Entity Details

Primary name ALK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UM73
EntryNameALK_HUMAN
FullNameALK tyrosine kinase receptor
TaxID9606
Evidenceevidence at protein level
Length1620
SequenceStatuscomplete
DateCreated2002-03-27
DateModified2021-06-02

Ontological Relatives

GenesALK

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0004704 NF-kappaB-inducing kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0016310 phosphorylation
GO:0021766 hippocampus development
GO:0030534 adult behavior
GO:0032991 protein-containing complex
GO:0033674 positive regulation of kinase activity
GO:0036269 swimming behavior
GO:0042127 regulation of cell population proliferation
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043235 receptor complex
GO:0045664 regulation of neuron differentiation
GO:0046777 protein autophosphorylation
GO:0048666 neuron development
GO:0050995 negative regulation of lipid catabolic process
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060159 regulation of dopamine receptor signaling pathway
GO:0070062 extracellular exosome
GO:0090648 response to environmental enrichment
GO:0097009 energy homeostasis
GO:1900006 positive regulation of dendrite development

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000998 MAM domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR002011 Tyrosine-protein kinase, receptor class II, conserved siteSiteConserved site
IPR002172 Low-density lipoprotein (LDL) receptor class A repeatRepeatRepeat
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR026830 ALK tyrosine kinase receptorFamilyFamily
IPR036055 LDL receptor-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00171 ATPDrugbanksmall molecule
DB08865 CrizotinibDrugbanksmall molecule
DB09063 CeritinibDrugbanksmall molecule
DB11363 AlectinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB12130 LorlatinibDrugbanksmall molecule
DB12141 GilteritinibDrugbanksmall molecule
DB12267 BrigatinibDrugbanksmall molecule

Interactions

62 interactions

InteractorPartnerSourcesPublicationsLink
ALK_HUMANPTPRG_HUMANIntAct19167335 details
ALK_HUMANPTPRB_HUMANIntAct19167335 details
ALK_HUMANPTPRJ_HUMANIntAct19167335 details
ALK_HUMANPTPRZ_HUMANHPRD, MINT17681947 details
ALK_HUMANALK_HUMANHPRD, IntAct25517749 9174053 9819383 details
ALK_HUMANALKL1_HUMANUniProt26418745 details
ALK_HUMANDUS19_HUMANBioGRID, MINT28065597 details
ALK_HUMANPPM1A_HUMANBioGRID, MINT28065597 details
ALK_HUMANPTN_HUMANBioGRID, HPRD11278720 details
ALK_HUMANPLCG1_HUMANBioGRID, HPRD11888936 14968112 9174053 9819383 details
ALK_HUMANGRB2_HUMANBioGRID14968112 16105984 9819383 details
ALK_HUMANNEMO_HUMANBioGRID20098747 details
ALK_HUMANNIPA_HUMANBioGRID12748172 details
ALK_HUMANP85A_HUMANBioGRID16135792 details
ALK_HUMANERBB2_HUMANBioGRID30898150 details
ALK_HUMANMK_HUMANBioGRID, HPRD12122009 details
ALK_HUMANM3K3_HUMANIntAct14743216 details
ALK_HUMANVAV3_HUMANMINT17998938 details
ALK_HUMANHS90B_HUMANIntAct22939624 details
ALK_HUMANALKL2_HUMANUniProt26418745 details
ALK_HUMANSHC1_HUMANBioGRID, HPRD11888936 9174053 details
ALK_HUMANJAK3_HUMANBioGRID, HPRD11850821 14968112 details
ALK_HUMANSHC3_HUMANBioGRID, HPRD12185581 details
ALK_HUMANRAB35_HUMANBioGRID14968112 details
ALK_HUMANCH60_HUMANBioGRID14968112 details
ALK_HUMANM3K4_HUMANBioGRID14968112 details
ALK_HUMANSOCS1_HUMANBioGRID14968112 details
ALK_HUMANPK3CB_HUMANBioGRID14968112 details
ALK_HUMANRAD17_HUMANBioGRID14968112 details
ALK_HUMANIRF7_HUMANBioGRID14968112 details
ALK_HUMANEPHB2_HUMANBioGRID14968112 details
ALK_HUMANIF4B_HUMANBioGRID14968112 details
ALK_HUMANJIP3_HUMANBioGRID14968112 details
ALK_HUMANCENPF_HUMANBioGRID14968112 details
ALK_HUMANPLCB2_HUMANBioGRID14968112 details
ALK_HUMANPDX1_HUMANBioGRID14968112 details
ALK_HUMANSTAT3_HUMANBioGRID14968112 details
ALK_HUMANMP2K7_HUMANBioGRID14968112 details
ALK_HUMANJAK2_HUMANBioGRID14968112 details
ALK_HUMANM3K5_HUMANBioGRID14968112 details
ALK_HUMANMEP1B_HUMANBioGRID14968112 details
ALK_HUMANGAK_HUMANBioGRID14968112 details
ALK_HUMANEPHA1_HUMANBioGRID14968112 details
ALK_HUMANUBS3A_HUMANBioGRID14968112 details
ALK_HUMANIF2M_HUMANBioGRID14968112 details
ALK_HUMANMYLK_HUMANBioGRID14968112 details
ALK_HUMANM3K1_HUMANBioGRID14968112 details
ALK_HUMANMK01_HUMANBioGRID14968112 details
ALK_HUMANSOCS5_HUMANBioGRID14968112 details
ALK_HUMANCDK13_HUMANBioGRID14968112 details
ALK_HUMANSMC6_HUMANBioGRID14968112 details
ALK_HUMANIRS4_HUMANBioGRID14968112 details
ALK_HUMANK1C18_HUMANBioGRID14968112 details
ALK_HUMANK2C74_HUMANBioGRID14968112 details
ALK_HUMANIRS1_HUMANBioGRID, HPRD14968112 9174053 details
ALK_HUMANACK1_HUMANBioGRID19815557 details
ALK_HUMANERRFI_HUMANBioGRID19815557 details
ALK_HUMANHS90A_HUMANBioGRID22939624 details
ALK_HUMANKPCT_HUMANBioGRID14968112 details
ALK_HUMANMYPC2_HUMANBioGRID14968112 details
ALK_HUMANTNR8_HUMANHPRD10641597 details
ALK_HUMANNPM_HUMANHPRD11888936 details