Entity Details

Primary name NLRC4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NPP4
EntryNameNLRC4_HUMAN
FullNameNLR family CARD domain-containing protein 4
TaxID9606
Evidenceevidence at protein level
Length1024
SequenceStatuscomplete
DateCreated2002-01-31
DateModified2021-06-02

Ontological Relatives

GenesNLRC4

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0002218 activation of innate immune response
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954 inflammatory response
GO:0010954 positive regulation of protein processing
GO:0016045 detection of bacterium
GO:0032731 positive regulation of interleukin-1 beta production
GO:0042742 defense response to bacterium
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0045087 innate immune response
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051260 protein homooligomerization
GO:0061133 endopeptidase activator activity
GO:0070269 pyroptosis
GO:0072557 IPAF inflammasome complex
GO:0089720 caspase binding
GO:0097202 activation of cysteine-type endopeptidase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Inflammasome

Domains

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DomainNameCategoryType
IPR001315 CARD domainDomainDomain
IPR007111 NACHT nucleoside triphosphataseDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR040535 NLRC4, helical domainDomainDomain
IPR042220 NLR family CARD domain-containing protein 4FamilyFamily

Diseases

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