Entity Details

Primary name HDAC6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UBN7
EntryNameHDAC6_HUMAN
FullNameHistone deacetylase 6
TaxID9606
Evidenceevidence at protein level
Length1215
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesHDAC6

GO terms

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GOName
GO:0000118 histone deacetylase complex
GO:0000209 protein polyubiquitination
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003779 actin binding
GO:0004407 histone deacetylase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005771 multivesicular body
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0005901 caveola
GO:0006476 protein deacetylation
GO:0006515 protein quality control for misfolded or incompletely synthesized proteins
GO:0006886 intracellular protein transport
GO:0007026 negative regulation of microtubule depolymerization
GO:0008013 beta-catenin binding
GO:0008017 microtubule binding
GO:0008270 zinc ion binding
GO:0010506 regulation of autophagy
GO:0010634 positive regulation of epithelial cell migration
GO:0010727 negative regulation of hydrogen peroxide metabolic process
GO:0016234 inclusion body
GO:0016235 aggresome
GO:0016241 regulation of macroautophagy
GO:0016575 histone deacetylation
GO:0019899 enzyme binding
GO:0030424 axon
GO:0030425 dendrite
GO:0031252 cell leading edge
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031593 polyubiquitin modification-dependent protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0031647 regulation of protein stability
GO:0031648 protein destabilization
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0032418 lysosome localization
GO:0032984 protein-containing complex disassembly
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033558 protein deacetylase activity
GO:0034983 peptidyl-lysine deacetylation
GO:0035967 cellular response to topologically incorrect protein
GO:0035973 aggrephagy
GO:0040029 regulation of gene expression, epigenetic
GO:0042826 histone deacetylase binding
GO:0042903 tubulin deacetylase activity
GO:0043014 alpha-tubulin binding
GO:0043130 ubiquitin binding
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0043204 perikaryon
GO:0043242 negative regulation of protein-containing complex disassembly
GO:0045598 regulation of fat cell differentiation
GO:0045861 negative regulation of proteolysis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048156 tau protein binding
GO:0048471 perinuclear region of cytoplasm
GO:0048487 beta-tubulin binding
GO:0048668 collateral sprouting
GO:0051354 negative regulation of oxidoreductase activity
GO:0051646 mitochondrion localization
GO:0051787 misfolded protein binding
GO:0051788 response to misfolded protein
GO:0051879 Hsp90 protein binding
GO:0060271 cilium assembly
GO:0060632 regulation of microtubule-based movement
GO:0060765 regulation of androgen receptor signaling pathway
GO:0060997 dendritic spine morphogenesis
GO:0061734 parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:0070201 regulation of establishment of protein localization
GO:0070301 cellular response to hydrogen peroxide
GO:0070840 dynein complex binding
GO:0070842 aggresome assembly
GO:0070845 polyubiquitinated misfolded protein transport
GO:0070846 Hsp90 deacetylation
GO:0070848 response to growth factor
GO:0071218 cellular response to misfolded protein
GO:0090042 tubulin deacetylation
GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death
GO:1903146 regulation of autophagy of mitochondrion
GO:2000273 positive regulation of signaling receptor activity

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm
Nucleus
Perikaryon

Domains

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DomainNameCategoryType
IPR000286 Histone deacetylase familyFamilyFamily
IPR001607 Zinc finger, UBP-typeDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR023696 Ureohydrolase domain superfamilyFamilyHomologous superfamily
IPR023801 Histone deacetylase domainDomainDomain
IPR037138 Histone deacetylase domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02546 VorinostatDrugbanksmall molecule
DB05015 BelinostatDrugbanksmall molecule
DB05223 PracinostatDrugbanksmall molecule
DB06176 RomidepsinDrugbanksmall molecule
DB06603 PanobinostatDrugbanksmall molecule
DB13346 BufexamacDrugbanksmall molecule

Interactions

192 interactions

InteractorPartnerSourcesPublicationsLink
HDAC6_HUMANTBA1A_HUMANBioGRID, MINT12024216 12486003 12606581 19344692 19893491 19961433 23703321 details
HDAC6_HUMANDCTN1_HUMANIntAct, MINT12024216 32814053 details
HDAC6_HUMANUBC_HUMANBioGRID, HPRD, MINT12354939 15171253 17512543 20129057 21690293 24023063 24035499 25342804 25429107 27182664 28190767 28540657 details
HDAC6_HUMANFYN_HUMANIntAct17474147 details
HDAC6_HUMANH4_HUMANBioGRID, IntAct10220385 21090589 details
HDAC6_HUMANCYLD_HUMANBioGRID, MINT19893491 20593489 details
HDAC6_HUMANRPA2_HUMANBioGRID, IntAct21988832 details
HDAC6_HUMANEGFR_HUMANBioGRID, IntAct20029029 20133936 24658140 25402006 31980649 details
HDAC6_HUMANERBB2_HUMANBioGRID, IntAct20029029 31980649 details
HDAC6_HUMANERBB4_HUMANBioGRID, IntAct20029029 31980649 details
HDAC6_HUMANERBB3_HUMANBioGRID, IntAct20029029 31980649 details
HDAC6_HUMANBBS10_HUMANBioGRID, MINT21900206 details
HDAC6_HUMANF16P1_HUMANBioGRID, MINT21900206 details
HDAC6_HUMANHES1_HUMANBioGRID, MINT21900206 details
HDAC6_HUMANLPXN_HUMANBioGRID, MINT21900206 details
HDAC6_HUMANNACAD_HUMANBioGRID, MINT21900206 details
HDAC6_HUMANNASP_HUMANBioGRID, MINT21900206 details
HDAC6_HUMANDPOA2_HUMANBioGRID, MINT21900206 details
HDAC6_HUMANPDIP2_HUMANBioGRID, MINT21900206 details
HDAC6_HUMANPRDX4_HUMANBioGRID, MINT21900206 details
HDAC6_HUMANZN205_HUMANBioGRID, MINT21900206 details
HDAC6_HUMANG3BP1_HUMANBioGRID, I2D18079183 21532619 32082291 details
HDAC6_HUMANSRC8_HUMANBioGRID, IntAct, MINT17643370 21220424 21847094 details
HDAC6_HUMANKPCA_HUMANBioGRID, MINT21949397 21952047 details
HDAC6_HUMANARBK1_HUMANBioGRID, MINT22193721 details
HDAC6_HUMANAT132_HUMANBioGRID, IntAct22645275 details
HDAC6_HUMANVKOR1_HUMANBioGRID, IntAct21103663 26496610 details
HDAC6_HUMANCEP70_HUMANBioGRID, MINT26112604 details
HDAC6_HUMANPRKN_HUMANBioGRID, IntAct19036992 details
HDAC6_HUMANPROM1_HUMANBioGRID, IntAct23084749 details
HDAC6_HUMANHD_HUMANIntAct32814053 details
HDAC6_HUMANTADBP_HUMANBioGRID, IntAct19910924 23703321 32814053 details
HDAC6_HUMANZBT16_HUMANBioGRID, HPRD15467736 details
HDAC6_HUMANUB2D1_HUMANBioGRID17588522 33020410 details
HDAC6_HUMANUB2D3_HUMANBioGRID17588522 details
HDAC6_HUMANUBE2H_HUMANBioGRID17588522 details
HDAC6_HUMANUB2E1_HUMANBioGRID17588522 details
HDAC6_HUMANEP300_HUMANBioGRID, HPRD12718889 15102857 19344692 22778253 23133622 details
HDAC6_HUMANFNTA_HUMANBioGRID19228685 details
HDAC6_HUMANFNTB_HUMANBioGRID19228685 details
HDAC6_HUMANHS90A_HUMANBioGRID15916966 15937340 18591380 19158084 22367781 23703321 details
HDAC6_HUMANLCOR_HUMANBioGRID12535528 19744931 details
HDAC6_HUMANUBD_HUMANBioGRID19033385 21090589 25422469 details
HDAC6_HUMANTAU_HUMANBioGRID18636984 23962722 28540657 details
HDAC6_HUMANPP1G_HUMANBioGRID14670976 details
HDAC6_HUMANKSYK_HUMANBioGRID16288017 details
HDAC6_HUMANTBB2B_HUMANBioGRID12606581 details
HDAC6_HUMANCDN1A_HUMANBioGRID16082198 details
HDAC6_HUMANTBB2A_HUMANBioGRID, HPRD12024216 12606581 19805354 details
HDAC6_HUMANNR0B2_HUMANBioGRID15835920 details
HDAC6_HUMANAURKA_HUMANBioGRID17604723 details
HDAC6_HUMANTPPP_HUMANBioGRID20308065 31505170 details
HDAC6_HUMANGCR_HUMANBioGRID20018896 details
HDAC6_HUMANMIIP_HUMANBioGRID20008322 details
HDAC6_HUMANCSK22_HUMANBioGRID21486957 details
HDAC6_HUMANFBX11_HUMANBioGRID21090589 details
HDAC6_HUMANPTOV1_HUMANBioGRID21090589 details
HDAC6_HUMANTRI50_HUMANBioGRID22792322 24308962 details
HDAC6_HUMANJDP2_HUMANBioGRID22989952 details
HDAC6_HUMANATF3_HUMANBioGRID22989952 details
HDAC6_HUMANIMA5_HUMANBioGRID22778253 details
HDAC6_HUMANHDAC6_HUMANBioGRID23703321 23752268 24882211 26643866 details
HDAC6_HUMANTBA1B_HUMANBioGRID, HPRD12606581 23703321 23798680 26382850 26643866 details
HDAC6_HUMANMSH2_HUMANBioGRID23703321 24882211 details
HDAC6_HUMANATX3_HUMANBioGRID24685680 details
HDAC6_HUMANADRB2_HUMANBioGRID24561123 details
HDAC6_HUMANMK03_HUMANBioGRID24089523 29259132 details
HDAC6_HUMANMK01_HUMANBioGRID24089523 29259132 details
HDAC6_HUMANISG15_HUMANBioGRID25429107 details
HDAC6_HUMANPAXI_HUMANBioGRID25070956 details
HDAC6_HUMANH31_HUMANBioGRID24722339 details
HDAC6_HUMANABC3G_HUMANBioGRID26105074 details
HDAC6_HUMAN1433Z_HUMANBioGRID25770209 details
HDAC6_HUMANMLH1_HUMANBioGRID24882211 30770470 details
HDAC6_HUMANRNF31_HUMANBioGRID28319114 details
HDAC6_HUMANGDIR1_HUMANBioGRID26719334 details
HDAC6_HUMANSEPT7_HUMANBioGRID24113571 details
HDAC6_HUMANKPCZ_HUMANBioGRID25860570 details
HDAC6_HUMANHTSF1_HUMANBioGRID21220424 details
HDAC6_HUMANHTAI2_HUMANBioGRID21220424 details
HDAC6_HUMANDYL2_HUMANBioGRID31505170 details
HDAC6_HUMANUBP10_HUMANBioGRID32382008 details
HDAC6_HUMANCHK1_HUMANBioGRID33020410 details
HDAC6_HUMANUBB_HUMANHPRD12354939 details
HDAC6_HUMANTBA4A_HUMANHPRD, MINT12024216 details
HDAC6_HUMANHDA11_HUMANBioGRID, HPRD, IntAct11948178 details
HDAC6_HUMANSIR2_HUMANBioGRID, HPRD, IntAct12620231 17516032 details
HDAC6_HUMANBRMS1_HUMANBioGRID, IntAct16919237 details
HDAC6_HUMANSRSF2_HUMANMINT21157427 details
HDAC6_HUMANEGF_HUMANIntAct20029029 details
HDAC6_HUMANPLAP_HUMANBioGRID, HPRD, IntAct11689694 23703321 23752268 26496610 details
HDAC6_HUMANCTNB1_HUMANbhf-ucl, BioGRID, IntAct18356165 23084749 details
HDAC6_HUMANCAV1_HUMANbhf-ucl, BioGRID18356165 details
HDAC6_HUMANKALRN_HUMANIntAct23284848 details
HDAC6_HUMANSNCAP_HUMANIntAct23284848 details
HDAC6_HUMANMLF1_HUMANIntAct25036637 details
HDAC6_HUMANMLF2_HUMANIntAct25036637 details
HDAC6_HUMANNUDC3_HUMANIntAct25036637 details
HDAC6_HUMANPSMD2_HUMANIntAct25036637 details
HDAC6_HUMANSTIP1_HUMANIntAct25036637 details
HDAC6_HUMANCHIP_HUMANBioGRID, IntAct22492994 25036637 details
HDAC6_HUMANCYBP_HUMANIntAct25036637 details
HDAC6_HUMANGARS_HUMANBioGRID, IntAct29415205 details
HDAC6_HUMANHDAC9_HUMANBioGRID, IntAct25873389 details
HDAC6_HUMANMYD88_HUMANBioGRID, IntAct20837465 29281743 31268348 details
HDAC6_HUMANLRRK2_HUMANBioGRID, IntAct29519959 details
HDAC6_HUMANBCOR_HUMANBioGRID, HPRD10898795 details
HDAC6_HUMANRUNX2_HUMANBioGRID, HPRD12391164 23618908 details
HDAC6_HUMANMTG16_HUMANBioGRID11533236 details
HDAC6_HUMANDNJB6_HUMANBioGRID20159555 details
HDAC6_HUMANDNJB8_HUMANBioGRID20159555 details
HDAC6_HUMANNR4A1_HUMANBioGRID19321449 details
HDAC6_HUMANMARE1_HUMANBioGRID19737819 details
HDAC6_HUMANACTZ_HUMANBioGRID19737819 details
HDAC6_HUMANFAT1_HUMANBioGRID19033385 details
HDAC6_HUMANSMAD7_HUMANBioGRID15831498 15831516 details
HDAC6_HUMANHIF1A_HUMANBioGRID16951198 details
HDAC6_HUMANCFTR_HUMANBioGRID14675537 22069321 31501480 details
HDAC6_HUMANDIAP3_HUMANBioGRID15976449 details
HDAC6_HUMANDYL1_HUMANBioGRID15937109 31024851 details
HDAC6_HUMANBIP_HUMANBioGRID20371724 23703321 details
HDAC6_HUMANBCL3_HUMANBioGRID, HPRD15469820 details
HDAC6_HUMANHSPB1_HUMANBioGRID22238643 details
HDAC6_HUMANGSK3A_HUMANBioGRID22022450 details
HDAC6_HUMANGSK3B_HUMANBioGRID22022450 details
HDAC6_HUMANSQSTM_HUMANBioGRID22674379 24086678 26363065 30469013 31857589 32082291 details
HDAC6_HUMANRS6_HUMANBioGRID22367689 23703321 details
HDAC6_HUMANRL36A_HUMANBioGRID22367689 details
HDAC6_HUMANBIRC5_HUMANBioGRID22334690 details
HDAC6_HUMANXPO1_HUMANBioGRID22334690 26673895 details
HDAC6_HUMANBAX_HUMANBioGRID21847364 details
HDAC6_HUMANXRCC6_HUMANBioGRID21847364 25299772 details
HDAC6_HUMANTBB5_HUMANBioGRID19961433 23703321 26643866 details
HDAC6_HUMANCDC20_HUMANBioGRID19167333 details
HDAC6_HUMANSODC_HUMANBioGRID23580651 details
HDAC6_HUMANRD23B_HUMANBioGRID23703321 29876933 details
HDAC6_HUMANKPYM_HUMANBioGRID23703321 26643866 29278704 details
HDAC6_HUMANMEF2B_HUMANBioGRID23974956 details
HDAC6_HUMANRANB9_HUMANBioGRID24795145 28668087 details
HDAC6_HUMANELAV1_HUMANBioGRID18644987 30009671 details
HDAC6_HUMANDYHC1_HUMANBioGRID25342804 details
HDAC6_HUMANACTB_HUMANBioGRID25342804 30009671 details
HDAC6_HUMANMYH10_HUMANBioGRID25342804 26643866 details
HDAC6_HUMANDDIT3_HUMANBioGRID17872950 details
HDAC6_HUMANRIPR2_HUMANBioGRID24687993 details
HDAC6_HUMANDYSF_HUMANBioGRID24687993 details
HDAC6_HUMANCLIP1_HUMANBioGRID24474193 details
HDAC6_HUMANKAT5_HUMANBioGRID24302573 details
HDAC6_HUMANPP1A_HUMANBioGRID16186112 details
HDAC6_HUMANBANP_HUMANBioGRID25299772 26080397 details
HDAC6_HUMANKHDR1_HUMANBioGRID26080397 details
HDAC6_HUMANNLRP3_HUMANBioGRID26471297 details
HDAC6_HUMANMFN2_HUMANBioGRID26210454 details
HDAC6_HUMANITCH_HUMANBioGRID26508657 details
HDAC6_HUMANMA7D3_HUMANBioGRID24614595 details
HDAC6_HUMANTF65_HUMANBioGRID26388610 details
HDAC6_HUMANDDX58_HUMANBioGRID26746851 details
HDAC6_HUMANMSH3_HUMANBioGRID24882211 details
HDAC6_HUMANMSH6_HUMANBioGRID24882211 details
HDAC6_HUMANMRE11_HUMANBioGRID24882211 details
HDAC6_HUMANRAD50_HUMANBioGRID24882211 details
HDAC6_HUMANNBN_HUMANBioGRID24882211 details
HDAC6_HUMANTWST1_HUMANBioGRID28779345 details
HDAC6_HUMANRO52_HUMANBioGRID26643866 32796032 details
HDAC6_HUMANSTAT3_HUMANBioGRID26775640 details
HDAC6_HUMANJAK2_HUMANBioGRID26775640 details
HDAC6_HUMANPTN11_HUMANBioGRID26775640 details
HDAC6_HUMANPTPA_HUMANBioGRID26775640 details
HDAC6_HUMANCDK1_HUMANBioGRID28855742 details
HDAC6_HUMANCUL1_HUMANBioGRID28599312 details
HDAC6_HUMANCUL3_HUMANBioGRID28599312 details
HDAC6_HUMANSPOP_HUMANBioGRID28599312 details
HDAC6_HUMANMKLN1_HUMANBioGRID28668087 details
HDAC6_HUMANSTK4_HUMANBioGRID26657153 details
HDAC6_HUMANTERA_HUMANBioGRID, HPRD11689694 27623077 details
HDAC6_HUMANAKT1_HUMANBioGRID28628306 details
HDAC6_HUMANPTN1_HUMANBioGRID29278704 details
HDAC6_HUMANRUVB2_HUMANBioGRID29278704 details
HDAC6_HUMANPDIA6_HUMANBioGRID29278704 details
HDAC6_HUMANTGM3_HUMANBioGRID29278704 details
HDAC6_HUMANRUVB1_HUMANBioGRID29278704 details
HDAC6_HUMANREQU_HUMANBioGRID29278704 details
HDAC6_HUMANERAP1_HUMANBioGRID29278704 details
HDAC6_HUMANCNTP1_HUMANBioGRID29278704 details
HDAC6_HUMANULK1_HUMANBioGRID30335599 details
HDAC6_HUMANCCAR2_HUMANBioGRID32152128 details
HDAC6_HUMANAFAD_HUMANBioGRID31264358 details
HDAC6_HUMAN1433E_HUMANBioGRID23472066 details
HDAC6_HUMANSYUA_HUMANBioGRID32655357 details
HDAC6_HUMANPSB2_HUMANBioGRID32723828 details
HDAC6_HUMANTIF1B_HUMANBioGRID32869873 details
HDAC6_HUMANZ354C_HUMANBioGRID32869873 details