Entity Details

Primary name AGRIN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00468
EntryNameAGRIN_HUMAN
FullNameAgrin
TaxID9606
Evidenceevidence at protein level
Length2068
SequenceStatuscomplete
DateCreated2004-10-25
DateModified2021-06-02

Ontological Relatives

GenesAGRN

GO terms

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GOName
GO:0001523 retinoid metabolic process
GO:0002162 dystroglycan binding
GO:0005200 structural constituent of cytoskeleton
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0006024 glycosaminoglycan biosynthetic process
GO:0006027 glycosaminoglycan catabolic process
GO:0007165 signal transduction
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway
GO:0007528 neuromuscular junction development
GO:0009887 animal organ morphogenesis
GO:0009888 tissue development
GO:0016021 integral component of membrane
GO:0030198 extracellular matrix organization
GO:0033691 sialic acid binding
GO:0035374 chondroitin sulfate binding
GO:0043113 receptor clustering
GO:0043202 lysosomal lumen
GO:0043236 laminin binding
GO:0043395 heparan sulfate proteoglycan binding
GO:0043547 positive regulation of GTPase activity
GO:0045162 clustering of voltage-gated sodium channels
GO:0045202 synapse
GO:0045887 positive regulation of synaptic assembly at neuromuscular junction
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050808 synapse organization
GO:0051491 positive regulation of filopodium assembly
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR000082 SEA domainDomainDomain
IPR000742 EGF-like domainDomainDomain
IPR001791 Laminin G domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR002049 Laminin EGF domainDomainDomain
IPR002350 Kazal domainDomainDomain
IPR003645 Follistatin-like, N-terminalDomainDomain
IPR003884 Factor I / membrane attack complexDomainDomain
IPR004850 NtA (N-terminal agrin) domainDomainDomain
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-foldFamilyHomologous superfamily
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR036058 Kazal domain superfamilyFamilyHomologous superfamily
IPR036364 SEA domain superfamilyFamilyHomologous superfamily

Diseases

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