Entity Details

Primary name SPAST_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UBP0
EntryNameSPAST_HUMAN
FullNameSpastin
TaxID9606
Evidenceevidence at protein level
Length616
SequenceStatuscomplete
DateCreated2001-01-11
DateModified2021-06-02

Ontological Relatives

GenesSPAST

GO terms

Show/Hide Table
GOName
GO:0000281 mitotic cytokinesis
GO:0001578 microtubule bundle formation
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005811 lipid droplet
GO:0005813 centrosome
GO:0005819 spindle
GO:0005829 cytosol
GO:0005874 microtubule
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0007084 mitotic nuclear membrane reassembly
GO:0007409 axonogenesis
GO:0008017 microtubule binding
GO:0008089 anterograde axonal transport
GO:0008568 microtubule-severing ATPase activity
GO:0010458 exit from mitosis
GO:0016021 integral component of membrane
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0019896 axonal transport of mitochondrion
GO:0030496 midbody
GO:0031117 positive regulation of microtubule depolymerization
GO:0031122 cytoplasmic microtubule organization
GO:0031410 cytoplasmic vesicle
GO:0031468 nuclear membrane reassembly
GO:0031965 nuclear membrane
GO:0032467 positive regulation of cytokinesis
GO:0032506 cytokinetic process
GO:0034214 protein hexamerization
GO:0043014 alpha-tubulin binding
GO:0044877 protein-containing complex binding
GO:0048471 perinuclear region of cytoplasm
GO:0048487 beta-tubulin binding
GO:0051013 microtubule severing
GO:0051228 mitotic spindle disassembly
GO:0051260 protein homooligomerization
GO:0061640 cytoskeleton-dependent cytokinesis
GO:0070062 extracellular exosome
GO:0071782 endoplasmic reticulum tubular network
GO:0090148 membrane fission
GO:1904115 axon cytoplasm

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Endoplasmic reticulum
Endoplasmic reticulum membrane
Endosome
Lipid droplet
Membrane
Midbody
Nucleus
Nucleus membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR003593 AAA+ ATPase domainDomainDomain
IPR003959 ATPase, AAA-type, coreDomainDomain
IPR003960 ATPase, AAA-type, conserved siteSiteConserved site
IPR007330 MIT domainDomainDomain
IPR015415 Vps4 oligomerisation, C-terminalDomainDomain
IPR017179 SpastinFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR035106 Spastin, chordateFamilyFamily
IPR041569 AAA ATPase, AAA+ lid domainDomainDomain

Diseases

Show/Hide Table