Entity Details

Primary name SOST_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BQB4
EntryNameSOST_HUMAN
FullNameSclerostin
TaxID9606
Evidenceevidence at protein level
Length213
SequenceStatuscomplete
DateCreated2002-03-05
DateModified2021-06-02

Ontological Relatives

GenesSOST

GO terms

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GOName
GO:0001503 ossification
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005794 Golgi apparatus
GO:0008134 transcription factor binding
GO:0008201 heparin binding
GO:0009612 response to mechanical stimulus
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030279 negative regulation of ossification
GO:0030514 negative regulation of BMP signaling pathway
GO:0031333 negative regulation of protein-containing complex assembly
GO:0032991 protein-containing complex
GO:0036122 BMP binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0071374 cellular response to parathyroid hormone stimulus
GO:0090090 negative regulation of canonical Wnt signaling pathway

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR006207 Cystine knot, C-terminalDomainDomain
IPR008835 Sclerostin/Sclerostin domain-containing protein 1FamilyFamily
IPR015665 SclerostinFamilyFamily
IPR029034 Cystine-knot cytokineFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB11866 RomosozumabDrugbankbiotech

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
SOST_HUMANLRP6_HUMANbhf-ucl, BioGRID, DIP, IntAct, UniProt15908424 21471202 21944579 28514442 details
SOST_HUMANLRP4_HUMANBioGRID, IntAct, UniProt21471202 28514442 details
SOST_HUMANPKHF2_HUMANBioGRID, IntAct32296183 details
SOST_HUMANLRP5_HUMANbhf-ucl, BioGRID, IntAct, UniProt15908424 21471202 28514442 details