Entity Details

Primary name P4HTM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NXG6
EntryNameP4HTM_HUMAN
FullNameTransmembrane prolyl 4-hydroxylase
TaxID9606
Evidenceevidence at protein level
Length502
SequenceStatuscomplete
DateCreated2003-06-16
DateModified2021-06-02

Ontological Relatives

GenesP4HTM

GO terms

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GOName
GO:0005506 iron ion binding
GO:0005509 calcium ion binding
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0016706 2-oxoglutarate-dependent dioxygenase activity
GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0031418 L-ascorbic acid binding
GO:0045646 regulation of erythrocyte differentiation

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR002048 EF-hand domainDomainDomain
IPR005123 Oxoglutarate/iron-dependent dioxygenaseDomainDomain
IPR006620 Prolyl 4-hydroxylase, alpha subunitDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB00126 Ascorbic acidDrugbanksmall molecule