Entity Details

Primary name PARK7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99497
EntryNamePARK7_HUMAN
FullNameParkinson disease protein 7
TaxID9606
Evidenceevidence at protein level
Length189
SequenceStatuscomplete
DateCreated2004-12-07
DateModified2021-06-02

Ontological Relatives

GenesPARK7

GO terms

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GOName
GO:0000785 chromatin
GO:0001933 negative regulation of protein phosphorylation
GO:0002866 positive regulation of acute inflammatory response to antigenic stimulus
GO:0003713 transcription coactivator activity
GO:0003729 mRNA binding
GO:0005102 signaling receptor binding
GO:0005507 copper ion binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005759 mitochondrial matrix
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0006281 DNA repair
GO:0006469 negative regulation of protein kinase activity
GO:0006517 protein deglycosylation
GO:0006954 inflammatory response
GO:0007005 mitochondrion organization
GO:0007265 Ras protein signal transduction
GO:0007338 single fertilization
GO:0008134 transcription factor binding
GO:0008233 peptidase activity
GO:0008344 adult locomotory behavior
GO:0009438 methylglyoxal metabolic process
GO:0010273 detoxification of copper ion
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016532 superoxide dismutase copper chaperone activity
GO:0016570 histone modification
GO:0016605 PML body
GO:0016684 oxidoreductase activity, acting on peroxide as acceptor
GO:0019249 lactate biosynthetic process
GO:0019826 oxygen sensor activity
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0019955 cytokine binding
GO:0030073 insulin secretion
GO:0030424 axon
GO:0031334 positive regulation of protein-containing complex assembly
GO:0031397 negative regulation of protein ubiquitination
GO:0032091 negative regulation of protein binding
GO:0032148 activation of protein kinase B activity
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032757 positive regulation of interleukin-8 production
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033182 regulation of histone ubiquitination
GO:0033234 negative regulation of protein sumoylation
GO:0033864 positive regulation of NAD(P)H oxidase activity
GO:0034599 cellular response to oxidative stress
GO:0035065 regulation of histone acetylation
GO:0035973 aggrephagy
GO:0036470 tyrosine 3-monooxygenase activator activity
GO:0036471 cellular response to glyoxal
GO:0036478 L-dopa decarboxylase activator activity
GO:0036524 protein deglycase activity
GO:0036526 peptidyl-cysteine deglycation
GO:0036527 peptidyl-arginine deglycation
GO:0036528 peptidyl-lysine deglycation
GO:0036529 protein deglycation, glyoxal removal
GO:0036530 protein deglycation, methylglyoxal removal
GO:0036531 glutathione deglycation
GO:0042593 glucose homeostasis
GO:0042743 hydrogen peroxide metabolic process
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0044297 cell body
GO:0044388 small protein activating enzyme binding
GO:0044390 ubiquitin-like protein conjugating enzyme binding
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045296 cadherin binding
GO:0045340 mercury ion binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046295 glycolate biosynthetic process
GO:0046826 negative regulation of protein export from nucleus
GO:0048471 perinuclear region of cytoplasm
GO:0050681 androgen receptor binding
GO:0050727 regulation of inflammatory response
GO:0050787 detoxification of mercury ion
GO:0050821 protein stabilization
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051444 negative regulation of ubiquitin-protein transferase activity
GO:0051583 dopamine uptake involved in synaptic transmission
GO:0051881 regulation of mitochondrial membrane potential
GO:0051897 positive regulation of protein kinase B signaling
GO:0051899 membrane depolarization
GO:0051920 peroxiredoxin activity
GO:0060081 membrane hyperpolarization
GO:0060548 negative regulation of cell death
GO:0060765 regulation of androgen receptor signaling pathway
GO:0061727 methylglyoxal catabolic process to lactate
GO:0070062 extracellular exosome
GO:0070301 cellular response to hydrogen peroxide
GO:0070994 detection of oxidative stress
GO:0097110 scaffold protein binding
GO:0098793 presynapse
GO:0106044 guanine deglycation
GO:0106045 guanine deglycation, methylglyoxal removal
GO:0106046 guanine deglycation, glyoxal removal
GO:0110095 cellular detoxification of aldehyde
GO:0140041 cellular detoxification of methylglyoxal
GO:1900182 positive regulation of protein localization to nucleus
GO:1901215 negative regulation of neuron death
GO:1901671 positive regulation of superoxide dismutase activity
GO:1901984 negative regulation of protein acetylation
GO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902903 regulation of supramolecular fiber organization
GO:1902958 positive regulation of mitochondrial electron transport, NADH to ubiquinone
GO:1903073 negative regulation of death-inducing signaling complex assembly
GO:1903094 negative regulation of protein K48-linked deubiquitination
GO:1903122 negative regulation of TRAIL-activated apoptotic signaling pathway
GO:1903135 cupric ion binding
GO:1903136 cuprous ion binding
GO:1903168 positive regulation of pyrroline-5-carboxylate reductase activity
GO:1903178 positive regulation of tyrosine 3-monooxygenase activity
GO:1903181 positive regulation of dopamine biosynthetic process
GO:1903189 glyoxal metabolic process
GO:1903197 positive regulation of L-dopa biosynthetic process
GO:1903200 positive regulation of L-dopa decarboxylase activity
GO:1903202 negative regulation of oxidative stress-induced cell death
GO:1903206 negative regulation of hydrogen peroxide-induced cell death
GO:1903208 negative regulation of hydrogen peroxide-induced neuron death
GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903384 negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
GO:1903427 negative regulation of reactive oxygen species biosynthetic process
GO:1903428 positive regulation of reactive oxygen species biosynthetic process
GO:1903599 positive regulation of autophagy of mitochondrion
GO:1905259 negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
GO:1990381 ubiquitin-specific protease binding
GO:1990422 glyoxalase (glycolic acid-forming) activity
GO:2000157 negative regulation of ubiquitin-specific protease activity
GO:2000277 positive regulation of oxidative phosphorylation uncoupler activity
GO:2000679 positive regulation of transcription regulatory region DNA binding
GO:2000825 positive regulation of androgen receptor activity
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Endoplasmic reticulum
Membrane raft
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR002818 DJ-1/PfpIDomainDomain
IPR006287 Protein/nucleic acid deglycase DJ-1FamilyFamily
IPR029062 Class I glutamine amidotransferase-likeFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB09130 CopperDrugbanksmall molecule

Interactions

80 interactions

InteractorPartnerSourcesPublicationsLink
PARK7_HUMANPARK7_HUMANBioGRID, DIP, HPRD, IntAct12761214 12796482 12851414 12855764 14665635 14713311 15502874 15525661 15894486 15983381 16390825 17331951 18922803 20156966 20304780 24947010 29976090 31353306 details
PARK7_HUMANSAE2_HUMANBioGRID, IntAct15983381 details
PARK7_HUMANUBC9_HUMANBioGRID, IntAct15983381 details
PARK7_HUMANDAXX_HUMANBioGRID, IntAct15983381 32814053 details
PARK7_HUMANANDR_HUMANBioGRID, IntAct17510388 details
PARK7_HUMANBBS1_HUMANBioGRID, IntAct18000879 21097510 32814053 details
PARK7_HUMANMTA1_HUMANBioGRID, IntAct20127688 21368136 details
PARK7_HUMANFADD_HUMANBioGRID, IntAct21785459 details
PARK7_HUMANABL1_HUMANMINT23831022 details
PARK7_HUMANKIF1B_HUMANMINT23831022 details
PARK7_HUMANSODC_HUMANBioGRID, IntAct20406884 24947010 24981860 29128334 31536960 details
PARK7_HUMANGOPC_HUMANBioGRID, IntAct25416956 details
PARK7_HUMANOTUB1_HUMANIntAct26752685 32814053 details
PARK7_HUMANSYUA_HUMANBioGRID, DIP15502874 15935068 25058424 details
PARK7_HUMANPCNA_HUMANUniProt26030842 details
PARK7_HUMANA2MG_HUMANIntAct32814053 details
PARK7_HUMANDYN2_HUMANIntAct32814053 details
PARK7_HUMANTOR1A_HUMANIntAct32814053 details
PARK7_HUMANNUP43_HUMANIntAct32814053 details
PARK7_HUMANSPA2L_HUMANIntAct32814053 details
PARK7_HUMANKRA92_HUMANIntAct32814053 details
PARK7_HUMANLDH6B_HUMANIntAct32814053 details
PARK7_HUMANKKCC1_HUMANIntAct32814053 details
PARK7_HUMANWDR61_HUMANIntAct32814053 details
PARK7_HUMANRN111_HUMANIntAct32814053 details
PARK7_HUMANVPS29_HUMANIntAct32814053 details
PARK7_HUMANIQEC1_HUMANIntAct32814053 details
PARK7_HUMANRN112_HUMANIntAct32814053 details
PARK7_HUMANFYN_HUMANIntAct32814053 details
PARK7_HUMANAP2B1_HUMANIntAct32814053 details
PARK7_HUMANA4_HUMANIntAct32814053 details
PARK7_HUMANHD_HUMANIntAct32814053 details
PARK7_HUMANEFCB6_HUMANBioGRID, HPRD12612053 details
PARK7_HUMANPIAS2_HUMANBioGRID, HPRD11477070 12526767 details
PARK7_HUMANPRKN_HUMANBioGRID15525661 17846173 19229105 24242043 details
PARK7_HUMANB2CL1_HUMANBioGRID21852238 details
PARK7_HUMANBAX_HUMANBioGRID21852238 details
PARK7_HUMANSUMO1_HUMANBioGRID, HPRD12526767 12761214 15983381 details
PARK7_HUMANPINK1_HUMANBioGRID16632486 19229105 details
PARK7_HUMANMAP1B_HUMANBioGRID21645326 details
PARK7_HUMANNDUA4_HUMANBioGRID19822128 details
PARK7_HUMANCASA1_HUMANBioGRID20304780 details
PARK7_HUMANVMAT2_HUMANBioGRID22554508 details
PARK7_HUMANPTEN_HUMANBioGRID19885556 21426932 30631154 31891690 details
PARK7_HUMANHIPK1_HUMANBioGRID16390825 details
PARK7_HUMANCASP8_HUMANBioGRID21785459 details
PARK7_HUMANMAPK5_HUMANBioGRID25383140 details
PARK7_HUMANBIP_HUMANBioGRID29976090 details
PARK7_HUMANKKCC2_HUMANBioGRID31232473 details
PARK7_HUMANKAPCA_HUMANBioGRID31353306 details
PARK7_HUMANMTA2_HUMANBioGRID, IntAct20127688 details
PARK7_HUMANOTU7B_HUMANBioGRID, IntAct21097510 details
PARK7_HUMANTR10A_HUMANIntAct21785459 details
PARK7_HUMANRACK1_HUMANIntAct24947010 details
PARK7_HUMANP5CR1_HUMANIntAct23743200 details
PARK7_HUMANVHL_HUMANBioGRID, IntAct24899725 details
PARK7_HUMANTIA1_HUMANMINT29675578 details
PARK7_HUMANIF4A3_HUMANMINT29675578 details
PARK7_HUMANCHIP_HUMANBioGRID15525661 details
PARK7_HUMANHSP74_HUMANBioGRID15525661 20156966 details
PARK7_HUMANPITX3_HUMANBioGRID21368136 details
PARK7_HUMANCHD4_HUMANBioGRID20127688 details
PARK7_HUMANTRAF6_HUMANBioGRID20634198 details
PARK7_HUMANCLCF1_HUMANBioGRID21097510 details
PARK7_HUMANRF1M_HUMANBioGRID21097510 details
PARK7_HUMANNONO_HUMANBioGRID15790595 18439917 details
PARK7_HUMANM3K5_HUMANBioGRID19293155 20213747 details
PARK7_HUMANNU1M_HUMANBioGRID18626009 19822128 details
PARK7_HUMANNDUS3_HUMANBioGRID19822128 details
PARK7_HUMANP53_HUMANBioGRID18042550 22683601 details
PARK7_HUMANSFPQ_HUMANBioGRID15790595 details
PARK7_HUMANSRBP2_HUMANBioGRID22666465 details
PARK7_HUMANTYDP2_HUMANBioGRID19023331 details
PARK7_HUMANBAG1_HUMANBioGRID20156966 details
PARK7_HUMANPML_HUMANBioGRID22683601 details
PARK7_HUMANU2AF2_HUMANBioGRID26641092 details
PARK7_HUMANSQSTM_HUMANBioGRID29976090 details
PARK7_HUMANGRP75_HUMANBioGRID31767755 details
PARK7_HUMANITPR3_HUMANBioGRID31767755 details
PARK7_HUMANVDAC1_HUMANBioGRID31767755 details