Entity Details

Primary name IRF6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14896
EntryNameIRF6_HUMAN
FullNameInterferon regulatory factor 6
TaxID9606
Evidenceevidence at protein level
Length467
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesIRF6

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002376 immune system process
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008285 negative regulation of cell population proliferation
GO:0030054 cell junction
GO:0030216 keratinocyte differentiation
GO:0043565 sequence-specific DNA binding
GO:0043616 keratinocyte proliferation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048468 cell development
GO:0060021 roof of mouth development
GO:0060173 limb development
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0060644 mammary gland epithelial cell differentiation
GO:0070062 extracellular exosome
GO:1904888 cranial skeletal system development
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001346 Interferon regulatory factor DNA-binding domainDomainDomain
IPR008984 SMAD/FHA domain superfamilyFamilyHomologous superfamily
IPR017855 SMAD-like domain superfamilyFamilyHomologous superfamily
IPR019471 Interferon regulatory factor-3DomainDomain
IPR019817 Interferon regulatory factor, conserved siteSiteConserved site
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
IRF6_HUMANIRF8_HUMANBioGRID, IntAct21903422 details
IRF6_HUMANTLX2_HUMANBioGRID, IntAct20211142 details
IRF6_HUMANRFX3_HUMANBioGRID, IntAct20211142 details
IRF6_HUMANZBTB3_HUMANIntAct20211142 details