Entity Details

Primary name HBEGF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99075
EntryNameHBEGF_HUMAN
FullNameProheparin-binding EGF-like growth factor
TaxID9606
Evidenceevidence at protein level
Length208
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesHBEGF

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0005154 epidermal growth factor receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007517 muscle organ development
GO:0008016 regulation of heart contraction
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0008284 positive regulation of cell population proliferation
GO:0009986 cell surface
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030666 endocytic vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0035313 wound healing, spreading of epidermal cells
GO:0038128 ERBB2 signaling pathway
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051545 negative regulation of elastin biosynthetic process
GO:0051549 positive regulation of keratinocyte migration
GO:0051897 positive regulation of protein kinase B signaling
GO:0060326 cell chemotaxis
GO:0061024 membrane organization
GO:0090303 positive regulation of wound healing
GO:2000145 regulation of cell motility

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR000742 EGF-like domainDomainDomain
IPR015497 Epidermal growth factor receptor ligandFamilyFamily

Diseases

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