Entity Details

Primary name HIPK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H2X6
EntryNameHIPK2_HUMAN
FullNameHomeodomain-interacting protein kinase 2
TaxID9606
Evidenceevidence at protein level
Length1198
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesHIPK2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001654 eye development
GO:0001934 positive regulation of protein phosphorylation
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006468 protein phosphorylation
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007224 smoothened signaling pathway
GO:0007628 adult walking behavior
GO:0008284 positive regulation of cell population proliferation
GO:0009952 anterior/posterior pattern specification
GO:0010842 retina layer formation
GO:0016604 nuclear body
GO:0016605 PML body
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019048 modulation by virus of host process
GO:0030182 neuron differentiation
GO:0030218 erythrocyte differentiation
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0030578 PML body organization
GO:0032092 positive regulation of protein binding
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043388 positive regulation of DNA binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0045766 positive regulation of angiogenesis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0046332 SMAD binding
GO:0046790 virion binding
GO:0048596 embryonic camera-type eye morphogenesis
GO:0050882 voluntary musculoskeletal movement
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051726 regulation of cell cycle
GO:0060059 embryonic retina morphogenesis in camera-type eye
GO:0060235 lens induction in camera-type eye
GO:0060395 SMAD protein signal transduction
GO:0061072 iris morphogenesis
GO:0071456 cellular response to hypoxia
GO:0090575 RNA polymerase II transcription regulator complex
GO:0097193 intrinsic apoptotic signaling pathway
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901796 regulation of signal transduction by p53 class mediator
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

74 interactions

InteractorPartnerSourcesPublicationsLink
HIPK2_HUMANDX39B_HUMANHPRD, IntAct14667819 details
HIPK2_HUMANMYB_HUMANBioGRID, HPRD, IntAct15082531 16055500 details
HIPK2_HUMANSUMO1_HUMANBioGRID, HPRD, MINT10535925 14609633 15896780 21145359 details
HIPK2_HUMANUBC9_HUMANBioGRID, HPRD, IntAct, MINT10535925 14609633 15896780 15958389 19549727 20936779 details
HIPK2_HUMANTLE1_HUMANMINT15896780 details
HIPK2_HUMANP53_HUMANBioGRID, HPRD, I2D, MINT11740489 11780126 11875057 11925430 15896780 16212962 17349959 21057547 22110707 25313037 25961923 details
HIPK2_HUMANMDM2_HUMANBioGRID, HPRD, MINT16212962 17349959 23826318 details
HIPK2_HUMANRUNX1_HUMANBioGRID, HPRD, MINT16917507 details
HIPK2_HUMANEP300_HUMANBioGRID, MINT16917507 29170424 details
HIPK2_HUMANHMGA1_HUMANHPRD, IntAct11593421 17960875 details
HIPK2_HUMANWSB1_HUMANBioGRID, IntAct18093972 details
HIPK2_HUMANMECP2_HUMANBioGRID, MINT19820693 details
HIPK2_HUMANDCAF7_HUMANBioGRID, MINT20940704 27307198 details
HIPK2_HUMANMKNK1_HUMANBioGRID, IntAct21988832 details
HIPK2_HUMANP63_HUMANBioGRID, HPRD, I2D11925430 21602882 details
HIPK2_HUMANSETX_HUMANUniProt24244371 details
HIPK2_HUMANCHM4B_HUMANBioGRID, HPRD, IntAct16730941 details
HIPK2_HUMANM3K7_HUMANBioGRID, DIP, HPRD15082531 23565059 details
HIPK2_HUMANDAXX_HUMANBioGRID14678985 19465479 23536002 details
HIPK2_HUMANSKI_HUMANBioGRID, HPRD12874272 details
HIPK2_HUMANSMAD1_HUMANBioGRID, HPRD12874272 details
HIPK2_HUMANSMAD2_HUMANBioGRID, HPRD12874272 details
HIPK2_HUMANSMAD3_HUMANBioGRID12874272 details
HIPK2_HUMANT53I1_HUMANBioGRID, HPRD12851404 details
HIPK2_HUMANRANB9_HUMANBioGRID, HPRD12220523 details
HIPK2_HUMANNKX21_HUMANBioGRID, HPRD11438542 details
HIPK2_HUMANTRADD_HUMANBioGRID, HPRD11032752 details
HIPK2_HUMANP73_HUMANBioGRID, HPRD11925430 details
HIPK2_HUMANHIPK2_HUMANBioGRID, HPRD14667819 16917507 17349959 22658722 details
HIPK2_HUMANNLK_HUMANBioGRID, HPRD15082531 details
HIPK2_HUMANMYBA_HUMANBioGRID16055500 details
HIPK2_HUMANSIAH1_HUMANBioGRID18536714 19043406 19250734 23503458 details
HIPK2_HUMANSIAH2_HUMANBioGRID19043406 25313037 details
HIPK2_HUMANGROA_HUMANBioGRID15896780 details
HIPK2_HUMANH2B2E_HUMANBioGRID22658722 details
HIPK2_HUMANSENP1_HUMANBioGRID16253240 details
HIPK2_HUMANPML_HUMANBioGRID19015637 20188669 21145359 21192925 details
HIPK2_HUMANPAX6_HUMANBioGRID, HPRD16407227 details
HIPK2_HUMANZBTB4_HUMANBioGRID19448668 details
HIPK2_HUMANMBP_HUMANBioGRID11120354 details
HIPK2_HUMANAATF_HUMANBioGRID25210797 details
HIPK2_HUMANSUMO2_HUMANBioGRID21145359 details
HIPK2_HUMANSUMO3_HUMANBioGRID21145359 details
HIPK2_HUMANABL1_HUMANBioGRID25944899 details
HIPK2_HUMANPARP1_HUMANBioGRID27787517 details
HIPK2_HUMANSIR1_HUMANBioGRID26113041 details
HIPK2_HUMANCBX3_HUMANBioGRID25151962 details
HIPK2_HUMANZYX_HUMANBioGRID21248071 details
HIPK2_HUMANNTRK1_HUMANBioGRID18378044 details
HIPK2_HUMANNKX25_HUMANHPRD9748262 details
HIPK2_HUMANDX39A_HUMANHPRD14667819 details
HIPK2_HUMANDYR1B_HUMANBioGRID, MINT20940704 details
HIPK2_HUMANDYR1A_HUMANBioGRID, MINT20940704 details
HIPK2_HUMANDISC1_HUMANIntAct31413325 details
HIPK2_HUMANSP100_HUMANBioGRID, HPRD14647468 details
HIPK2_HUMANCBP_HUMANBioGRID, HPRD11740489 details
HIPK2_HUMANFBXW7_HUMANBioGRID, HPRD18765672 details
HIPK2_HUMANFBW1A_HUMANBioGRID, HPRD18765672 details
HIPK2_HUMANCUL1_HUMANBioGRID, HPRD18765672 details
HIPK2_HUMANMYBB_HUMANBioGRID16055500 details
HIPK2_HUMANAXIN1_HUMANBioGRID21057547 23826318 details
HIPK2_HUMANSENP2_HUMANBioGRID15958389 details
HIPK2_HUMANFBX3_HUMANBioGRID18809579 details
HIPK2_HUMANCBX4_HUMANBioGRID21145359 details
HIPK2_HUMANXAF1_HUMANBioGRID25313037 details
HIPK2_HUMANHS71A_HUMANBioGRID27787517 details
HIPK2_HUMANHS71B_HUMANBioGRID27787517 details
HIPK2_HUMANCHIP_HUMANBioGRID27787517 details
HIPK2_HUMANMDM4_HUMANBioGRID25961923 details
HIPK2_HUMANDVL3_HUMANBioGRID28455968 details
HIPK2_HUMANTNR16_HUMANBioGRID18378044 details
HIPK2_HUMANPTC1_HUMANHPRD12874272 details
HIPK2_HUMANNKX31_HUMANHPRD10559189 details
HIPK2_HUMANKAT2B_HUMANHPRD16917507 details