Entity Details

Primary name NED4L_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96PU5
EntryNameNED4L_HUMAN
FullNameE3 ubiquitin-protein ligase NEDD4-like
TaxID9606
Evidenceevidence at protein level
Length975
SequenceStatuscomplete
DateCreated2005-08-30
DateModified2021-06-02

Ontological Relatives

GenesNEDD4L

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000209 protein polyubiquitination
GO:0003254 regulation of membrane depolarization
GO:0004842 ubiquitin-protein transferase activity
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005771 multivesicular body
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006814 sodium ion transport
GO:0006883 cellular sodium ion homeostasis
GO:0007588 excretion
GO:0010038 response to metal ion
GO:0015459 potassium channel regulator activity
GO:0016567 protein ubiquitination
GO:0017080 sodium channel regulator activity
GO:0019058 viral life cycle
GO:0019870 potassium channel inhibitor activity
GO:0019871 sodium channel inhibitor activity
GO:0030104 water homeostasis
GO:0030154 cell differentiation
GO:0031647 regulation of protein stability
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0042176 regulation of protein catabolic process
GO:0042391 regulation of membrane potential
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044325 transmembrane transporter binding
GO:0045732 positive regulation of protein catabolic process
GO:0045807 positive regulation of endocytosis
GO:0048814 regulation of dendrite morphogenesis
GO:0060306 regulation of membrane repolarization
GO:0061630 ubiquitin protein ligase activity
GO:0070062 extracellular exosome
GO:0070936 protein K48-linked ubiquitination
GO:0086005 ventricular cardiac muscle cell action potential
GO:1901016 regulation of potassium ion transmembrane transporter activity
GO:1901017 negative regulation of potassium ion transmembrane transporter activity
GO:1901380 negative regulation of potassium ion transmembrane transport
GO:1902306 negative regulation of sodium ion transmembrane transport
GO:1903861 positive regulation of dendrite extension
GO:2000009 negative regulation of protein localization to cell surface
GO:2000650 negative regulation of sodium ion transmembrane transporter activity
GO:2001288 positive regulation of caveolin-mediated endocytosis

Subcellular Location

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Subcellular Location
Cytoplasm
Endosome
Golgi apparatus

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000569 HECT domainDomainDomain
IPR001202 WW domainDomainDomain
IPR024928 E3 ubiquitin-protein ligase, SMURF1 typeFamilyFamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR035983 HECT, E3 ligase catalytic domainFamilyHomologous superfamily
IPR036020 WW domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

188 interactions

InteractorPartnerSourcesPublicationsLink
NED4L_HUMANRNF11_HUMANBioGRID, HPRD, MINT15231748 28292929 details
NED4L_HUMANSMAD2_HUMANBioGRID, MINT15231748 19917253 26555259 details
NED4L_HUMANLAPM5_HUMANBioGRID, HPRD, MINT15231748 details
NED4L_HUMANGDIR1_HUMANBioGRID, HPRD, IntAct16169070 details
NED4L_HUMAN1433Z_HUMANBioGRID, MINT15161933 20936779 details
NED4L_HUMANMED28_HUMANBioGRID, MINT16964398 details
NED4L_HUMANUBC_HUMANBioGRID, MINT19343052 20064473 22496338 23644597 25752577 28461335 29964046 details
NED4L_HUMANAMOT_HUMANBioGRID, IntAct, MINT19615732 24981860 25633977 details
NED4L_HUMAN1433G_HUMANBioGRID, IntAct20936779 28514442 details
NED4L_HUMANWNK1_HUMANBioGRID, IntAct20525693 20936779 26241057 details
NED4L_HUMANAATF_HUMANBioGRID, IntAct21988832 details
NED4L_HUMANGORAB_HUMANBioGRID, IntAct21988832 details
NED4L_HUMANRPGF2_HUMANMINT21765395 details
NED4L_HUMANSCNNB_HUMANBioGRID, HPRD, MINT11244092 11802777 12876068 15328345 15814530 16416336 16844684 18322022 18498246 19380724 21765395 details
NED4L_HUMANDAZP2_HUMANBioGRID, IntAct25416956 32296183 details
NED4L_HUMANARRD3_HUMANBioGRID, IntAct23236378 28514442 29416926 32296183 details
NED4L_HUMANSMAD3_HUMANBioGRID, DIP19917253 22921829 24071738 26555259 details
NED4L_HUMANSMAD7_HUMANBioGRID, DIP22773947 22921829 details
NED4L_HUMANGCR_HUMANBioGRID9649342 details
NED4L_HUMANSCNNA_HUMANBioGRID, HPRD11244092 11802777 12876068 14556380 15328345 16416336 16844684 17502380 18322022 18498246 18701608 26651153 details
NED4L_HUMANSCNNG_HUMANBioGRID, HPRD11244092 11802777 12876068 15328345 16416336 16716084 16844684 18322022 18498246 details
NED4L_HUMANNED4L_HUMANBioGRID, HPRD17719543 18498246 18656546 19153599 20542005 21396940 22496338 23695783 25527291 26949039 28972136 30021006 30587574 details
NED4L_HUMANPSMD4_HUMANBioGRID20542005 details
NED4L_HUMANACK1_HUMANBioGRID19144635 23686771 details
NED4L_HUMANKCNB1_HUMANBioGRID19953087 details
NED4L_HUMANMAPK3_HUMANBioGRID19953087 details
NED4L_HUMANCLIC2_HUMANBioGRID19953087 details
NED4L_HUMANFBLN4_HUMANBioGRID19953087 details
NED4L_HUMANHGS_HUMANBioGRID19953087 20675381 details
NED4L_HUMANNFIP2_HUMANBioGRID, HPRD12050153 15252135 19953087 details
NED4L_HUMANM3K3_HUMANBioGRID19953087 details
NED4L_HUMANVDAC2_HUMANBioGRID19953087 details
NED4L_HUMANZDHC3_HUMANBioGRID19953087 details
NED4L_HUMANKCC1D_HUMANBioGRID19953087 details
NED4L_HUMANRBP10_HUMANBioGRID19953087 details
NED4L_HUMANCDK5_HUMANBioGRID19953087 details
NED4L_HUMANABL1_HUMANBioGRID19953087 details
NED4L_HUMANMAGB1_HUMANBioGRID19953087 details
NED4L_HUMANDEMA_HUMANBioGRID19953087 details
NED4L_HUMANAICDA_HUMANBioGRID19953087 details
NED4L_HUMANMARK2_HUMANBioGRID19953087 details
NED4L_HUMANKCAB1_HUMANBioGRID19953087 details
NED4L_HUMANFKBP3_HUMANBioGRID19953087 details
NED4L_HUMANDAPK3_HUMANBioGRID19953087 details
NED4L_HUMANBRAF_HUMANBioGRID19953087 31015455 details
NED4L_HUMANM3K5_HUMANBioGRID19953087 details
NED4L_HUMANDDX54_HUMANBioGRID19953087 details
NED4L_HUMANM3K20_HUMANBioGRID19953087 details
NED4L_HUMANKCAB3_HUMANBioGRID19953087 details
NED4L_HUMANNTRK1_HUMANBioGRID, HPRD16701206 19953087 details
NED4L_HUMANCUED1_HUMANBioGRID19953087 details
NED4L_HUMANKS6B2_HUMANBioGRID19953087 details
NED4L_HUMANABL2_HUMANBioGRID19953087 details
NED4L_HUMANCACB1_HUMANBioGRID19953087 details
NED4L_HUMANTYY1_HUMANBioGRID19953087 details
NED4L_HUMANM3K2_HUMANBioGRID19953087 details
NED4L_HUMANBBX_HUMANBioGRID19953087 details
NED4L_HUMANPRKX_HUMANBioGRID19953087 details
NED4L_HUMANACV1B_HUMANBioGRID19953087 details
NED4L_HUMANADAP2_HUMANBioGRID19953087 details
NED4L_HUMANBMR1A_HUMANBioGRID19953087 details
NED4L_HUMANAKT3_HUMANBioGRID19953087 details
NED4L_HUMANMINK1_HUMANBioGRID19953087 details
NED4L_HUMANAURKC_HUMANBioGRID19953087 details
NED4L_HUMANNSRP1_HUMANBioGRID19953087 details
NED4L_HUMANPYM1_HUMANBioGRID19953087 details
NED4L_HUMANSGK2_HUMANBioGRID19953087 details
NED4L_HUMANUBAC1_HUMANBioGRID19953087 details
NED4L_HUMANRL30_HUMANBioGRID19953087 details
NED4L_HUMANMERTK_HUMANBioGRID19953087 details
NED4L_HUMANSRMS_HUMANBioGRID19953087 details
NED4L_HUMANPEDF_HUMANBioGRID19953087 details
NED4L_HUMANDYRK3_HUMANBioGRID19953087 details
NED4L_HUMANIFRD2_HUMANBioGRID19953087 details
NED4L_HUMANSCD_HUMANBioGRID19953087 details
NED4L_HUMANROBO3_HUMANBioGRID19953087 details
NED4L_HUMANTRI41_HUMANBioGRID19953087 details
NED4L_HUMANTMA16_HUMANBioGRID19953087 details
NED4L_HUMANTAF1B_HUMANBioGRID19953087 details
NED4L_HUMANSPAG8_HUMANBioGRID19953087 details
NED4L_HUMANSTAC_HUMANBioGRID19953087 details
NED4L_HUMANH10_HUMANBioGRID19953087 details
NED4L_HUMANLARGN_HUMANBioGRID19953087 details
NED4L_HUMANKIFC3_HUMANBioGRID19953087 details
NED4L_HUMANRSLAB_HUMANBioGRID19953087 details
NED4L_HUMANTMG1_HUMANBioGRID19953087 details
NED4L_HUMANCDK3_HUMANBioGRID19953087 details
NED4L_HUMANKCAB2_HUMANBioGRID19953087 details
NED4L_HUMANFGF12_HUMANBioGRID19953087 details
NED4L_HUMANRBX2_HUMANBioGRID19953087 details
NED4L_HUMANAPEX2_HUMANBioGRID19953087 details
NED4L_HUMANRM19_HUMANBioGRID19953087 details
NED4L_HUMANTGFI1_HUMANBioGRID19953087 details
NED4L_HUMANTBCD7_HUMANBioGRID19953087 details
NED4L_HUMANNHP2_HUMANBioGRID19953087 details
NED4L_HUMANPP4P2_HUMANBioGRID19953087 details
NED4L_HUMANCP26B_HUMANBioGRID19953087 details
NED4L_HUMANDECR2_HUMANBioGRID19953087 details
NED4L_HUMANSENP2_HUMANBioGRID19953087 details
NED4L_HUMANSIVA_HUMANBioGRID19953087 details
NED4L_HUMANRSLBB_HUMANBioGRID19953087 details
NED4L_HUMANMTAP2_HUMANBioGRID19953087 details
NED4L_HUMANSTK40_HUMANBioGRID19953087 details
NED4L_HUMANTIRR_HUMANBioGRID19953087 details
NED4L_HUMANCG050_HUMANBioGRID19953087 details
NED4L_HUMANTCAL2_HUMANBioGRID19953087 details
NED4L_HUMANZCCHL_HUMANBioGRID19953087 details
NED4L_HUMANMOB3A_HUMANBioGRID19953087 details
NED4L_HUMANTRBP2_HUMANBioGRID19953087 details
NED4L_HUMANPTGR3_HUMANBioGRID19953087 details
NED4L_HUMANWBP2_HUMANBioGRID19953087 27182664 27578003 details
NED4L_HUMANSGK1_HUMANBioGRID, HPRD11742982 12729930 12911626 16006511 16716084 19917253 20525693 20730100 23589291 details
NED4L_HUMANWNK4_HUMANBioGRID20525693 details
NED4L_HUMANIKKB_HUMANBioGRID18981174 details
NED4L_HUMANUB2D2_HUMANBioGRID19953087 20064473 20542005 22496338 23695783 27182664 27932573 28972136 29643511 33282879 details
NED4L_HUMANNPC2_HUMANBioGRID19664597 details
NED4L_HUMANMT2_HUMANBioGRID19664597 details
NED4L_HUMANAT1B1_HUMANBioGRID19664597 details
NED4L_HUMANCYBR1_HUMANBioGRID19664597 details
NED4L_HUMANYLAT1_HUMANBioGRID19664597 details
NED4L_HUMANPBX1_HUMANBioGRID19664597 details
NED4L_HUMANACY3_HUMANBioGRID19664597 details
NED4L_HUMANHAX1_HUMANBioGRID19664597 details
NED4L_HUMANKIF3B_HUMANBioGRID19664597 details
NED4L_HUMANUB2L3_HUMANBioGRID, HPRD18498246 23695783 25527291 25752577 26949039 27182664 29643511 30587574 33282879 8576257 9575161 details
NED4L_HUMANUBE2K_HUMANBioGRID17429078 22496338 details
NED4L_HUMANUB2D1_HUMANBioGRID21396940 24071738 28972136 33282879 9575161 details
NED4L_HUMANUB2E3_HUMANBioGRID22496338 23695783 28972136 details
NED4L_HUMANUB2J2_HUMANBioGRID22496338 details
NED4L_HUMANUB2R1_HUMANBioGRID22496338 details
NED4L_HUMANUB2D3_HUMANBioGRID23644597 23695783 27339899 28972136 30021006 33282879 details
NED4L_HUMANUBE2N_HUMANBioGRID24071738 details
NED4L_HUMANSYUA_HUMANBioGRID24831002 30021006 details
NED4L_HUMANRHOB_HUMANBioGRID26949039 details
NED4L_HUMANULK1_HUMANBioGRID27932573 31959741 details
NED4L_HUMANGRIA1_HUMANBioGRID28212375 details
NED4L_HUMANSCN5A_HUMANBioGRID, HPRD15217910 15548568 28296171 31900993 details
NED4L_HUMANUB2E1_HUMANBioGRID, HPRD28972136 33282879 8576257 details
NED4L_HUMANUB2E2_HUMANBioGRID28972136 details
NED4L_HUMANUB2L6_HUMANBioGRID28972136 details
NED4L_HUMANPK3CA_HUMANBioGRID27339899 details
NED4L_HUMANBEST1_HUMANBioGRID31036321 details
NED4L_HUMANFOXO1_HUMANBioGRID31844113 details
NED4L_HUMANPINK1_HUMANBioGRID32140098 details
NED4L_HUMANTMG4_HUMANBioGRID23873930 details
NED4L_HUMANTMG2_HUMANBioGRID23873930 details
NED4L_HUMANSP1_HUMANBioGRID32724456 details
NED4L_HUMANOGG1_HUMANBioGRID33282879 details
NED4L_HUMAN1433S_HUMANBioGRID, MINT15778465 details
NED4L_HUMANSTIP1_HUMANMINT15778465 details
NED4L_HUMAN1433F_HUMANBioGRID, IntAct, MINT15677482 16716084 28514442 details
NED4L_HUMANFXL15_HUMANBioGRID, MINT21572392 details
NED4L_HUMANLITAF_HUMANBioGRID, IntAct25963657 28514442 details
NED4L_HUMANOCLN_HUMANBioGRID, IntAct20504882 28514442 details
NED4L_HUMANNRAM2_HUMANDIP19706893 details
NED4L_HUMAN1433B_HUMANBioGRID20338996 details
NED4L_HUMANAPBB1_HUMANBioGRID19381069 details
NED4L_HUMANNFIP1_HUMANBioGRID22213801 details
NED4L_HUMANRAF1_HUMANBioGRID19380724 details
NED4L_HUMANT22D3_HUMANBioGRID19380724 details
NED4L_HUMANAMOL1_HUMANBioGRID22558212 33058421 details
NED4L_HUMAN1433T_HUMANBioGRID21900244 23444366 details
NED4L_HUMANKCNH2_HUMANBioGRID22879586 24688054 details
NED4L_HUMANCAV3_HUMANBioGRID22879586 details
NED4L_HUMANKCNQ1_HUMANBioGRID23529131 26405101 32173736 details
NED4L_HUMANSGK3_HUMANBioGRID23589291 details
NED4L_HUMANNOTC1_HUMANBioGRID23886940 details
NED4L_HUMANHCN1_HUMANBioGRID24451387 details
NED4L_HUMANSMAD6_HUMANBioGRID24850914 details
NED4L_HUMANSL9A3_HUMANBioGRID24831004 details
NED4L_HUMANWNK3_HUMANBioGRID24920754 details
NED4L_HUMANPTC1_HUMANBioGRID25092867 details
NED4L_HUMANS22AB_HUMANBioGRID26740304 30453017 details
NED4L_HUMANS22A8_HUMANBioGRID26651153 details
NED4L_HUMANCRYAB_HUMANBioGRID26961874 details
NED4L_HUMANGRB10_HUMANBioGRID27146988 27742835 details
NED4L_HUMANKCNA3_HUMANBioGRID27146988 details
NED4L_HUMANERBB3_HUMANBioGRID27793840 details
NED4L_HUMANFAK2_HUMANBioGRID27793840 details
NED4L_HUMANLPAR1_HUMANBioGRID27448760 details
NED4L_HUMANS22A6_HUMANBioGRID28572241 details
NED4L_HUMANIL2RG_HUMANBioGRID27742835 details
NED4L_HUMANIL4RA_HUMANBioGRID27742835 details
NED4L_HUMANPKHD1_HUMANBioGRID28798345 details
NED4L_HUMANCRTC3_HUMANBioGRID29505301 details
NED4L_HUMANMERL_HUMANBioGRID33058421 details
NED4L_HUMANSTK35_HUMANBioGRID33117809 details
NED4L_HUMANSCAM3_HUMANHPRD19158374 details