Entity Details

Primary name IRAK3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y616
EntryNameIRAK3_HUMAN
FullNameInterleukin-1 receptor-associated kinase 3
TaxID9606
Evidenceevidence at protein level
Length596
SequenceStatuscomplete
DateCreated2004-11-09
DateModified2021-06-02

Ontological Relatives

GenesIRAK3

GO terms

Show/Hide Table
GOName
GO:0000287 magnesium ion binding
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0009615 response to virus
GO:0010933 positive regulation of macrophage tolerance induction
GO:0010936 negative regulation of macrophage cytokine production
GO:0019221 cytokine-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032494 response to peptidoglycan
GO:0032496 response to lipopolysaccharide
GO:0032695 negative regulation of interleukin-12 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0035556 intracellular signal transduction
GO:0042177 negative regulation of protein catabolic process
GO:0042803 protein homodimerization activity
GO:0043242 negative regulation of protein-containing complex disassembly
GO:0043244 regulation of protein-containing complex disassembly
GO:0043330 response to exogenous dsRNA
GO:0043407 negative regulation of MAP kinase activity
GO:0045824 negative regulation of innate immune response
GO:0046777 protein autophosphorylation
GO:0046982 protein heterodimerization activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070555 response to interleukin-1
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000488 Death domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR033610 Interleukin-1 receptor-associated kinase 3FamilyFamily
IPR042698 Interleukin-1 receptor-associated kinase 3, pseudokinase domainDomainDomain
IPR042747 IRAK3, death domainDomainDomain

Diseases

Show/Hide Table
Disease IDSourceNameDescription
611064 OMIMAsthma-related traits 5 (ASRT5)Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Drugs

Show/Hide Table
DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule