Entity Details

Primary name FYCO1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BQS8
EntryNameFYCO1_HUMAN
FullNameFYVE and coiled-coil domain-containing protein 1
TaxID9606
Evidenceevidence at protein level
Length1478
SequenceStatuscomplete
DateCreated2006-07-11
DateModified2021-06-02

Ontological Relatives

GenesFYCO1

GO terms

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GOName
GO:0005764 lysosome
GO:0005770 late endosome
GO:0005776 autophagosome
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0046872 metal ion binding
GO:0072383 plus-end-directed vesicle transport along microtubule
GO:1901098 positive regulation of autophagosome maturation

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle
Endosome
Lysosome

Domains

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DomainNameCategoryType
IPR000306 FYVE zinc fingerDomainDomain
IPR004012 RUN domainDomainDomain
IPR009038 GOLD domainDomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR017455 Zinc finger, FYVE-relatedDomainDomain
IPR036598 GOLD domain superfamilyFamilyHomologous superfamily
IPR037213 RUN domain superfamilyFamilyHomologous superfamily
IPR042654 FYVE and coiled-coil domain-containing protein 1FamilyFamily

Diseases

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Disease IDSourceNameDescription
610019 OMIMCataract 18 (CTRCT18)An opacification of the crystalline lens of the eye becoming evident at birth or in infancy. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. The disease is caused by variants affecting the gene represented in this entry. Pathogenic mutations in FYCO1 can affect intracellular transport of autophagocytic vesicles from the perinuclear area to the periphery, leading to an accumulation of large numbers of vesicles and hence loss of lens transparency (PubMed:21636066).