Entity Details

Primary name CYLD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NQC7
EntryNameCYLD_HUMAN
FullNameUbiquitin carboxyl-terminal hydrolase CYLD
TaxID9606
Evidenceevidence at protein level
Length956
SequenceStatuscomplete
DateCreated2004-08-16
DateModified2021-06-02

Ontological Relatives

GenesCYLD

GO terms

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GOName
GO:0004843 thiol-dependent deubiquitinase
GO:0005813 centrosome
GO:0005819 spindle
GO:0005829 cytosol
GO:0005874 microtubule
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007049 cell cycle
GO:0007346 regulation of mitotic cell cycle
GO:0008270 zinc ion binding
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0016055 Wnt signaling pathway
GO:0016579 protein deubiquitination
GO:0019901 protein kinase binding
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032480 negative regulation of type I interferon production
GO:0036064 ciliary basal body
GO:0045087 innate immune response
GO:0046329 negative regulation of JNK cascade
GO:0048471 perinuclear region of cytoplasm
GO:0050727 regulation of inflammatory response
GO:0060544 regulation of necroptotic process
GO:0061578 Lys63-specific deubiquitinase activity
GO:0070064 proline-rich region binding
GO:0070266 necroptotic process
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0070536 protein K63-linked deubiquitination
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097542 ciliary tip
GO:1901223 negative regulation of NIK/NF-kappaB signaling
GO:1902017 regulation of cilium assembly
GO:1903753 negative regulation of p38MAPK cascade
GO:1990108 protein linear deubiquitination
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001242 regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000938 CAP Gly-rich domainDomainDomain
IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolaseDomainDomain
IPR018200 Ubiquitin specific protease, conserved siteSiteConserved site
IPR028889 Ubiquitin specific protease domainDomainDomain
IPR036859 CAP Gly-rich domain superfamilyFamilyHomologous superfamily
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily

Diseases

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Interactions

75 interactions

InteractorPartnerSourcesPublicationsLink
CYLD_HUMANIKKE_HUMANBioGRID, MINT18636086 23453969 29755980 details
CYLD_HUMANTBK1_HUMANBioGRID, MINT18636086 25923723 29755980 details
CYLD_HUMANUBC_HUMANBioGRID, MINT17851586 19373254 20622874 29576527 30388174 32185393 33390248 details
CYLD_HUMANSPAT2_HUMANBioGRID, IntAct, MINT19615732 24981860 27307491 27458237 27545878 27591049 31067453 31762063 details
CYLD_HUMANTBA1A_HUMANBioGRID, MINT18222923 19893491 details
CYLD_HUMANHDAC6_HUMANBioGRID, MINT19893491 20593489 details
CYLD_HUMANNEMO_HUMANBioGRID, HPRD, IntAct12917689 12917690 12917691 15341735 16627981 21988832 22990857 26802121 30561431 31366726 details
CYLD_HUMANITCH_HUMANBioGRID, InnateDB22057290 details
CYLD_HUMANM3K7_HUMANBioGRID18332137 27591049 29291351 32410369 details
CYLD_HUMANTRAIP_HUMANBioGRID, HPRD14676304 details
CYLD_HUMANTRAF2_HUMANBioGRID, HPRD12917691 23405219 27591049 28900035 details
CYLD_HUMANTRAF6_HUMANBioGRID, HPRD12917691 16230348 20622874 26056944 29933112 details
CYLD_HUMANOPTN_HUMANBioGRID21408173 25923723 details
CYLD_HUMANUBE2S_HUMANBioGRID20622874 details
CYLD_HUMANAURKB_HUMANBioGRID20593489 details
CYLD_HUMANPTPA_HUMANBioGRID20593489 details
CYLD_HUMANAKT1_HUMANBioGRID23300340 details
CYLD_HUMANMARE1_HUMANBioGRID24552808 details
CYLD_HUMANMIB2_HUMANBioGRID25565632 31366726 details
CYLD_HUMANP53_HUMANBioGRID27561390 details
CYLD_HUMANCYLD_HUMANBioGRID27591049 28187457 28881612 31067453 31762063 details
CYLD_HUMANDLG4_HUMANBioGRID28973854 details
CYLD_HUMANTRI47_HUMANBioGRID29291351 details
CYLD_HUMANPLK4_HUMANBioGRID31762063 details
CYLD_HUMANCENPV_HUMANBioGRID31260673 details
CYLD_HUMANDDX58_HUMANBioGRID, HPRD, MINT18636086 details
CYLD_HUMANMAVS_HUMANBioGRID, MINT18636086 30410068 details
CYLD_HUMANCE192_HUMANBioGRID, IntAct19615732 22895009 24613305 details
CYLD_HUMANVIP1_HUMANBioGRID18636086 details
CYLD_HUMANRIPK1_HUMANBioGRID17981138 21408173 22848449 28900035 details
CYLD_HUMANPLK1_HUMANBioGRID17495026 details
CYLD_HUMANPMS2_HUMANBioGRID17148452 details
CYLD_HUMANPMS1_HUMANBioGRID17148452 details
CYLD_HUMANTRPA1_HUMANBioGRID16500080 details
CYLD_HUMANBCL3_HUMANBioGRID19893491 details
CYLD_HUMANDVL1_HUMANBioGRID20227366 details
CYLD_HUMANDVL3_HUMANBioGRID20227366 details
CYLD_HUMANSQSTM_HUMANBioGRID19201866 32453962 details
CYLD_HUMANCLIP3_HUMANBioGRID22297296 26017671 details
CYLD_HUMANARHGC_HUMANBioGRID23405219 details
CYLD_HUMANCD209_HUMANBioGRID24867235 details
CYLD_HUMANCE350_HUMANBioGRID25134987 31067453 details
CYLD_HUMANRNF31_HUMANBioGRID26670046 27307491 27458237 27545878 27591049 28189684 details
CYLD_HUMANSHRPN_HUMANBioGRID26670046 27591049 31067453 details
CYLD_HUMANTNFA_HUMANBioGRID26670046 27307491 27458237 27545878 31898971 details
CYLD_HUMANNOD2_HUMANBioGRID26670046 27545878 details
CYLD_HUMANKCC2A_HUMANBioGRID24614225 details
CYLD_HUMANMYD88_HUMANBioGRID26719415 details
CYLD_HUMANTNR1A_HUMANBioGRID24098568 27552911 27591049 30420664 details
CYLD_HUMANSDC4_HUMANBioGRID27279133 details
CYLD_HUMANPLAT4_HUMANBioGRID27279133 details
CYLD_HUMANAPRIO_HUMANBioGRID28900035 details
CYLD_HUMANPRIO_HUMANBioGRID28900035 details
CYLD_HUMANDDB2_HUMANBioGRID28035050 details
CYLD_HUMANCBLB_HUMANBioGRID28572092 details
CYLD_HUMANEGFR_HUMANBioGRID28572092 details
CYLD_HUMANNOX4_HUMANBioGRID28751569 details
CYLD_HUMANTNR9_HUMANBioGRID29296520 details
CYLD_HUMANCTNB1_HUMANBioGRID30323974 31067453 details
CYLD_HUMANSTING_HUMANBioGRID30388174 details
CYLD_HUMANSMAD7_HUMANBioGRID30315770 details
CYLD_HUMANCP131_HUMANBioGRID31067453 details
CYLD_HUMANMIB1_HUMANBioGRID31067453 31462741 details
CYLD_HUMANPCM1_HUMANBioGRID31067453 details
CYLD_HUMANTBG1_HUMANBioGRID31067453 details
CYLD_HUMANTNR6B_HUMANBioGRID29395067 31762063 details
CYLD_HUMANTNR6A_HUMANBioGRID29395067 details
CYLD_HUMANTNR6C_HUMANBioGRID29395067 details
CYLD_HUMANMARF1_HUMANBioGRID29395067 details
CYLD_HUMANULK1_HUMANBioGRID32453962 details
CYLD_HUMANPK3C3_HUMANBioGRID32453962 details
CYLD_HUMANATG5_HUMANBioGRID32453962 details
CYLD_HUMANBECN1_HUMANBioGRID32453962 details
CYLD_HUMANMALT1_HUMANBioGRID33329596 details
CYLD_HUMANTRAF7_HUMANHPRD16230348 details