Entity Details

Primary name KS6A6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UK32
EntryNameKS6A6_HUMAN
FullNameRibosomal protein S6 kinase alpha-6
TaxID9606
Evidenceevidence at protein level
Length745
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesRPS6KA6

GO terms

Show/Hide Table
GOName
GO:0000287 magnesium ion binding
GO:0001650 fibrillar center
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004711 ribosomal protein S6 kinase activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007165 signal transduction
GO:0007417 central nervous system development
GO:0018105 peptidyl-serine phosphorylation
GO:0045992 negative regulation of embryonic development
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000381 negative regulation of mesoderm development

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016239 Ribosomal protein S6 kinase IIFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR017892 Protein kinase, C-terminalDomainDomain
IPR041906 Ribosomal S6 kinase, N-terminal catalytic domainDomainDomain

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

30 interactions

InteractorPartnerSourcesPublicationsLink
KS6A6_HUMANNR4A1_HUMANBioGRID, HPRD, IntAct16169070 details
KS6A6_HUMANMK03_HUMANBioGRID, MINT21900206 31678930 details
KS6A6_HUMANADIRF_HUMANBioGRID, MINT21900206 details
KS6A6_HUMANERG28_HUMANBioGRID, MINT21900206 details
KS6A6_HUMANSYNE4_HUMANBioGRID, MINT21900206 details
KS6A6_HUMANCEBPZ_HUMANBioGRID, MINT21900206 details
KS6A6_HUMANCENPB_HUMANBioGRID, MINT21900206 details
KS6A6_HUMANTETN_HUMANBioGRID, MINT21900206 details
KS6A6_HUMANDHX34_HUMANBioGRID, MINT21900206 details
KS6A6_HUMANDJC13_HUMANBioGRID, MINT21900206 details
KS6A6_HUMANDNMT1_HUMANBioGRID, MINT21900206 details
KS6A6_HUMANFBN3_HUMANBioGRID, MINT21900206 details
KS6A6_HUMANLMO4_HUMANBioGRID, MINT21900206 details
KS6A6_HUMANMASP1_HUMANBioGRID, MINT21900206 details
KS6A6_HUMANMED24_HUMANBioGRID, MINT21900206 details
KS6A6_HUMANMICA1_HUMANBioGRID, MINT21900206 details
KS6A6_HUMANEM55_HUMANBioGRID, MINT21900206 details
KS6A6_HUMANSUH_HUMANBioGRID, MINT21900206 details
KS6A6_HUMANRLA1_HUMANBioGRID, MINT21900206 details
KS6A6_HUMANRXRA_HUMANBioGRID, MINT21900206 details
KS6A6_HUMANS30BP_HUMANBioGRID, MINT21900206 details
KS6A6_HUMANSPTN4_HUMANBioGRID, MINT21900206 details
KS6A6_HUMANUFM1_HUMANBioGRID, MINT21900206 details
KS6A6_HUMANZN227_HUMANBioGRID, MINT21900206 details
KS6A6_HUMANZN746_HUMANBioGRID, MINT21900206 details
KS6A6_HUMANFZD5_HUMANBioGRID, MINT21900206 details
KS6A6_HUMANSPRE2_HUMANBioGRID, IntAct32296183 details
KS6A6_HUMANUBC9_HUMANBioGRID17709345 details
KS6A6_HUMANA4_HUMANBioGRID21832049 details
KS6A6_HUMANHS90B_HUMANIntAct22939624 details