Entity Details

Primary name DDX3X_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00571
EntryNameDDX3X_HUMAN
FullNameATP-dependent RNA helicase DDX3X
TaxID9606
Evidenceevidence at protein level
Length662
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesDDX3X

GO terms

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GOName
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0003729 mRNA binding
GO:0003924 GTPase activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006413 translational initiation
GO:0007059 chromosome segregation
GO:0007276 gamete generation
GO:0008134 transcription factor binding
GO:0008143 poly(A) binding
GO:0008190 eukaryotic initiation factor 4E binding
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0009615 response to virus
GO:0010494 cytoplasmic stress granule
GO:0010501 RNA secondary structure unwinding
GO:0010628 positive regulation of gene expression
GO:0016032 viral process
GO:0016055 Wnt signaling pathway
GO:0016887 ATP hydrolysis activity
GO:0017111 nucleoside-triphosphatase activity
GO:0017148 negative regulation of translation
GO:0030027 lamellipodium
GO:0030154 cell differentiation
GO:0030307 positive regulation of cell growth
GO:0030308 negative regulation of cell growth
GO:0031252 cell leading edge
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031369 translation initiation factor binding
GO:0031954 positive regulation of protein autophosphorylation
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0033592 RNA strand annealing activity
GO:0034063 stress granule assembly
GO:0034157 positive regulation of toll-like receptor 7 signaling pathway
GO:0034161 positive regulation of toll-like receptor 8 signaling pathway
GO:0034774 secretory granule lumen
GO:0035556 intracellular signal transduction
GO:0035613 RNA stem-loop binding
GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress
GO:0042256 mature ribosome assembly
GO:0043015 gamma-tubulin binding
GO:0043024 ribosomal small subunit binding
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043186 P granule
GO:0043273 CTPase activity
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043312 neutrophil degranulation
GO:0043539 protein serine/threonine kinase activator activity
GO:0045070 positive regulation of viral genome replication
GO:0045087 innate immune response
GO:0045296 cadherin binding
GO:0045727 positive regulation of translation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045948 positive regulation of translational initiation
GO:0048027 mRNA 5'-UTR binding
GO:0055088 lipid homeostasis
GO:0070062 extracellular exosome
GO:0071243 cellular response to arsenic-containing substance
GO:0071470 cellular response to osmotic stress
GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0072559 NLRP3 inflammasome complex
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0097193 intrinsic apoptotic signaling pathway
GO:0098586 cellular response to virus
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1900227 positive regulation of NLRP3 inflammasome complex assembly
GO:1901223 negative regulation of NIK/NF-kappaB signaling
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1901985 positive regulation of protein acetylation
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902523 positive regulation of protein K63-linked ubiquitination
GO:1903608 protein localization to cytoplasmic stress granule
GO:1904813 ficolin-1-rich granule lumen
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Inflammasome
Nucleus

Domains

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DomainNameCategoryType
IPR000629 ATP-dependent RNA helicase DEAD-box, conserved siteSiteConserved site
IPR001650 Helicase, C-terminalDomainDomain
IPR011545 DEAD/DEAH box helicase domainDomainDomain
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR014014 RNA helicase, DEAD-box type, Q motifDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

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Interactions

99 interactions

InteractorPartnerSourcesPublicationsLink
DDX3X_HUMANZ512B_HUMANBioGRID, MINT15231748 details
DDX3X_HUMANWBP4_HUMANBioGRID, MINT16055720 details
DDX3X_HUMANIKKE_HUMANBioGRID, MINT, UniProt18636090 20657822 27980081 details
DDX3X_HUMANTBK1_HUMANMINT18583960 details
DDX3X_HUMANESR1_HUMANBioGRID, IntAct20308691 20348541 21182205 details
DDX3X_HUMANCSK21_HUMANBioGRID, IntAct22113938 details
DDX3X_HUMANEIF3C_HUMANBioGRID, UniProt18628297 22323517 details
DDX3X_HUMANPABP1_HUMANMINT, UniProt18596238 21883093 22872150 details
DDX3X_HUMANIF2A_HUMANUniProt18596238 22323517 details
DDX3X_HUMANMAVS_HUMANBioGRID, UniProt20127681 27980081 details
DDX3X_HUMANIF4G1_HUMANMINT22872150 details
DDX3X_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
DDX3X_HUMANTFF2_HUMANIntAct32814053 details
DDX3X_HUMANDCNP1_HUMANIntAct32814053 details
DDX3X_HUMANMZT2A_HUMANIntAct32814053 details
DDX3X_HUMANTADBP_HUMANBioGRID, IntAct20020773 32814053 details
DDX3X_HUMANSREK1_HUMANBioGRID, HPRD14559993 details
DDX3X_HUMANSP1_HUMANBioGRID16818630 details
DDX3X_HUMAN1433T_HUMANBioGRID15161933 details
DDX3X_HUMANAPBB1_HUMANBioGRID16055720 details
DDX3X_HUMANNEDD4_HUMANBioGRID16055720 details
DDX3X_HUMANPIN1_HUMANBioGRID16055720 details
DDX3X_HUMANSUMO2_HUMANBioGRID19394292 32786267 details
DDX3X_HUMANSRPK2_HUMANBioGRID26167880 details
DDX3X_HUMANTRAF3_HUMANBioGRID27980081 details
DDX3X_HUMANNR0B2_HUMANBioGRID28128295 details
DDX3X_HUMANHNF4A_HUMANBioGRID28128295 details
DDX3X_HUMANOGT1_HUMANBioGRID32994395 details
DDX3X_HUMANM3K14_HUMANIntAct14743216 details
DDX3X_HUMANRIPK3_HUMANIntAct14743216 details
DDX3X_HUMANTRAF1_HUMANIntAct14743216 details
DDX3X_HUMANFBX33_HUMANMINT16797541 details
DDX3X_HUMANRA51C_HUMANIntAct17353931 details
DDX3X_HUMAN1433Z_HUMANMINT15161933 details
DDX3X_HUMANTOB1_HUMANUniProt18377426 details
DDX3X_HUMANIF4E_HUMANMINT, UniProt18596238 19262567 21883093 22872150 details
DDX3X_HUMANEIF3E_HUMANBioGRID, UniProt18628297 29395067 details
DDX3X_HUMANEIF3B_HUMANBioGRID, UniProt18628297 29395067 details
DDX3X_HUMANNXF1_HUMANUniProt18596238 details
DDX3X_HUMANTIA1_HUMANUniProt18596238 details
DDX3X_HUMANELAV1_HUMANBioGRID, UniProt18596238 19322201 details
DDX3X_HUMANRS3_HUMANBioGRID, UniProt22323517 22863883 details
DDX3X_HUMANDDX58_HUMANUniProt20127681 details
DDX3X_HUMANIFIH1_HUMANUniProt20127681 details
DDX3X_HUMANCND2_HUMANUniProt21730191 details
DDX3X_HUMANIF4A1_HUMANBioGRID, MINT22872150 29395067 details
DDX3X_HUMANIF4B_HUMANBioGRID, MINT22872150 29228324 details
DDX3X_HUMANYBOX1_HUMANHPIDb23986595 24965446 details
DDX3X_HUMANFUS_HUMANBioGRID, UniProt27460707 29884807 details
DDX3X_HUMANTRAF6_HUMANBioGRID17353931 27507811 details
DDX3X_HUMANSRRM2_HUMANBioGRID16159877 details
DDX3X_HUMANTERF2_HUMANBioGRID20811636 details
DDX3X_HUMANPOTE1_HUMANBioGRID20811636 details
DDX3X_HUMANHDAC5_HUMANBioGRID21081666 details
DDX3X_HUMANSMRCD_HUMANBioGRID21549307 details
DDX3X_HUMANTYY1_HUMANBioGRID22210892 details
DDX3X_HUMANTDRD3_HUMANBioGRID18632687 29395067 details
DDX3X_HUMANCALM1_HUMANBioGRID17696464 details
DDX3X_HUMANCALM2_HUMANBioGRID17696464 details
DDX3X_HUMANCALM3_HUMANBioGRID17696464 details
DDX3X_HUMANTHOC4_HUMANBioGRID15998806 details
DDX3X_HUMANHNRPQ_HUMANBioGRID22939629 26344197 29395067 details
DDX3X_HUMANEIF3J_HUMANBioGRID18628297 details
DDX3X_HUMANITA4_HUMANBioGRID22623428 details
DDX3X_HUMANRAC1_HUMANBioGRID19961560 details
DDX3X_HUMANMAEL_HUMANBioGRID24189637 details
DDX3X_HUMANXPO1_HUMANBioGRID, HPRD15507209 26673895 details
DDX3X_HUMANIRF3_HUMANBioGRID27980081 details
DDX3X_HUMANFGF11_HUMANBioGRID28027390 details
DDX3X_HUMANCDK9_HUMANBioGRID26209609 details
DDX3X_HUMANCDC37_HUMANBioGRID16611982 details
DDX3X_HUMANERPG3_HUMANBioGRID26030138 details
DDX3X_HUMANERCC6_HUMANBioGRID26030138 details
DDX3X_HUMANCBP_HUMANBioGRID28128295 details
DDX3X_HUMANEP300_HUMANBioGRID28128295 details
DDX3X_HUMANSOX2_HUMANBioGRID21280222 details
DDX3X_HUMANPPIA_HUMANBioGRID25678563 details
DDX3X_HUMANANM8_HUMANBioGRID18320585 details
DDX3X_HUMANANKH1_HUMANBioGRID29395067 details
DDX3X_HUMANAP2A1_HUMANBioGRID29395067 details
DDX3X_HUMANCNOT3_HUMANBioGRID29395067 details
DDX3X_HUMANCPEB4_HUMANBioGRID29395067 details
DDX3X_HUMANKIF1B_HUMANBioGRID29395067 details
DDX3X_HUMANLS14A_HUMANBioGRID29395067 details
DDX3X_HUMANLS14B_HUMANBioGRID29395067 details
DDX3X_HUMANPABP4_HUMANBioGRID29395067 details
DDX3X_HUMANPATL1_HUMANBioGRID29395067 details
DDX3X_HUMANPUM1_HUMANBioGRID29395067 details
DDX3X_HUMANRTCB_HUMANBioGRID29395067 details
DDX3X_HUMANSEBP2_HUMANBioGRID29395067 details
DDX3X_HUMANTHUM3_HUMANBioGRID29395067 details
DDX3X_HUMANDDX6_HUMANBioGRID29395067 details
DDX3X_HUMANDOCK4_HUMANBioGRID29395067 details
DDX3X_HUMANF120C_HUMANBioGRID29395067 details
DDX3X_HUMANFXR1_HUMANBioGRID29395067 details
DDX3X_HUMANR3HD1_HUMANBioGRID29395067 details
DDX3X_HUMANZN598_HUMANBioGRID29395067 details
DDX3X_HUMANISG15_HUMANBioGRID33024031 details
DDX3X_HUMANNUP62_HUMANHPRD15507209 details