Entity Details

Primary name SERA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43175
EntryNameSERA_HUMAN
FullNameD-3-phosphoglycerate dehydrogenase
TaxID9606
Evidenceevidence at protein level
Length533
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesPHGDH

GO terms

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GOName
GO:0004617 phosphoglycerate dehydrogenase activity
GO:0005829 cytosol
GO:0006541 glutamine metabolic process
GO:0006544 glycine metabolic process
GO:0006564 L-serine biosynthetic process
GO:0006566 threonine metabolic process
GO:0007420 brain development
GO:0009055 electron transfer activity
GO:0009448 gamma-aminobutyric acid metabolic process
GO:0010468 regulation of gene expression
GO:0019530 taurine metabolic process
GO:0021510 spinal cord development
GO:0021782 glial cell development
GO:0021915 neural tube development
GO:0030060 L-malate dehydrogenase activity
GO:0031175 neuron projection development
GO:0051287 NAD binding
GO:0070062 extracellular exosome
GO:0070314 G1 to G0 transition

Subcellular Location

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Domains

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DomainNameCategoryType
IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domainDomainDomain
IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domainDomainDomain
IPR006236 D-3-phosphoglycerate dehydrogenaseFamilyFamily
IPR029009 Allosteric substrate binding domain superfamilyFamilyHomologous superfamily
IPR029752 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1SiteConserved site
IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved siteSiteConserved site
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule