Entity Details

Primary name IRS2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y4H2
EntryNameIRS2_HUMAN
FullNameInsulin receptor substrate 2
TaxID9606
Evidenceevidence at protein level
Length1338
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesIRS2

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002903 negative regulation of B cell apoptotic process
GO:0005158 insulin receptor binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006006 glucose metabolic process
GO:0007165 signal transduction
GO:0007411 axon guidance
GO:0007420 brain development
GO:0008284 positive regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0009749 response to glucose
GO:0010748 negative regulation of long-chain fatty acid import across plasma membrane
GO:0010907 positive regulation of glucose metabolic process
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0019216 regulation of lipid metabolic process
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0019904 protein domain specific binding
GO:0030335 positive regulation of cell migration
GO:0030879 mammary gland development
GO:0030890 positive regulation of B cell proliferation
GO:0032000 positive regulation of fatty acid beta-oxidation
GO:0032024 positive regulation of insulin secretion
GO:0032869 cellular response to insulin stimulus
GO:0032991 protein-containing complex
GO:0033673 negative regulation of kinase activity
GO:0038111 interleukin-7-mediated signaling pathway
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0046326 positive regulation of glucose import
GO:0046579 positive regulation of Ras protein signal transduction
GO:0048015 phosphatidylinositol-mediated signaling
GO:0051897 positive regulation of protein kinase B signaling
GO:0055088 lipid homeostasis
GO:0071333 cellular response to glucose stimulus
GO:0071889 14-3-3 protein binding

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001849 Pleckstrin homology domainDomainDomain
IPR002404 IRS-type PTB domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR039011 Insulin receptor substrateFamilyFamily

Diseases

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Interactions

52 interactions

InteractorPartnerSourcesPublicationsLink
IRS2_HUMANIGF1R_HUMANHPRD, MINT8662806 9852124 details
IRS2_HUMANINSR_HUMANBioGRID, HPRD, MINT8626379 8662806 9195949 details
IRS2_HUMAN1433T_HUMANBioGRID, IntAct15161933 17353931 28514442 details
IRS2_HUMANGRB2_HUMANBioGRID, HPRD, IntAct21706016 22974441 7559579 9852124 details
IRS2_HUMANSIR1_HUMANBioGRID, UniProt17901049 21241768 details
IRS2_HUMANP85A_HUMANBioGRID, HPRD, IntAct, MINT, UniProt11438664 12107746 12506011 15514089 19561084 21241768 23439647 23617393 26496610 8910607 9334184 9852124 details
IRS2_HUMANPCNA_HUMANUniProt26030842 details
IRS2_HUMANPLCG1_HUMANBioGRID, HPRD22974441 9535722 details
IRS2_HUMANTYK2_HUMANBioGRID, HPRD8550573 details
IRS2_HUMANRPTOR_HUMANBioGRID19561084 details
IRS2_HUMANNTRK1_HUMANBioGRID, HPRD11147812 25921289 details
IRS2_HUMANSRPK2_HUMANBioGRID26167880 details
IRS2_HUMANNEDD4_HUMANBioGRID25879670 details
IRS2_HUMAN1433E_HUMANBioGRID, HPRD, MINT17979178 9312143 details
IRS2_HUMAN1433Z_HUMANBioGRID, HPRD, IntAct, MINT15161933 26496610 28514442 9312143 details
IRS2_HUMAN1433S_HUMANBioGRID, MINT15778465 details
IRS2_HUMANP55G_HUMANBioGRID, HPRD, IntAct10417350 28514442 details
IRS2_HUMANSOCS1_HUMANBioGRID, HPRD12228220 27507812 29991678 details
IRS2_HUMANPTN11_HUMANBioGRID, HPRD8910607 details
IRS2_HUMANEPOR_HUMANBioGRID, HPRD9334184 details
IRS2_HUMANBCL2_HUMANBioGRID10679027 details
IRS2_HUMANJAK1_HUMANBioGRID, HPRD7499365 details
IRS2_HUMANNISCH_HUMANBioGRID11912194 details
IRS2_HUMANIRS1_HUMANBioGRID12554758 details
IRS2_HUMANUBF1_HUMANBioGRID, HPRD12554758 details
IRS2_HUMANESR1_HUMANBioGRID12821935 details
IRS2_HUMANGRB10_HUMANBioGRID12783867 27742835 details
IRS2_HUMANPK3CA_HUMANBioGRID, HPRD12933652 25879670 9113989 details
IRS2_HUMANSOCS3_HUMANBioGRID, HPRD15514089 details
IRS2_HUMANDVL2_HUMANBioGRID24616100 details
IRS2_HUMANEPN1_HUMANBioGRID25879670 details
IRS2_HUMANUBP15_HUMANBioGRID28126338 details
IRS2_HUMANUBP7_HUMANBioGRID28126338 details
IRS2_HUMANMTOR_HUMANBioGRID27742835 details
IRS2_HUMANKS6B1_HUMANBioGRID27742835 details
IRS2_HUMANSH2B1_HUMANBioGRID15316008 details
IRS2_HUMANUSP9X_HUMANBioGRID30338032 details
IRS2_HUMANPTPRF_HUMANHPRD15588985 8732688 details
IRS2_HUMANAT2A1_HUMANHPRD9295312 details
IRS2_HUMANB2CL1_HUMANHPRD10679027 details
IRS2_HUMANJAK3_HUMANHPRD7499365 details
IRS2_HUMANSHC1_HUMANHPRD11505033 details
IRS2_HUMANSOCS6_HUMANHPRD12052866 details
IRS2_HUMANJAK2_HUMANHPRD12960006 details
IRS2_HUMANPTN6_HUMANHPRD12198247 details
IRS2_HUMANAT2A2_HUMANHPRD9295312 details
IRS2_HUMANTPOR_HUMANHPRD11054408 details
IRS2_HUMANCRK_HUMANHPRD8621590 details
IRS2_HUMANFES_HUMANHPRD10856136 details
IRS2_HUMANP85B_HUMANHPRD10594015 9651378 details
IRS2_HUMANSOCS7_HUMANHPRD12052866 details
IRS2_HUMANIL4RA_HUMANHPRD8954948 details