Entity Details

Primary name NOD2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9HC29
EntryNameNOD2_HUMAN
FullNameNucleotide-binding oligomerization domain-containing protein 2
TaxID9606
Evidenceevidence at protein level
Length1040
SequenceStatuscomplete
DateCreated2002-01-31
DateModified2021-06-02

Ontological Relatives

GenesNOD2

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0002221 pattern recognition receptor signaling pathway
GO:0002227 innate immune response in mucosa
GO:0002253 activation of immune response
GO:0002606 positive regulation of dendritic cell antigen processing and presentation
GO:0002710 negative regulation of T cell mediated immunity
GO:0002720 positive regulation of cytokine production involved in immune response
GO:0002732 positive regulation of dendritic cell cytokine production
GO:0002830 positive regulation of type 2 immune response
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0003779 actin binding
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0006952 defense response
GO:0006965 positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
GO:0007254 JNK cascade
GO:0007584 response to nutrient
GO:0009595 detection of biotic stimulus
GO:0009986 cell surface
GO:0016045 detection of bacterium
GO:0016323 basolateral plasma membrane
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030277 maintenance of gastrointestinal epithelium
GO:0030544 Hsp70 protein binding
GO:0031982 vesicle
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032495 response to muramyl dipeptide
GO:0032498 detection of muramyl dipeptide
GO:0032500 muramyl dipeptide binding
GO:0032689 negative regulation of interferon-gamma production
GO:0032695 negative regulation of interleukin-12 production
GO:0032701 negative regulation of interleukin-18 production
GO:0032703 negative regulation of interleukin-2 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032740 positive regulation of interleukin-17 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0032991 protein-containing complex
GO:0034136 negative regulation of toll-like receptor 2 signaling pathway
GO:0035556 intracellular signal transduction
GO:0038187 pattern recognition receptor activity
GO:0042742 defense response to bacterium
GO:0042834 peptidoglycan binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330 response to exogenous dsRNA
GO:0043406 positive regulation of MAP kinase activity
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045089 positive regulation of innate immune response
GO:0045335 phagocytic vesicle
GO:0045747 positive regulation of Notch signaling pathway
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0046645 positive regulation of gamma-delta T cell activation
GO:0046658 anchored component of plasma membrane
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050700 CARD domain binding
GO:0050727 regulation of inflammatory response
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050766 positive regulation of phagocytosis
GO:0050830 defense response to Gram-positive bacterium
GO:0050871 positive regulation of B cell activation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051353 positive regulation of oxidoreductase activity
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0051879 Hsp90 protein binding
GO:0060585 positive regulation of prostaglandin-endoperoxide synthase activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:0071224 cellular response to peptidoglycan
GO:0071225 cellular response to muramyl dipeptide
GO:0071407 cellular response to organic cyclic compound
GO:0071639 positive regulation of monocyte chemotactic protein-1 production
GO:0090022 regulation of neutrophil chemotaxis
GO:1900017 positive regulation of cytokine production involved in inflammatory response
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1902523 positive regulation of protein K63-linked ubiquitination
GO:1904417 positive regulation of xenophagy
GO:2000110 negative regulation of macrophage apoptotic process
GO:2000363 positive regulation of prostaglandin-E synthase activity

Subcellular Location

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Subcellular Location
Basolateral cell membrane
Cytoplasm
Membrane
Mitochondrion

Domains

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DomainNameCategoryType
IPR001315 CARD domainDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR007111 NACHT nucleoside triphosphataseDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR041075 NOD2, winged helix domainDomainDomain
IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2DomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB13615 MifamurtideDrugbanksmall molecule

Interactions

77 interactions

InteractorPartnerSourcesPublicationsLink
NOD2_HUMANRIPK2_HUMANBioGRID, HPRD, IntAct, MINT11087742 15620648 19592251 21097508 21123652 21931826 22607974 22829933 26670046 27545878 27812135 details
NOD2_HUMANA16L1_HUMANBioGRID, MINT19898471 23376921 27273576 details
NOD2_HUMANTRI27_HUMANBioGRID, IntAct22829933 details
NOD2_HUMANTRIM8_HUMANIntAct22829933 details
NOD2_HUMANTRI50_HUMANIntAct22829933 details
NOD2_HUMANVIME_HUMANBioGRID, IntAct21699783 22684479 27812135 details
NOD2_HUMANGALT2_HUMANBioGRID, IntAct21699783 details
NOD2_HUMANFIS1_HUMANBioGRID, IntAct21699783 details
NOD2_HUMANTLE1_HUMANBioGRID, IntAct21699783 details
NOD2_HUMANKAT5_HUMANBioGRID, IntAct21699783 details
NOD2_HUMAN2A5E_HUMANBioGRID, IntAct21699783 details
NOD2_HUMANNDUAD_HUMANIntAct15753091 details
NOD2_HUMANERBIN_HUMANBioGRID, HPRD, IntAct16203728 30833792 details
NOD2_HUMANXIAP_HUMANBioGRID, DIP, IntAct19667203 22607974 23818254 details
NOD2_HUMANM3K7_HUMANBioGRID15075345 17348859 17965022 details
NOD2_HUMANIRGM_HUMANBioGRID25891078 details
NOD2_HUMANCJ067_HUMANBioGRID27812135 details
NOD2_HUMANDOCK7_HUMANBioGRID27812135 details
NOD2_HUMANDCTN1_HUMANBioGRID27812135 details
NOD2_HUMANGOGB1_HUMANBioGRID27812135 details
NOD2_HUMANLARGN_HUMANBioGRID27812135 details
NOD2_HUMANANKH1_HUMANBioGRID27812135 details
NOD2_HUMANTRI41_HUMANBioGRID27812135 details
NOD2_HUMANCHMP5_HUMANBioGRID27812135 details
NOD2_HUMANENTR1_HUMANBioGRID27812135 details
NOD2_HUMANIKIP_HUMANBioGRID27812135 details
NOD2_HUMANK1C15_HUMANBioGRID27812135 details
NOD2_HUMANPP12C_HUMANBioGRID27812135 details
NOD2_HUMANLDOC1_HUMANBioGRID27812135 details
NOD2_HUMANP2R3B_HUMANBioGRID27812135 details
NOD2_HUMANCHM4B_HUMANBioGRID27812135 details
NOD2_HUMANPDLI5_HUMANBioGRID27812135 details
NOD2_HUMANTACC3_HUMANBioGRID27812135 details
NOD2_HUMANHAP1_HUMANBioGRID27812135 details
NOD2_HUMANANXA2_HUMANBioGRID27812135 details
NOD2_HUMANLUR1L_HUMANBioGRID27812135 details
NOD2_HUMANRL13A_HUMANBioGRID27812135 details
NOD2_HUMANPPBI_HUMANBioGRID27812135 details
NOD2_HUMANTERA_HUMANBioGRID27812135 details
NOD2_HUMANLMNA_HUMANBioGRID27812135 details
NOD2_HUMANWBP11_HUMANBioGRID27812135 details
NOD2_HUMANTNIP1_HUMANBioGRID27812135 details
NOD2_HUMANTPM1_HUMANBioGRID27812135 details
NOD2_HUMANTPM3_HUMANBioGRID27812135 details
NOD2_HUMANTPM4_HUMANBioGRID27812135 details
NOD2_HUMANSCYL1_HUMANBioGRID27812135 details
NOD2_HUMANCCL13_HUMANBioGRID27812135 details
NOD2_HUMANANR17_HUMANMINT23711367 details
NOD2_HUMANSGT1_HUMANBioGRID, DIP17420470 details
NOD2_HUMANCASP1_HUMANBioGRID, DIP15107016 18511561 details
NOD2_HUMANCASP4_HUMANDIP18511561 details
NOD2_HUMANNLRP1_HUMANDIP18511561 details
NOD2_HUMANOLFM4_HUMANDIP20534456 details
NOD2_HUMANS15A3_HUMANDIP24695226 details
NOD2_HUMANS15A4_HUMANDIP24695226 details
NOD2_HUMANSQSTM_HUMANBioGRID, IntAct23437331 30833792 details
NOD2_HUMANHSPB8_HUMANDIP31273097 details
NOD2_HUMANSHRPN_HUMANBioGRID, IntAct22607974 23818254 26670046 details
NOD2_HUMANHOIL1_HUMANBioGRID, IntAct22607974 23818254 26670046 details
NOD2_HUMANRNF31_HUMANBioGRID, IntAct22607974 23818254 26670046 27545878 details
NOD2_HUMANNLRC4_HUMANBioGRID, HPRD11472070 15107016 details
NOD2_HUMANBIRC2_HUMANBioGRID22607974 details
NOD2_HUMANBIRC3_HUMANBioGRID22607974 details
NOD2_HUMANNAT16_HUMANBioGRID22607974 details
NOD2_HUMANNEMO_HUMANBioGRID22607974 details
NOD2_HUMANRIPK1_HUMANBioGRID22607974 details
NOD2_HUMANCASPC_HUMANBioGRID18329614 details
NOD2_HUMANCSN6_HUMANBioGRID17337451 details
NOD2_HUMANTRAF4_HUMANBioGRID21097508 details
NOD2_HUMANTRAF6_HUMANBioGRID23437331 details
NOD2_HUMANNOD2_HUMANBioGRID23437331 details
NOD2_HUMANNOD1_HUMANBioGRID19898471 details
NOD2_HUMANUBC_HUMANBioGRID23300079 details
NOD2_HUMANCYLD_HUMANBioGRID26670046 27545878 details
NOD2_HUMANTNAP3_HUMANBioGRID26670046 details
NOD2_HUMANSPAT2_HUMANBioGRID27545878 details
NOD2_HUMANPRKN_HUMANBioGRID30378174 details