Entity Details

Primary name FOXC2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99958
EntryNameFOXC2_HUMAN
FullNameForkhead box protein C2
TaxID9606
Evidenceevidence at protein level
Length501
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesFOXC2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001216 DNA-binding transcription activator activity
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001503 ossification
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001756 somitogenesis
GO:0001946 lymphangiogenesis
GO:0001974 blood vessel remodeling
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007219 Notch signaling pathway
GO:0007498 mesoderm development
GO:0007507 heart development
GO:0008286 insulin receptor signaling pathway
GO:0009653 anatomical structure morphogenesis
GO:0009725 response to hormone
GO:0010595 positive regulation of endothelial cell migration
GO:0014032 neural crest cell development
GO:0016604 nuclear body
GO:0030154 cell differentiation
GO:0030199 collagen fibril organization
GO:0031490 chromatin DNA binding
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0035050 embryonic heart tube development
GO:0035470 positive regulation of vascular wound healing
GO:0042802 identical protein binding
GO:0043010 camera-type eye development
GO:0043565 sequence-specific DNA binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046620 regulation of organ growth
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048343 paraxial mesodermal cell fate commitment
GO:0048703 embryonic viscerocranium morphogenesis
GO:0048844 artery morphogenesis
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060038 cardiac muscle cell proliferation
GO:0072011 glomerular endothelium development
GO:0072112 glomerular visceral epithelial cell differentiation
GO:0072144 glomerular mesangial cell development
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0097746 blood vessel diameter maintenance
GO:0120163 negative regulation of cold-induced thermogenesis
GO:1902257 negative regulation of apoptotic process involved in outflow tract morphogenesis
GO:1990837 sequence-specific double-stranded DNA binding
GO:1990841 promoter-specific chromatin binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001766 Fork head domainDomainDomain
IPR018122 Fork head domain conserved site1SiteConserved site
IPR030456 Fork head domain conserved site 2SiteConserved site
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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