1_HUMAN
OPTN_HUMAN
BioGRID, IntAct
25026213
details
HACE1_HUMAN
UB2L3_HUMAN
BioGRID, IntAct
22614015
25026213
26949039
27182664
27404360
29643511
details
HACE1_HUMAN
RAB4A_HUMAN
BioGRID, IntAct
21988917
32296183
details
HACE1_HUMAN
RAC1_HUMAN
BioGRID
22036506
22614015
23864022
26343856
28317937
29362425
30659265
details
HACE1_HUMAN
HACE1_HUMAN
BioGRID
26949039
29362425
details
HACE1_HUMAN
SNTG2_HUMAN
BioGRID
27404360
details
HACE1_HUMAN
UB2D2_HUMAN
BioGRID
29643511
details
HACE1_HUMAN
PAK1_HUMAN
BioGRID
29362425
details
HACE1_HUMAN
CASR_HUMAN
BioGRID
30659265
details
HACE1_HUMAN
RARG_HUMAN
BioGRID
19350571
details
HACE1_HUMAN
RARB_HUMAN
BioGRID
19350571
details
HACE1_HUMAN
RARA_HUMAN
BioGRID
19350571
details
HACE1_HUMAN
NOXA1_HUMAN
BioGRID
23864022
details
HACE1_HUMAN
YBOX1_HUMAN
BioGRID
26343856
details
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