Entity Details

Primary name TLN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y490
EntryNameTLN1_HUMAN
FullNameTalin-1
TaxID9606
Evidenceevidence at protein level
Length2541
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesTLN1

GO terms

Show/Hide Table
GOName
GO:0001726 ruffle
GO:0001786 phosphatidylserine binding
GO:0002576 platelet degranulation
GO:0005178 integrin binding
GO:0005200 structural constituent of cytoskeleton
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0005925 focal adhesion
GO:0006936 muscle contraction
GO:0007043 cell-cell junction assembly
GO:0007044 cell-substrate junction assembly
GO:0007229 integrin-mediated signaling pathway
GO:0009986 cell surface
GO:0016032 viral process
GO:0017166 vinculin binding
GO:0030274 LIM domain binding
GO:0030866 cortical actin cytoskeleton organization
GO:0032587 ruffle membrane
GO:0033622 integrin activation
GO:0035091 phosphatidylinositol binding
GO:0036498 IRE1-mediated unfolded protein response
GO:0045296 cadherin binding
GO:0051015 actin filament binding
GO:0070062 extracellular exosome
GO:0070527 platelet aggregation
GO:0098609 cell-cell adhesion

Subcellular Location

Show/Hide Table
Subcellular Location
Cell junction
Cell projection
Cell surface
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR000299 FERM domainDomainDomain
IPR002558 I/LWEQ domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR014352 FERM/acyl-CoA-binding protein superfamilyFamilyHomologous superfamily
IPR015009 Vinculin-binding site-containing domainDomainDomain
IPR015224 Talin, centralDomainDomain
IPR019747 FERM conserved siteSiteConserved site
IPR019748 FERM central domainDomainDomain
IPR019749 Band 4.1 domainDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR032425 Talin, N-terminal F0 domainDomainDomain
IPR035963 FERM superfamily, second domainFamilyHomologous superfamily
IPR035964 I/LWEQ domain superfamilyFamilyHomologous superfamily
IPR036476 Talin, central domain superfamilyFamilyHomologous superfamily
IPR036723 Alpha-catenin/vinculin-like superfamilyFamilyHomologous superfamily
IPR037438 Talin-1/2, rod-segmentDomainDomain

Diseases

Show/Hide Table

Interactions

39 interactions

InteractorPartnerSourcesPublicationsLink
TLN1_HUMANERBB2_HUMANBioGRID, MINT16273093 details
TLN1_HUMANEGFR_HUMANBioGRID, MINT16273093 details
TLN1_HUMANITB3_HUMANBioGRID, HPRD, MINT10497223 11412103 11932255 12606711 16546176 19843520 details
TLN1_HUMANABI1_HUMANBioGRID, IntAct23414517 details
TLN1_HUMANITB1_HUMANBioGRID, mbinfo11279249 14691141 19843520 22939629 details
TLN1_HUMANVINC_HUMANBioGRID, HPRD, IntAct15070891 15988023 18056416 26496610 26923917 details
TLN1_HUMANMTR1A_HUMANBioGRID, IntAct26514267 details
TLN1_HUMANMTR1B_HUMANBioGRID, IntAct26514267 details
TLN1_HUMANNAL12_HUMANI2D32226298 details
TLN1_HUMANPAXI_HUMANBioGRID, HPRD22761432 7534286 8641358 9054445 details
TLN1_HUMANFAK1_HUMANBioGRID25391654 7622520 9442086 details
TLN1_HUMANITA1_HUMANBioGRID, HPRD11336656 details
TLN1_HUMANCDK5_HUMANBioGRID19363486 details
TLN1_HUMANSMUF1_HUMANBioGRID19363486 details
TLN1_HUMANDAG1_HUMANBioGRID18341635 details
TLN1_HUMANTBA1A_HUMANBioGRID18341635 details
TLN1_HUMAN1433T_HUMANBioGRID15161933 details
TLN1_HUMANDOK1_HUMANBioGRID19843520 details
TLN1_HUMANITB7_HUMANBioGRID, HPRD12606711 19843520 details
TLN1_HUMANSUMO2_HUMANBioGRID32786267 details
TLN1_HUMANHS90A_HUMANBioGRID31273033 details
TLN1_HUMANLRP2_HUMANHPRD10827173 details
TLN1_HUMAN1433Z_HUMANMINT15161933 details
TLN1_HUMANDISC1_HUMANIntAct31413325 details
TLN1_HUMANFAK2_HUMANBioGRID, HPRD9442086 details
TLN1_HUMANTERF2_HUMANBioGRID20811636 details
TLN1_HUMANBLNK_HUMANBioGRID21822214 details
TLN1_HUMANITA4_HUMANBioGRID22623428 details
TLN1_HUMANPI51C_HUMANBioGRID14691141 23572508 26149501 27775029 details
TLN1_HUMANU2AF2_HUMANBioGRID26641092 details
TLN1_HUMANSRC_HUMANBioGRID23242524 details
TLN1_HUMANTES_HUMANBioGRID, HPRD12571287 12695497 28378594 details
TLN1_HUMANITA5_HUMANBioGRID28263956 details
TLN1_HUMANITB2_HUMANHPRD12606711 2150484 details
TLN1_HUMANPKD1_HUMANHPRD11113628 details
TLN1_HUMANNRAP_HUMANHPRD10320340 details
TLN1_HUMANACTS_HUMANHPRD10581178 details
TLN1_HUMANITA2B_HUMANHPRD16546176 details
TLN1_HUMANITB5_HUMANHPRD12606711 details