Entity Details

Primary name PAPS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43252
EntryNamePAPS1_HUMAN
FullNameBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
TaxID9606
Evidenceevidence at protein level
Length624
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesPAPSS1

GO terms

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GOName
GO:0000103 sulfate assimilation
GO:0001501 skeletal system development
GO:0004020 adenylylsulfate kinase activity
GO:0004781 sulfate adenylyltransferase (ATP) activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0016779 nucleotidyltransferase activity
GO:0042803 protein homodimerization activity
GO:0050428 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process

Subcellular Location

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Domains

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DomainNameCategoryType
IPR002650 Sulphate adenylyltransferaseDomainDomain
IPR002891 Adenylyl-sulfate kinaseFamilyFamily
IPR014729 Rossmann-like alpha/beta/alpha sandwich foldFamilyHomologous superfamily
IPR015947 PUA-like superfamilyFamilyHomologous superfamily
IPR024951 Sulphate adenylyltransferase catalytic domainDomainDomain
IPR025980 ATP-sulfurylase PUA-like domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02661 Adenosine-5'-diphosphate-2',3'-vanadateDrugbanksmall molecule
DB03708 Adenosine 5'-phosphosulfateDrugbanksmall molecule
DB09462 GlycerinDrugbanksmall molecule

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
PAPS1_HUMANEF1A1_HUMANBioGRID, HPRD, IntAct16169070 details
PAPS1_HUMANU119A_HUMANBioGRID, HPRD, IntAct16169070 details
PAPS1_HUMANPP16A_HUMANBioGRID, HPRD, IntAct16169070 details
PAPS1_HUMANERRFI_HUMANBioGRID20351267 details