Entity Details

Primary name CORIN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y5Q5
EntryNameCORIN_HUMAN
FullNameAtrial natriuretic peptide-converting enzyme
TaxID9606
Evidenceevidence at protein level
Length1042
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesCORIN

GO terms

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GOName
GO:0003050 regulation of systemic arterial blood pressure by atrial natriuretic peptide
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007565 female pregnancy
GO:0008217 regulation of blood pressure
GO:0009986 cell surface
GO:0015629 actin cytoskeleton
GO:0016021 integral component of membrane
GO:0016486 peptide hormone processing
GO:0016604 nuclear body
GO:0035813 regulation of renal sodium excretion
GO:1903779 regulation of cardiac conduction

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeatRepeatRepeat
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR017052 Atrial natriuretic peptide-converting enzyme corinFamilyFamily
IPR017448 SRCR-like domainDomainDomain
IPR020067 Frizzled domainDomainDomain
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved siteSiteConserved site
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR036055 LDL receptor-like superfamilyFamilyHomologous superfamily
IPR036772 SRCR-like domain superfamilyFamilyHomologous superfamily
IPR036790 Frizzled cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR041762 Corin, cysteine-rich domain 1DomainDomain
IPR041763 Corin, cysteine-rich domain 2DomainDomain
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
CORIN_HUMANAQP6_HUMANBioGRID, IntAct32296183 details
CORIN_HUMANCLD5_HUMANBioGRID, IntAct32296183 details
CORIN_HUMANEMP1_HUMANBioGRID, IntAct32296183 details
CORIN_HUMANGPX8_HUMANBioGRID, IntAct32296183 details