Entity Details

Primary name PLK4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00444
EntryNamePLK4_HUMAN
FullNameSerine/threonine-protein kinase PLK4
TaxID9606
Evidenceevidence at protein level
Length970
SequenceStatuscomplete
DateCreated2004-08-16
DateModified2021-06-02

Ontological Relatives

GenesPLK4

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0000922 spindle pole
GO:0001741 XY body
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005814 centriole
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0007099 centriole replication
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0032154 cleavage furrow
GO:0032465 regulation of cytokinesis
GO:0042802 identical protein binding
GO:0046601 positive regulation of centriole replication
GO:0060271 cilium assembly
GO:0060707 trophoblast giant cell differentiation
GO:0097711 ciliary basal body-plasma membrane docking
GO:0098535 de novo centriole assembly involved in multi-ciliated epithelial cell differentiation
GO:0098536 deuterosome
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cleavage furrow
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000959 POLO box domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR033696 Plk4, C-terminal polo-box domainDomainDomain
IPR033698 Plk4, second cryptic polo-box domainDomainDomain
IPR033699 Plk4, first cryptic polo-box domainDomainDomain
IPR033700 Serine/threonine-protein kinase Plk4FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
PLK4_HUMAN1433S_HUMANBioGRID, HPRD, IntAct16189514 details
PLK4_HUMANTET5C_HUMANBioGRID, HPRD, IntAct16189514 details
PLK4_HUMANMTUS2_HUMANBioGRID, HPRD, IntAct16189514 details
PLK4_HUMANPLK4_HUMANBioGRID, DIP, HPRD, IntAct16189514 24997597 25416956 27107012 details
PLK4_HUMANCENPJ_HUMANMINT20531387 details
PLK4_HUMANTX1B3_HUMANBioGRID, IntAct21988832 details
PLK4_HUMANCHD3_HUMANBioGRID, MINT21900206 details
PLK4_HUMANARRC_HUMANBioGRID, IntAct25416956 details
PLK4_HUMANELOA1_HUMANBioGRID, IntAct25416956 32296183 details
PLK4_HUMANCA109_HUMANBioGRID, IntAct25416956 details
PLK4_HUMANCE152_HUMANBioGRID, DIP, IntAct, UniProt20852615 21059844 24613305 24997597 26188084 26496610 26638075 details
PLK4_HUMANFBW1A_HUMANBioGRID, DIP, IntAct20516151 25503564 26871637 details
PLK4_HUMANCEP76_HUMANIntAct27107012 details
PLK4_HUMANMD1L1_HUMANIntAct27107012 details
PLK4_HUMANDRC4_HUMANBioGRID, IntAct32296183 details
PLK4_HUMANTET5B_HUMANBioGRID, IntAct32296183 details
PLK4_HUMANOSBL3_HUMANBioGRID, IntAct32296183 details
PLK4_HUMANTRI54_HUMANBioGRID, IntAct32296183 details
PLK4_HUMANZBT39_HUMANBioGRID, IntAct32296183 details
PLK4_HUMANTFP11_HUMANBioGRID, IntAct32296183 details
PLK4_HUMANSPAG5_HUMANBioGRID, IntAct32296183 details
PLK4_HUMANDJB13_HUMANBioGRID, IntAct32296183 details
PLK4_HUMANECT2_HUMANDIP20348415 details
PLK4_HUMANCE192_HUMANBioGRID, DIP, UniProt24613305 24997597 26188084 details
PLK4_HUMANSTIL_HUMANBioGRID, UniProt24613305 26188084 details
PLK4_HUMANPDIA1_HUMANIntAct32814053 details
PLK4_HUMANPRD16_HUMANBioGRID32296183 details
PLK4_HUMANCYLD_HUMANBioGRID31762063 details
PLK4_HUMANTEC_HUMANHPRD11489907 details
PLK4_HUMANFBXW5_HUMANBioGRID21725316 details
PLK4_HUMANMIB1_HUMANBioGRID25795303 details
PLK4_HUMANSPAT2_HUMANBioGRID31762063 details
PLK4_HUMANNEK7_HUMANBioGRID31762063 details
PLK4_HUMANSMAD4_HUMANHPRD15761153 details
PLK4_HUMANTGFR1_HUMANHPRD15761153 details