Entity Details

Primary name KDM2B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8NHM5
EntryNameKDM2B_HUMAN
FullNameLysine-specific demethylase 2B
TaxID9606
Evidenceevidence at protein level
Length1336
SequenceStatuscomplete
DateCreated2004-08-16
DateModified2021-06-02

Ontological Relatives

GenesKDM2B

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003712 transcription coregulator activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006482 protein demethylation
GO:0007283 spermatogenesis
GO:0008270 zinc ion binding
GO:0019843 rRNA binding
GO:0021555 midbrain-hindbrain boundary morphogenesis
GO:0021592 fourth ventricle development
GO:0021670 lateral ventricle development
GO:0021678 third ventricle development
GO:0021993 initiation of neural tube closure
GO:0030307 positive regulation of cell growth
GO:0030900 forebrain development
GO:0030901 midbrain development
GO:0030902 hindbrain development
GO:0032452 histone demethylase activity
GO:0035518 histone H2A monoubiquitination
GO:0043524 negative regulation of neuron apoptotic process
GO:0045322 unmethylated CpG binding
GO:0048596 embryonic camera-type eye morphogenesis
GO:0051864 histone demethylase activity (H3-K36 specific)
GO:0070544 histone H3-K36 demethylation
GO:1902459 positive regulation of stem cell population maintenance
GO:2000178 negative regulation of neural precursor cell proliferation

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR001810 F-box domainDomainDomain
IPR001965 Zinc finger, PHD-typeDomainDomain
IPR002857 Zinc finger, CXXC-typeDomainDomain
IPR003347 JmjC domainDomainDomain
IPR006553 Leucine-rich repeat, cysteine-containing subtypeRepeatRepeat
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR019787 Zinc finger, PHD-fingerDomainDomain
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR041070 Jumonji, helical domainDomainDomain
IPR041667 Cupin-like domain 8DomainDomain

Diseases

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Interactions

24 interactions

InteractorPartnerSourcesPublicationsLink
KDM2B_HUMANSKP1_HUMANBioGRID, IntAct, MINT, UniProt16943429 17463251 17704768 24981860 25533466 26725323 27705803 28614300 30033217 30596474 details
KDM2B_HUMANLZTR1_HUMANBioGRID, IntAct20211142 details
KDM2B_HUMANCEBPE_HUMANBioGRID, IntAct20211142 details
KDM2B_HUMANH31_HUMANBioGRID17994099 22825849 31531877 details
KDM2B_HUMANKDM2B_HUMANBioGRID22825849 details
KDM2B_HUMANUB2D1_HUMANBioGRID22825849 details
KDM2B_HUMANFOS_HUMANBioGRID26725323 details
KDM2B_HUMANKAT5_HUMANBioGRID31218831 details
KDM2B_HUMANCBP_HUMANBioGRID31531877 details
KDM2B_HUMANPCGF1_HUMANBioGRID, IntAct, MINT, UniProt16943429 22325352 23395003 24981860 25533466 26687479 27505670 27705803 29502955 29985131 details
KDM2B_HUMANBCOR_HUMANBioGRID, IntAct, MINT, UniProt16943429 24981860 25533466 26496610 26687479 27505670 29502955 details
KDM2B_HUMANRING2_HUMANBioGRID, IntAct, MINT22325352 23395003 24457600 24981860 25533466 26496610 27705803 29985131 details
KDM2B_HUMANRYBP_HUMANBioGRID, IntAct, MINT22325352 23395003 24981860 26186194 27705803 28514442 details
KDM2B_HUMANH2AX_HUMANBioGRID, MINT24981860 29985131 details
KDM2B_HUMANEZH2_HUMANBioGRID19202064 details
KDM2B_HUMANJUN_HUMANBioGRID17704768 details
KDM2B_HUMANCUL1_HUMANBioGRID17704768 26725323 details
KDM2B_HUMANSIN3A_HUMANBioGRID17704768 details
KDM2B_HUMANRBX1_HUMANBioGRID26725323 details
KDM2B_HUMANXRCC5_HUMANBioGRID29985131 details
KDM2B_HUMANSSX1_HUMANBioGRID29502955 details
KDM2B_HUMANBCL6_HUMANBioGRID29352142 details
KDM2B_HUMANSMG7_HUMANBioGRID29395067 details
KDM2B_HUMANSPT5H_HUMANBioGRID29395067 details