Entity Details

Primary name RPGF2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y4G8
EntryNameRPGF2_HUMAN
FullNameRap guanine nucleotide exchange factor 2
TaxID9606
Evidenceevidence at protein level
Length1499
SequenceStatuscomplete
DateCreated2003-08-29
DateModified2021-06-02

Ontological Relatives

GenesRAPGEF2

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001568 blood vessel development
GO:0001764 neuron migration
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005509 calcium ion binding
GO:0005737 cytoplasm
GO:0005770 late endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0005923 bicellular tight junction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0008285 negative regulation of cell population proliferation
GO:0010976 positive regulation of neuron projection development
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0019933 cAMP-mediated signaling
GO:0019992 diacylglycerol binding
GO:0021591 ventricular system development
GO:0021884 forebrain neuron development
GO:0030033 microvillus assembly
GO:0030139 endocytic vesicle
GO:0030165 PDZ domain binding
GO:0030552 cAMP binding
GO:0031175 neuron projection development
GO:0031547 brain-derived neurotrophic factor receptor signaling pathway
GO:0031697 beta-1 adrenergic receptor binding
GO:0032092 positive regulation of protein binding
GO:0032486 Rap protein signal transduction
GO:0032991 protein-containing complex
GO:0035556 intracellular signal transduction
GO:0038180 nerve growth factor signaling pathway
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043547 positive regulation of GTPase activity
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0045202 synapse
GO:0045860 positive regulation of protein kinase activity
GO:0048022 negative regulation of melanin biosynthetic process
GO:0048167 regulation of synaptic plasticity
GO:0048471 perinuclear region of cytoplasm
GO:0050699 WW domain binding
GO:0050774 negative regulation of dendrite morphogenesis
GO:0061028 establishment of endothelial barrier
GO:0070300 phosphatidic acid binding
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071320 cellular response to cAMP
GO:0071321 cellular response to cGMP
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0072659 protein localization to plasma membrane
GO:0090557 establishment of endothelial intestinal barrier
GO:1901888 regulation of cell junction assembly
GO:1990090 cellular response to nerve growth factor stimulus
GO:2000481 positive regulation of cAMP-dependent protein kinase activity
GO:2000670 positive regulation of dendritic cell apoptotic process
GO:2001214 positive regulation of vasculogenesis
GO:2001224 positive regulation of neuron migration

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Late endosome

Domains

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DomainNameCategoryType
IPR000159 Ras-associating (RA) domainDomainDomain
IPR000595 Cyclic nucleotide-binding domainDomainDomain
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminalDomainDomain
IPR001478 PDZ domainDomainDomain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domainDomainDomain
IPR008937 Ras-like guanine nucleotide exchange factorFamilyFamily
IPR014710 RmlC-like jelly roll foldFamilyHomologous superfamily
IPR018490 Cyclic nucleotide-binding-likeFamilyHomologous superfamily
IPR023578 Ras guanine nucleotide exchange factor domain superfamilyFamilyHomologous superfamily
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR030739 Rap guanine nucleotide exchange factor 2FamilyFamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily

Diseases

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