Entity Details

Primary name TRI36_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NQ86
EntryNameTRI36_HUMAN
FullNameE3 ubiquitin-protein ligase TRIM36
TaxID9606
Evidenceevidence at protein level
Length728
SequenceStatuscomplete
DateCreated2004-12-07
DateModified2021-06-02

Ontological Relatives

GenesTRIM36

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0000281 mitotic cytokinesis
GO:0001669 acrosomal vesicle
GO:0004842 ubiquitin-protein transferase activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0007051 spindle organization
GO:0007340 acrosome reaction
GO:0008270 zinc ion binding
GO:0043014 alpha-tubulin binding
GO:0051726 regulation of cell cycle
GO:0070507 regulation of microtubule cytoskeleton organization

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic vesicle

Domains

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DomainNameCategoryType
IPR000315 B-box-type zinc fingerDomainDomain
IPR001841 Zinc finger, RING-typeDomainDomain
IPR001870 B30.2/SPRY domainDomainDomain
IPR003879 Butyrophylin-like, SPRY domainDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017903 COS domainDomainDomain
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR027370 RING-type zinc-finger, LisH dimerisation motifDomainDomain
IPR027726 E3 ubiquitin-protein ligase Trim36FamilyFamily
IPR035727 TRIM36, PRY/SPRY domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR040859 Midline-1, COS domainDomainDomain
IPR043136 B30.2/SPRY domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
206500 OMIMAnencephaly (ANPH)An extreme form of neural tube defect resulting in the absence of brain tissues, and death in utero or perinatally. Infants are born with intact spinal cords, cerebellums, and brainstems, but lack formation of neural structures above this level. The skull is only partially formed. ANPH inheritance is autosomal recessive. The disease is caused by variants affecting the gene represented in this entry.