Entity Details

Primary name PHX2B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99453
EntryNamePHX2B_HUMAN
FullNamePaired mesoderm homeobox protein 2B
TaxID9606
Evidenceevidence at transcript level
Length314
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesPHOX2B

GO terms

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GOName
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001764 neuron migration
GO:0002087 regulation of respiratory gaseous exchange by nervous system process
GO:0003357 noradrenergic neuron differentiation
GO:0003358 noradrenergic neuron development
GO:0003360 brainstem development
GO:0005654 nucleoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008285 negative regulation of cell population proliferation
GO:0010001 glial cell differentiation
GO:0010468 regulation of gene expression
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0021533 cell differentiation in hindbrain
GO:0021723 medullary reticular formation development
GO:0021934 hindbrain tangential cell migration
GO:0035914 skeletal muscle cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048483 autonomic nervous system development
GO:0048484 enteric nervous system development
GO:0048485 sympathetic nervous system development
GO:0048486 parasympathetic nervous system development
GO:0048839 inner ear development
GO:0048894 efferent axon development in a lateral line nerve
GO:0060541 respiratory system development
GO:0061452 retrotrapezoid nucleus neuron differentiation
GO:0061549 sympathetic ganglion development
GO:0071542 dopaminergic neuron differentiation
GO:0071773 cellular response to BMP stimulus
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1901166 neural crest cell migration involved in autonomic nervous system development
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017970 Homeobox, conserved siteSiteConserved site

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
PHX2B_HUMANCBP_HUMANBioGRID19191321 details