| Domain | Name | Category | Type |
| IPR000504 | RNA recognition motif domain | Domain | Domain |
| IPR001214 | SET domain | Domain | Domain |
| IPR003616 | Post-SET domain | Domain | Domain |
| IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily | Family | Homologous superfamily |
| IPR024657 | COMPASS complex Set1 subunit, N-SET domain | Domain | Domain |
| IPR034468 | Set1B, RNA recognition motif | Domain | Domain |
| IPR035979 | RNA-binding domain superfamily | Family | Homologous superfamily |
| IPR037842 | Histone-lysine N-methyltransferase SETD1B | Family | Family |
| IPR044570 | Histone-lysine N-methyltransferase Set1-like | Family | Family |