Entity Details

Primary name P63_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H3D4
EntryNameP63_HUMAN
FullNameTumor protein 63
TaxID9606
Evidenceevidence at protein level
Length680
SequenceStatuscomplete
DateCreated2005-01-04
DateModified2021-06-02

Ontological Relatives

GenesTP63

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001501 skeletal system development
GO:0001736 establishment of planar polarity
GO:0002039 p53 binding
GO:0002064 epithelial cell development
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005791 rough endoplasmic reticulum
GO:0006338 chromatin remodeling
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007219 Notch signaling pathway
GO:0007283 spermatogenesis
GO:0007499 ectoderm and mesoderm interaction
GO:0007569 cell aging
GO:0008283 cell population proliferation
GO:0009954 proximal/distal pattern formation
GO:0010259 multicellular organism aging
GO:0010481 epidermal cell division
GO:0010482 regulation of epidermal cell division
GO:0010838 positive regulation of keratinocyte proliferation
GO:0030216 keratinocyte differentiation
GO:0030425 dendrite
GO:0030859 polarized epithelial cell differentiation
GO:0031069 hair follicle morphogenesis
GO:0032991 protein-containing complex
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0036342 post-anal tail morphogenesis
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043589 skin morphogenesis
GO:0045617 negative regulation of keratinocyte differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048485 sympathetic nervous system development
GO:0048807 female genitalia morphogenesis
GO:0050699 WW domain binding
GO:0051262 protein tetramerization
GO:0051402 neuron apoptotic process
GO:0060197 cloacal septation
GO:0060513 prostatic bud formation
GO:0060529 squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0061436 establishment of skin barrier
GO:0097371 MDM2/MDM4 family protein binding
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1902808 positive regulation of cell cycle G1/S phase transition
GO:1904674 positive regulation of somatic stem cell population maintenance
GO:1904888 cranial skeletal system development
GO:2000271 positive regulation of fibroblast apoptotic process
GO:2000381 negative regulation of mesoderm development
GO:2000773 negative regulation of cellular senescence
GO:2001235 positive regulation of apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001660 Sterile alpha motif domainDomainDomain
IPR002117 p53 tumour suppressor familyFamilyFamily
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR010991 p53, tetramerisation domainDomainDomain
IPR011615 p53, DNA-binding domainDomainDomain
IPR012346 p53/RUNT-type transcription factor, DNA-binding domain superfamilyFamilyHomologous superfamily
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR032645 Tumour protein p63FamilyFamily
IPR036674 p53-like tetramerisation domain superfamilyFamilyHomologous superfamily
IPR037611 Tumour protein p63, SAM domainDomainDomain

Diseases

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Interactions

88 interactions

InteractorPartnerSourcesPublicationsLink
P63_HUMANASPP1_HUMANHPRD, MINT14729977 details
P63_HUMANYAP1_HUMANBioGRID, MINT11278685 27780825 details
P63_HUMANROAA_HUMANBioGRID, HPRD, IntAct12692135 20085233 details
P63_HUMANP63_HUMANBioGRID, DIP, HPRD, IntAct10373484 19815500 20085233 21335238 21464285 details
P63_HUMANCABL1_HUMANMINT20559324 details
P63_HUMANBAG6_HUMANBioGRID, IntAct21988832 details
P63_HUMANPINX1_HUMANBioGRID, IntAct21988832 details
P63_HUMANCCNC_HUMANBioGRID, IntAct21988832 details
P63_HUMANGLR_HUMANBioGRID, IntAct21988832 details
P63_HUMANHPT_HUMANBioGRID, IntAct21988832 details
P63_HUMANHEMO_HUMANBioGRID, IntAct21988832 details
P63_HUMANITIH4_HUMANBioGRID, IntAct21988832 details
P63_HUMANA1AG1_HUMANBioGRID, IntAct21988832 details
P63_HUMANCSN6_HUMANBioGRID, IntAct21988832 details
P63_HUMANS35A3_HUMANBioGRID, IntAct21988832 details
P63_HUMANNPS3A_HUMANBioGRID, IntAct21988832 details
P63_HUMANPIN1_HUMANBioGRID, IntAct21741598 32296183 details
P63_HUMANHIPK2_HUMANBioGRID, HPRD, I2D11925430 21602882 details
P63_HUMANPELI2_HUMANBioGRID, IntAct32296183 details
P63_HUMANMCRS1_HUMANBioGRID, IntAct32296183 details
P63_HUMANPELI1_HUMANBioGRID, IntAct32296183 details
P63_HUMANUBS3A_HUMANBioGRID, IntAct32296183 details
P63_HUMANP73_HUMANBioGRID, DIP, HPRD, IntAct10373484 11238924 17446929 19815500 22252508 28514442 details
P63_HUMANITCH_HUMANBioGRID, DIP16908849 20855944 22935697 23370280 25485500 details
P63_HUMANIASPP_HUMANDIP18275817 details
P63_HUMANASPP2_HUMANDIP18275817 details
P63_HUMANRACK1_HUMANBioGRID, IntAct12692135 15467455 details
P63_HUMANB2MG_HUMANIntAct12692135 details
P63_HUMANCTNB1_HUMANIntAct12692135 details
P63_HUMANERAL1_HUMANIntAct12692135 details
P63_HUMANGNDS_HUMANIntAct12692135 details
P63_HUMANSCAF4_HUMANBioGRID, IntAct12692135 details
P63_HUMANEMX1_HUMANBioGRID, IntAct20211142 details
P63_HUMANFBW1A_HUMANBioGRID17965458 details
P63_HUMANMDM2_HUMANBioGRID11714701 20571051 21088494 25417702 details
P63_HUMANMDM4_HUMANBioGRID21088494 details
P63_HUMANWWP1_HUMANBioGRID18806757 20951678 details
P63_HUMANCDN2A_HUMANBioGRID15367673 details
P63_HUMANARF_HUMANBioGRID15367673 details
P63_HUMANUBC9_HUMANBioGRID15539951 15611636 details
P63_HUMANDAXX_HUMANBioGRID12954772 15339933 details
P63_HUMANPML_HUMANBioGRID16007146 details
P63_HUMANZN363_HUMANBioGRID23235527 details
P63_HUMANEP300_HUMANBioGRID, HPRD15965232 23589370 25911675 30986748 details
P63_HUMANKAT2B_HUMANBioGRID15965232 22575646 details
P63_HUMANATF3_HUMANBioGRID24554706 details
P63_HUMANCDC20_HUMANBioGRID29735662 details
P63_HUMANCSK21_HUMANBioGRID12393879 details
P63_HUMANCSK22_HUMANBioGRID12393879 details
P63_HUMANCSK2B_HUMANBioGRID12393879 details
P63_HUMANTDG_HUMANBioGRID18951877 details
P63_HUMANP53_HUMANBioGRID, HPRD, IntAct11238924 19345189 21741598 22575646 24554706 25417702 details
P63_HUMANSMAD2_HUMANIntAct19345189 21741598 details
P63_HUMANHNRPK_HUMANBioGRID, IntAct20085233 details
P63_HUMANHNRPQ_HUMANBioGRID, IntAct20085233 details
P63_HUMANFUS_HUMANBioGRID, IntAct20085233 details
P63_HUMANSATB2_HUMANMINT20829881 details
P63_HUMANKPCD_HUMANMINT26112605 details
P63_HUMANTF65_HUMANBioGRID22020940 details
P63_HUMANBRCA1_HUMANBioGRID21363924 24556685 details
P63_HUMANIKKA_HUMANBioGRID20145131 details
P63_HUMANIKKB_HUMANBioGRID20145131 details
P63_HUMANFBXW7_HUMANBioGRID20571051 details
P63_HUMAN1433S_HUMANBioGRID15467455 details
P63_HUMANSUMO1_HUMANBioGRID15539951 details
P63_HUMANUBE4B_HUMANBioGRID18418053 details
P63_HUMANWWOX_HUMANBioGRID23370280 details
P63_HUMANETV4_HUMANBioGRID21150337 details
P63_HUMANCEBPB_HUMANBioGRID21150337 details
P63_HUMANNFYA_HUMANBioGRID21150337 details
P63_HUMANNFKB1_HUMANBioGRID21150337 details
P63_HUMANSTK11_HUMANBioGRID21150337 details
P63_HUMANR144B_HUMANBioGRID23128396 details
P63_HUMANHIF1A_HUMANBioGRID11971180 details
P63_HUMANCDC16_HUMANBioGRID29735662 details
P63_HUMANANC2_HUMANBioGRID29735662 details
P63_HUMANSTXB4_HUMANBioGRID29735662 details
P63_HUMANKCTD5_HUMANBioGRID29782646 details
P63_HUMANPITX1_HUMANBioGRID30713093 details
P63_HUMANITF2_HUMANBioGRID30986748 details
P63_HUMANCRBN_HUMANBioGRID31591562 details
P63_HUMANHDAC2_HUMANBioGRID31591562 details
P63_HUMANUBP8_HUMANBioGRID31511647 details
P63_HUMANISG15_HUMANBioGRID33024031 details
P63_HUMANUBP28_HUMANBioGRID32128997 details
P63_HUMANGRB2_HUMANHPRD8695800 details
P63_HUMAN2A5A_HUMANHPRD12086851 details
P63_HUMANWT1_HUMANHPRD10744705 details